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220 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337317 30 Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI Wayne State University
27541357 58 Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.EBI National University of Singapore
28057407 76 Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI Georgia Institute of Technology
27769671 66 Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.EBI Tsinghua University
27344487 16 2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.EBI Taipei Medical University
27717544 75 Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.EBI Integral BioSciences Pvt. Ltd
27650925 15 Synthesis of a selective HDAC6 inhibitor active in neuroblasts.EBI University of Geneva
27606546 218 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI University of Navarra
27377864 55 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI Broad Institute of MIT and Harvard
27186676 186 Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI West China Hospital of Sichuan University
27142751 22 Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.EBI China Pharmaceutical University
26937828 137 Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.EBI Martin-Luther University of Halle-Wittenberg
26996372 10 Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.EBI Sungkyunkwan University
26890116 30 Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI University of Milan
27060764 30 Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI Sungkyunkwan University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26890114 56 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.EBI Shanghai Institute of Materia Medica
26681404 40 Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.EBI Washington University School of Medicine
26653328 67 Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.EBI Albert-Ludwigs-University Freiburg
26705137 31 Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.EBI Universidade Federal de Alfenas
26814680 71 Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI Shenyang Pharmaceutical University
26804233 38 Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.EBI Massachusetts General Hospital
26706171 138 Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI Shenyang Pharmaceutical University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26741358 56 Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.EBI China Pharmaceutical University
26629860 58 Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.EBI European Institute of Oncology
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26639764 17 Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.EBI Wroclaw University of Technology
26475519 40 Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.EBI China Pharmaceutical University
26241876 1 Triazine as a promising scaffold for its versatile biological behavior.EBI Thapar University
26481659 18 New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.EBI Ronzoni Institute for Chemical and Biochem. Research
26376355 14 Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.EBI University of Milan
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26086931 38 Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.EBI Shandong University
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26287310 87 Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI University College London
26211462 71 Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
22344701 30 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI Novartis Institutes for BioMedical Research
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
25261927 80 Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
26054247 48 Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.EBI Colorado State University
26100440 6 Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.EBI Shandong University
25993269 140 Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.EBI Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
26035239 1 Natural Product Primary Sulfonamides and Primary Sulfamates.EBI Griffith University
25974739 17 Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.EBI University of California
25815139 18 Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.EBI Fujian University of Traditional Chinese Medicine
25971769 25 Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.EBI MethylGene Inc.
25906087 14 Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI Shandong University
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25811792 32 Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.EBI Yonsei University
25899338 37 Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.EBI Georgia Institute of Technology
25800646 40 Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.EBI Central South University
25734520 104 Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.EBI Roche Innovation Center Shanghai
25113875 14 Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.EBI Taipei Medical University
25042254 7 Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI H�pital Kirchberg
24999749 1 A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.EBI University of Oklahoma
24972008 36 1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.EBI Sapienza University of Rome
24864038 112 Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI Nippon Pharmaceutical Chemicals Co., Ltd
25563890 49 Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
25462271 33 Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI Shandong University
25455492 22 Aurones as histone deacetylase inhibitors: identification of key features.EBI University of Geneva
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25380299 61 Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI Technical University of Denmark
25240614 6 The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.EBI Georgia Institute of Technology
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25233084 247 ST7612AA1, a thioacetate-(-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite SpA
25221651 12 Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.EBI University of Bologna
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
25176189 7 Design, synthesis and biological evaluation of-boswellic acid based HDAC inhibitors as inducers of cancer cell death.EBI CSIR-Indian Institute of Integrative Medicine
24944733 101 Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.EBI Chinese National Center for Drug Screening
24900884 14 Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.EBI Nagoya University
24766560 16 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI Taipei Medical University
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
24694055 35 Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI Shandong University
23570542 48 Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.EBI National Taiwan University
23547652 27 3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.EBI Georgia Institute of Technology
23368884 80 Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI Broad Institute of MIT and Harvard
23252603 35 Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.EBI Heinrich Heine Universit£t
23089527 6 The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.EBI Wayne State University
23116147 30 Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.EBI Kyoto Prefectural University of Medicine
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
24900543 27 Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.EBI TBA
23021104 32 Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.EBI Graduate School of Life Science and Systems Engineering
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
24900500 21 Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.EBI TBA
22738629 47 CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.EBI Chinese Academy of Sciences
22439863 21 Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.EBI Taipei Medical University
22280363 104 Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.EBI Imperial College London
22541394 30 Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI Guru Ghasidas University
22260166 17 Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.EBI Georgia Institute of Technology
