311 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28658574	124	3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.	Universit£ degli Studi di Firenze
28272885	126	Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.	Universit£ degli Studi di Firenze
28256371	83	Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.	University of Wollongong
28161252	64	Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.	King Saud University
25432060	92	Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.	Atat£rk University
28075587	102	Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.	University of Florence
27823879	88	New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.	Maastricht University Medical Centre
1635066	17	Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.	Istituto Chimico Internazionale Dr. G. Rende
3735316	8	N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.	TBA
28065499	84	Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.	Kurukshetra University
28024887	52	5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.	Riga Technical University
27939347	52	Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.	Universit£ degli Studi di Firenze
27933963	60	Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.	Universit£ degli Studi di Firenze
27144971	60	PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.	Temple University School of Pharmacy
27290692	18	N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.	Universit£ degli Studi di Firenze
27172398	20	An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.	Griffith University
27316543	24	Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.	Universit£ degli Studi di Firenze
27234893	36	Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.	Cairo University
27166574	52	Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII.	Kurukshetra University
27137360	100	Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII.	Kurukshetra University
26805033	426	Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.	Uppsala University
26875933	72	Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.	DAIS
26840366	72	Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.	Egyptian Russian University
26741028	100	4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.	Universit£ de Reims Champagne-Ardenne
26810836	28	Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.	University of Florida College of Medicine
26810710	116	A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.	University of Chieti-Pescara
26688270	104	Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.	Universit£ degli Studi di Firenze
26803577	92	Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.	Harran University
26520662	45	Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.	Balikesir University
26497049	110	Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.	Sapienza University of Rome
26498394	105	Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.	Universit£ degli Studi di Firenze
26408817	69	Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.	Egyptian Russian University
26432607	60	Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII.	Universit£ degli Studi di Firenze
26422787	68	Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.	Dumlupinar University
26347950	32	Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.	Griffith University
26319622	12	Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.	Universit£ degli Studi di Firenze
26276436	45	Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.	Universit£ degli Studi di Messina
26233435	76	Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.	University of Cagliari
26264840	104	Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.	University of Chieti-Pescara
26160114	101	Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms.	Saint Petersburg State University
26191373	52	Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.	Institute of Biomolecules Max Mousseron (IBMM)
26233796	68	Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.	University of Cagliari
26203869	18	Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.	University of Florida
26105196	52	Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.	Kurukshetra University
26073006	56	New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.	University of Cagliari
26048024	84	Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.	Jazan University
26088336	96	5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.	University of Belgrade
25921266	48	New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.	Siedlce University of Natural Sciences and Humanities
26007302	56	New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.	University of Chieti-Pescara
25875209	60	6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.	Latvian Institute of Organic Synthesis
25913118	95	Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII.	Harran University
25912674	52	Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.	Cairo University
25553540	6	1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.	University of Mississippi
25846066	88	Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.	Universit£ degli Studi di Firenze
25766630	100	A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.	Universit£ degli Studi di Firenze
25757603	79	New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity.	Siedlce University of Natural Sciences and Humanities
25753329	56	Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.	Latvian Institute of Organic Synthesis
25147616	92	Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.	Universit£ di Sassari
25050167	40	Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.	Bharati Vidyapeeth's College of Pharmacy
25027802	56	Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.	Sapienza University of Rome
25022971	124	Furazan and furoxan sulfonamides are stronga-carbonic anhydrase inhibitors and potential antiglaucoma agents.	Universit£ degli Studi di Torino
25019479	96	Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.	Sapienza University of Rome
24948563	44	Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.	University of Perugia
25468040	77	Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.	TBA
25456084	100	4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.	Kurukshetra University
25442309	120	Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.	King Saud University
25438758	44	Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.	Ecole Nationale Sup£rieure de Chimie de Montpellier
25358084	143	Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.	Vilnius University
25358036	64	A class of 4-sulfamoylphenyl-¿-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.	Universit£ degli Studi di Firenze
25310626	80	Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.	Universit£ degli Studi di Firenze
25267005	70	Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.	Universit£ degli Studi di Firenze
25255434	84	Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.	King Saud University
25254302	44	Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.	Griffith University
25245672	5	Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis,ß-glucuronidase inhibition activity, crystal structure, and POM analyses.	King Saud University
25156300	48	Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.	Universidad Nacional de La Plata
24878360	76	Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.	King Saud University
24871996	124	Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.	Medical University of Gdansk
24813742	98	Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.	Universit£ degli Studi
24713308	48	Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.	Siedlce University of Natural Sciences and Humanities
