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91 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
15050627 49 Hydroxytriamides as potent gamma-secretase inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15177469 24 Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.EBI Tokyo University of Science
27038496 2 Part 3: Notch-sparing┐-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.EBI Harvard Medical School
27013392 10 Part 1: Notch-sparing┐-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.EBI Harvard Medical School
26898338 4 Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based┐-secretase modulators.EBI Bristol-Myers Squibb Co.
26848108 36 Design and optimization of tricyclic gamma-secretase modulators.EBI Bristol-Myers Squibb Research and Development
26496070 96 Discovery of a Novel, Potent Spirocyclic Series of┐-Secretase Inhibitors.EBI Merck Research Laboratories
26288679 12 Fused Morphlinopyrimidines and Methods of Use Thereof.EBI Temple University School of Pharmacy
26142947 77 Potent benzoazepinone┐-secretase modulators with improved bioavailability.EBI Merck Research Laboratories
25582600 22 Discovery of indole-derived pyridopyrazine-1,6-dione┐-secretase modulators that target presenilin.EBI Pfizer Inc
26005540 14 Design of Pyridopyrazine-1,6-dione┐-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.EBI Pfizer Inc
25575659 124 SAR-studies of┐-secretase modulators with PPAR┐-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI Goethe-University Frankfurt
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
25454273 52 Anilinotriazoles as potent gamma secretase modulators.EBI Janssen Pharmaceutica NV
23707256 62 Membrane anchoring┐-secretase modulators with terpene-derived moieties.EBI Technische Universit£t Darmstadt
24900404 27 Discovery of SCH 900229, a Potent Presenilin 1 Selective ┐-Secretase Inhibitor for the Treatment of Alzheimer's Disease.EBI TBA
15588083 66 Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.EBI Harvard Medical School
15050631 21 Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.EBI Harvard Medical School
17573346 2 Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.EBI Emmy Noether Research Group
16766183 24 Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.EBI University of Tokyo
16682202 14 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.EBI Merck Sharp and Dohme Research Laboratories
16682195 37 Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.EBI University of Tokyo
16617016 13 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.EBI Neuroscience Research Centre
16054361 17 Cyclic sulfamide gamma-secretase inhibitors.EBI Merck Sharp and Dohme Research Laboratories
15863342 21 Aryl sulfones: a new class of gamma-secretase inhibitors.EBI Merck Sharp & Dohme Research Laboratories
15603957 62 A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.EBI Merck Sharp & Dohme Research Laboratories
15267231 17 Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.EBI Harvard Medical School
14592525 18 High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.EBI Merck Sharp & Dohme Research Laboratories
12643944 26 Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
27020305 5 Part 2. Notch-sparing ?-secretase inhibitors: The study of novel ?-amino naphthyl alcohols.EBI Harvard Medical School
26212776 69 Discovery of novel triazolobenzazepinones as ?-secretase modulators with central A?42 lowering in rodents and rhesus monkeys.EBI Merck Research Laboratories Boston
24914408 6 Development of CBAP-BPyne, a probe for ?-secretase and presenilinase.EBI Memorial Sloan-Kettering Cancer Center
24900755 3 Gamma secretase modulators.EBI Montclair State University
23312944 38 Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors.EBI Elan Pharmaceuticals
23342950 35 Effect of helical conformation and side chain structure on ?-secretase inhibition by ?-peptide foldamers: insight into substrate recognition.EBI Nagoya City University
23265902 48 A-ring modification of SCH 900229 and related chromene sulfone ?-secretase inhibitors.EBI Merck Research Laboratories
23265892 54 Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors.EBI Merck Research Laboratories
24900409 43 Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer's Disease.EBI Merck Research Laboratory
23046960 2 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors.EBI Bristol-Myers Squibb R&D
24900406 2 Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside.EBI Satori Pharmaceuticals, Inc.
22420884 21 Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active ?-secretase inhibitor.EBI Pfizer Inc.