22165909 48 Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.EBI University of Illinois at Chicago
21984958 83 Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of F508-CFTR.EBI TBA
21874153 54 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI Broad Institute of Harvard and MIT
16408003 7 Diversity-oriented synthesis: exploring the intersections between chemistry and biology.EBI Memorial Sloan-Kettering Cancer Center
20472442 25 On the inhibition of histone deacetylase 8.EBI University of Notre Dame
20452225 49 Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.EBI McGill University
20392637 159 Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.EBI Takeda San Diego
19705846 100 Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.EBI The Scripps Research Institute
19854643 8 Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide.EBI School of Chemistry and Biochemistry
18809328 64 Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
18430569 26 Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.EBI The Broad Institute of Harvard and MIT
18397826 18 Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.EBI Waseda University
18054239 54 Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).EBI University of Freiburg
18182289 127 Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18247554 134 Histone deacetylase inhibitors: from bench to clinic.EBI Menarini Ricerche
16987657 45 A series of novel, potent, and selective histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
15454224 15 Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.EBI CREST Research Project
14613312 106 Histone deacetylase inhibitors.EBI Aton Pharma, Inc
14584932 23 Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.EBI Universit£ degli Studi di Roma"La Sapienza"
11206439 51 Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.EBI Merck Research Laboratories
11206438 48 Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.EBI Merck Research Laboratories
21417419 5 Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.EBI DAC SRL
22182579 110 Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.EBI University of Applied Sciences
21721525 8 In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).EBI Harvard Medical School
21548582 57 Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI University of Illinois at Chicago
21889343 6 The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.EBI Wayne State University
21793558 39 Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.EBI University of Wisconsin-Milwaukee
21714538 2 Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities.EBI Shandong University
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21712146 20 Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.EBI Taipei Medical University
21723733 12 Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.EBI Novartis Institutes for Biomedical Research
21745740 10 Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.EBI East China Normal University
21696956 243 A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI Broad Institute of Harvard and MIT
21080647 27 Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.EBI Chroma Therapeutics Ltd.
21476600 43 Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.EBI Shandong University
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
21256006 11 Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI Yonsei University
21073160 143 Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and ActivityEBI TBA
21080629 153 Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.EBI University of Regensburg
20947351 24 Inhibitors selective for HDAC6 in enzymes and cells.EBI The University of Queensland
20883026 3 An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist.EBI McGill University
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20637529 15 Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI Università degli Studi di Milano
20669972 18 Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.EBI Georgia Institute of Technology
20223566 23 Inside HDAC with HDAC inhibitors.EBI Universit£ de Poitiers
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20381359 17 Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI Universit£ degli Studi di Salerno
20205394 44 Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI Novartis Institutes for Biomedical Research
20055418 78 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI University of Illinois at Chicago
20045316 18 Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.EBI Graduate School of Life Science and Systems Engineering
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19699639 58 Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.EBI MethylGene Inc.
19888759 42 Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.EBI Istituto Di Ricerche Di Biologia Molecolare
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19441846 35 Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.EBI IRBM/Merck Research Laboratories
19419863 58 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI University of Illinois at Chicago
19419205 28 Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.EBI Nagoya City University
19410459 33 Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI IRBM/Merck Research Laboratories
19301902 104 Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.EBI University of Regensburg
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19272776 63 Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.EBI MethylGene Inc.
19268585 30 Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
19114304 44 SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).EBI MethylGene Inc.
19111466 42 Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.EBI MethylGene Inc
19084395 45 Sulfamides as novel histone deacetylase inhibitors.EBI MethylGene Inc.
18952417 50 Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.EBI IRBM-Merck Research Laboratories Rome
18951790 109 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18930398 117 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.EBI IRBM-Merck Research Laboratories Rome
18672316 41 Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI Institute of Organic Synthesis
18642892 76 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI University of Illinois at Chicago
18558669 119 Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.EBI Nycomed GmbH
18060775 67 Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI Merck Research Laboratories
17900911 21 Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.EBI Graduate School of Life Science and Systems Engineering
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17588744 18 Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.EBI The University of Tokyo
17555962 26 Design of novel histone deacetylase inhibitors.EBI Merck Research Laboratories
17539623 65 Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.EBI University of Illinois at Chicago
17346959 14 Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.EBI Ithaca College
16884291 12 Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.EBI Nagoya City University
16137884 6 Design and synthesis of phthalimide-type histone deacetylase inhibitors.EBI The University of Tokyo Yayoi
14698179 58 Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.EBI The Scripps Research Institute
28196613 34 Potent and Selective EphA4 Agonists for the Treatment of ALS.BDB Sanford-Burnham-Prebys Medical Discovery Institute
27416889 35 Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.BDB Shandong University
1586393 43 Localization and function of the D3 dopamine receptor.BDB U. 109
1554381 19 Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB National Institutes of Diabetes and Digestive and Kidney Diseases
1501121 12 Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.BDB Sanofi Recherche
282646 50 Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.BDB TBA
37098 14 Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.BDB TBA
18291323 20 Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.BDB University of Amsterdam
25019596 24 Quinolone-based HDAC inhibitors.BDB Orchid Chemicals & Pharmaceuticals Limited
11472208 24 Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.BDB Universita degli Studi di Roma La Sapienza