24589511	60	Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.	University of Cagliari
24689792	54	Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.	Griffith University
24650641	110	Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.	Universit£ degli Studi 'Aldo Moro' di Bari
23664215	45	Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.	East China University of Science and Technology
23647428	84	Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.	Universit£ degli Studi di Firenze
23490152	15	Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.	University of Florida
23429054	48	Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.	East China University of Science and Technology
23352754	28	o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.	Istanbul University
23290254	92	Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.	Salman Bin Abdulaziz University
23206986	259	QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII.	Romanian Academy
23199483	25	Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.	Ecole Nationale Sup£rieure de Chimie de Montpellier
23168081	72	New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.	University of Lille
23098607	2	Carbonic anhydrase IX as a target for metastatic disease.	University of Manchester
23018095	36	Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.	Universit£ degli Studi di Pisa
23010455	108	Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.	Universidad Nacional de La Plata
22974493	13	Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.	Agri Ibrahim Cecen University
22892213	168	Natural product coumarins that inhibit human carbonic anhydrases.	Griffith University
22705188	73	Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.	Superacide et Chimie des syst£mes£ team-Universit£ de Poitiers
22668600	200	Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.	Universit£ degli Studi di Firenze
23265898	20	Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.	Universit£ degli Studi di Firenze
23241068	84	Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.	Latvian Association of Human Genetics
22910138	96	Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.	TBA
23067387	105	Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibita- andß-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.	Universit£ di Pisa
22894736	99	Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment.	The Hebrew University of Jerusalem
22775345	74	Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.	Istituto di Biostrutture e Bioimmagini-CNR
22621623	44	Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.	University of Manchester
22901388	76	Inhibition ofa-class cytosolic human carbonic anhydrases I, II, IX and XII, andß-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.	Universit£ di Sassari
22721713	200	Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.	Ecole Nationale Sup£rieure de Chimie de Montpellier
22443141	115	Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.	Universit£ di Messina
22276570	112	Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.	Universit£ degli Studi di Firenze
22487176	109	Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.	Universit£ degli Studi di Cagliari
21211980	47	Characterization and anions inhibition studies of ana-carbonic anhydrase from the teleost fish Dicentrarchus labrax.	Ondokuz Mayis University
20580561	33	Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.	Instituto Superior T£cnico
20674354	79	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.	Universit£ degli Studi di Firenze
20605094	91	Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.	University of Florida
20598552	24	Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.	University of Florida
20478708	28	New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.	LNEG
20472429	80	Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.	Istituto di Biostrutture e Bioimmagini-CNR
20201556	174	Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.	Griffith University
20185318	132	Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.	Universit£ degli Studi di Firenze
19911821	273	Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.	Universita degli Studi di Firenze
20028100	78	The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.	Universit£ degli Studi di Firenze
19827837	52	S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.	Griffith University
19398204	44	Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.	Universit£ di Messina
19286378	75	Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.	Griffith University
19186056	60	A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.	Universit£ degli Studi di Firenze
18513964	45	Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.	Universit£ degli Studi di Firenze
18359629	84	Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.	Istituto di Biostrutture e Bioimmagini-CNR
18042384	60	Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.	Ecole Nationale Sup£rieure de Chimie de Montpellier
18307288	70	Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.	Griffith University
17475500	130	Carbonic anhydrases as targets for medicinal chemistry.	Universit£ degli Studi di Firenze
17681760	21	Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.	Griffith University
17376683	63	Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.	Ecole Nationale Sup£rieure de Chimie de Montpellier
17314045	11	Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.	Universit£ degli Studi di Firenze
17276072	95	Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.	Universit£ di Pisa
17228881	141	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.	Kochi Medical School
16290146	30	Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II"selective" inhibitor celecoxib.	Istituto di Biostrutture e Bioimmagini-CNR
16203142	55	Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.	Universit£ degli Studi di Firenze
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
15664816	65	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.	Universit£ degli Studi di Firenze
15664814	55	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.	Universit£ degli Studi di Firenze
15603956	63	Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.	Harran University
16039848	93	Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.	Kochi Medical School
15905091	134	Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.	Universit£ degli Studi di Firenze
15546717	130	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.	Pennsylvania State University
15501039	51	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.	Universit£ degli Studi di Firenze
15501038	68	Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.	Universit£ degli Studi di Firenze
15454239	74	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.	Universit£ degli Studi di Firenze
12747791	91	Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.	University of Montpellier
15012984	192	Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.	Slovak Academy of Sciences
15081039	68	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.	Universit£ degli Studi di Firenze
15203157	68	Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.	University of Tampere
15149691	32	Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.	Laxmi Fumigation and Pest Control (P)
14684333	9	Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.	Universit£ degli Studi di Firenze
14684331	24	Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.	Universit£ degli Studi di Firenze
12643899	127	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.	Universit£ degli Studi di Firenze
22377674	80	Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.	Universit£ degli Studi di Firenze
22370338	183	Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.	Griffith University