22483609 52 Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors.EBI Merck Research Laboratories
22418280 5 Development of clickable active site-directed photoaffinity probes for ?-secretase.EBI Memorial Sloan-Kettering Cancer Center
21995460 23 Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as ?-secretase inhibitors.EBI Pfizer Inc.
21885276 46 Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent ?-secretase inhibitors.EBI Elan Pharmaceuticals
21763147 64 NSAID-derived ?-secretase modulation requires an acidic moiety on the carbazole scaffold.EBI Technische Universit£t Darmstadt
21742495 40 Pyridine-derived ?-secretase modulators.EBI GlaxoSmithKline Pharmaceuticals
21636276 40 Pyridazine-derived ?-secretase modulators.EBI GlaxoSmithKline Pharmaceuticals
21269827 29 Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as ?-secretase inhibitors: discovery of PF-3084014.EBI Pfizer Inc.
21269825 50 Diamide amino-imidazoles: a novel series of ?-secretase inhibitors for the treatment of Alzheimer's disease.EBI Pfizer Inc.
21195610 35 Discovery of fused 5,6-bicyclic heterocycles as ?-secretase modulators.EBI Merck Research Laboratories
20724152 40 Iminoheterocycles as gamma-secretase modulators.EBI Merck Research Laboratories
20650635 12 Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.EBI Okayama University Graduate School of Medicine
20529683 45 Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).EBI Elan Pharmaceuticals
20207146 7 Purine derivatives as potent gamma-secretase modulators.EBI Merck Research Laboratories
20207136 71 Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.EBI Elan Pharmaceuticals
19879754 57 NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.EBI Technische Universit£t Darmstadt
20056541 83 Piperidine-derived gamma-secretase modulators.EBI GlaxoSmithKline
20022243 8 Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.EBI Merck Research Laboratories
20005099 22 Fluorinated piperidine acetic acids as gamma-secretase modulators.EBI Merck Research Laboratories
19879755 33 N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.EBI Elan Pharmaceuticals
19660943 48 Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.EBI Elan Pharmaceuticals
19443228 1 Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.EBI Wyeth Research
19432431 19 Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.EBI Merck Sharp & Dohme Research Laboratories
19097779 2 Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.EBI Memorial Sloan-Kettering Cancer Center
17932033 14 Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.EBI Bristol-Myers Squibb Research and Development
17983746 31 Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.EBI F. Hoffmann-La Roche Ltd
18061448 16 Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.EBI Merck Sharp and Dohme Research Laboratories
18023581 39 Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.EBI Bristol-Myers Squibb
17869509 57 Amino-caprolactam derivatives as gamma-secretase inhibitors.EBI Bristol-Myers Squibb Research and Development
17723298 28 Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.EBI Darmstadt University of Technology
17502137 29 Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17079141 54 Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.EBI Schering-Plough Research Institute
17046254 24 Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors.EBI Schering-Plough Research Institute
17035010 46 N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.EBI Darmstadt University of Technology
17869099 37 Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.EBI F. Hoffmann-La Roche Ltd
17764937 106 Thiazole-diamides as potent gamma-secretase inhibitors.EBI Pfizer Inc.
17606371 47 N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.EBI Bristol-Myers Squibb Research and Development
17502143 49 Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors.EBI Bristol-Myers Squibb Co.
17055268 33 2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.EBI Schering-Plough Research Institute
29670685 10 Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer's Disease.EBI Temple University School of Pharmacy
29541352 6 Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer's Disease.EBI Temple University School of Pharmacy
29477076 24 Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.EBI Indian Institute of Technology (Banaras Hindu University)
29249626 12 Discovery of novel scaffolds for ?-secretase modulators without an arylimidazole moiety.EBI Astellas Pharma Inc.
29057041 17 Discovery of a Tetrahydrobenzisoxazole Series of ?-Secretase Modulators.EBI Merck Research Laboratories
29735425 45 Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.EBI Boehringer Ingelheim Pharma GmbH & Co. KG
18178084 24 Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.BDB Bristol-Myers Squibb Co.
16275079 29 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.BDB Merck Research Laboratories
18556202 37 Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.BDB Wyeth Research
19012391 8 Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.BDB Wyeth Research