22365761	144	New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.	Universit£ degli Studi di Firenze
22077347	44	Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.	Ecole Nationale Sup£rieure de Chimie de Montpellier
22137345	36	5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.	Universit£ degli Studi di Firenze
22041171	44	Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.	Universit£ di Messina
21852133	68	Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.	University of Alberta
21851094	92	Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.	Griffith University
21821413	65	Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against humana- and bacterial/fungalß-carbonic anhydrases.	Ecole Nationale Sup£rieure de Chimie de Montpellier
21820216	75	Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.	Medical University of Gdansk
21515057	153	Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.	Universit£ degli Studi di Firenze
21723123	48	N-ß-glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.	Universidad Nacional de La Plata
21470859	52	Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.	Ecole Nationale Sup£rieure de Chimie de Montpellier
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21282059	48	Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.	University of Calgary
21067924	88	7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.	Università degli Studi di Firenze
20880712	69	Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.	University of Lille
20554082	76	Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.	Medical University of Gdansk
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19615903	6	In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives.	Institute of Pharmaceutical Sciences
19527930	53	The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.	University of Tampere and Tampere University Hospital
19097911	41	Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.	University of Namur
19053764	101	Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.	Instituto Superior Técnico
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18295485	75	Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.	Universita degli Studi di Firenze
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16165351	45	Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.	Università degli Studi di Firenze
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15908204	116	Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.	Ospedale San Lazzaro
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15837325	69	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.	Ospedale San Lazzaro
15837323	66	Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.	University of Bucharest
15780637	3	Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.	University of Naples 'Federico II'
15780631	55	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.	Università degli Studi di Firenze
15745821	21	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.	University of Montpellier
15664815	45	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.	Università degli Studi di Firenze
15501037	27	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.	Università degli Studi di Milano
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26796953	60	Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.	Universit£ di Pisa
26795114	72	Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.	National University of La Plata
26682703	30	Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.	Universit£ degli Studi di Firenze
24589484	92	4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.	Kurukshetra University
24560739	124	Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.	Sapienza University of Rome
24518190	88	6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.	Latvian Institute of Organic Synthesis
24560737	88	Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.	Kurukshetra University
24507918	68	Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.	Shri G.S. Institute of Technology and Science
24513186	52	Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.	Latvian Institute of Organic Synthesis
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24300919	55	Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.	Universit£ degli Studi di Firenze
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24189056	64	Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.	Sapienza University of Rome
24128000	60	Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.	Ecole Nationale Sup£rieure de Chimie de Montpellier
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24095761	72	Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.	Medical University of Gdansk
23993330	10	Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.	University of Florida
23965175	105	Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.	Birla Institute of Technology
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23842519	116	Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.	Bezmialem Vakif University
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23769167	85	7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.	Universit£ degli Studi di Firenze
23706268	4	Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.	University of W£rzburg
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30344915	45	Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.	University of Cagliari
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30258546	56	Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.	University of Florence
28947945	72	Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.	University of Florence
28947941	44	Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.	University of Sassari
28802125	92	Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.	Kafrelsheikh University
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29909339	84	Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.	Kurukshetra University
29852328	22	Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.	Jamia Millia Islamia
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29684705	72	Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.	Egyptian Russian University
29635168	140	2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.	University of Florence
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30034596	8	Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.	University of Florida
29912561	40	4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.	Universit£ di Pisa
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29851481	122	Discovery of ?-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.	University of Florence
29197732	112	Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.	University of Messina
29146134	64	Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies.	Medical University of Gdansk
29259736	70	Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.	University of Florence
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28887000	72	Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.	National Institute of Pharmaceutical Education and Research (NIPER)
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28302505	120	Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.	Universit£ degli Studi di Firenze
29266943	8	"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.	University of Florida
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28453941	114	Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.	Universit£ degli Studi di Messina
28259376	11	Green synthesis, inhibition studies of yeast a-glucosidase and molecular docking of pyrazolylpyridazine amines.	University of the Punjab
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