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155 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28076827 27 New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.EBI Universit£ degli Studi di Bari"Aldo Moro"
27591006 24 Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.EBI The University of Tokyo
27660684 18 PPAR Agonists, Compounds, Pharmaceutical Compositions, and Methods of Use Thereof.EBI Temple University
27326332 66 Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI Bristol-Myers Squibb Co.
27450788 3 Syringaresinol induces mitochondrial biogenesis through activation of PPAR▀ pathway in skeletal muscle cells.EBI Korea University
26988304 12 Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor▀/d agonists with neuroprotective activity.EBI Texas Tech University Health Sciences Center
26819660 82 SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR┐ Inhibitor.EBI Central Pharmaceutical Research Institute
26731300 3 Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.EBI Max Planck Institute for Molecular Genetics
26595749 77 N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor┐ Modulators.EBI Goethe-University Frankfurt
26707398 2 Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum.EBI Northwest A & F University
26707845 16 Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPAR▀/d antagonists: Effects on the affinity and selectivity towards PPAR▀/d.EBI University of Oslo
25982078 13 Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor┐/d agonists.EBI Sookmyung Women's University
25583100 107 Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.EBI Goethe-University Frankfurt
25768705 4 Synthesis, biological evaluation and molecular modeling studies of the PPAR▀/d antagonist CC618.EBI University of Oslo
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
25491112 19 Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists.EBI National Institute of Pharmaceutical Education and Research (NIPER)
25462281 17 Structural development studies of PPARs ligands based on tyrosine scaffold.EBI Universit£"G. d'Annunzio"
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI Phenex Pharmaceuticals AG
25255039 45 Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.EBI Goethe-University Frankfurt
24745969 36 Identification of the first potent, selective and bioavailable PPARa antagonist.EBI Inception Sciences
9836620 94 N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.EBI Glaxo Wellcome Research and Development
23286787 18 Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.EBI Helmholtz Centre for Infection Research
23265844 18 The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.EBI The University of Sydney
23265881 49 Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.EBI Pfizer Inc
24900572 54 Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.EBI Pfizer Inc
21414782 178 Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy.EBI GlaxoSmithKline
20128594 51 Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.EBI GlaxoSmithKline
22081932 32 Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.EBI Istituto Tumori"Giovanni Paolo II"
23130964 25 Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.EBI ZAFES/LiFF/OSF Goethe-University Frankfurt
23031596 21 Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.EBI Chungnam National University
23022278 14 Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.EBI Okayama University
22582973 21 Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.EBI Trinity College
22564380 624 Activity landscape modeling of PPAR ligands with dual-activity difference maps.EBI Universidad Nacional Aut£noma de M£xico
22534184 87 Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo.EBI Seoul National University
22579420 45 Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.EBI Korea Institute of Science and Technology
22503460 37 Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists.EBI Takeda Pharmaceutical Co., Ltd
22381047 30 Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.EBI Chungnam National University
21218783 117 Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
21128600 16 Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship.EBI Okayama University
18155554 87 Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
17964792 31 Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI Nippon Shinyaku Co. Ltd
18162399 37 SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.EBI University of Tokyo
18280733 27 Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI Nippon Shinyaku Co. Ltd
18029176 66 Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.EBI Johnson & Johnson
17560785 12 Design of a partial PPARdelta agonist.EBI Novo Nordisk A/S
17005393 35 Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.EBI Eli Lilly and Company
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
16134928 34 Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI The Scripps Research Institute
22185225 2 Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.EBI The University of Tokyo
22070604 150 Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators.EBI Merck Research Laboratories
22209730 73 A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides.EBI Takeda Pharmaceutical Co., Ltd
22133631 76 Discovery of cyclic amine-substituted benzoic acids as PPARa agonists.EBI Kyorin Pharmaceutical Co., Ltd
22051054 18 Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.EBI University of Oslo
21514830 39 Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity.EBI The University of Tokyo
21344906 54 Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.EBI The University of Tokyo
21530275 42 Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists.EBI Okayama University
21515063 60 Biological evaluation of novel benzisoxazole derivatives as PPARd agonists.EBI Nippon Chemiphar Co., Ltd
21094606 24 Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists.EBI AstraZeneca R&D Charnwood
21112784 15 Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation.EBI Nippon Chemiphar Co., Ltd
21215640 21 Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.EBI Zydus Research Centre
21074432 25 Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo.EBI Seoul National University
20843696 12 Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR)d-selective partial agonists by disruption of molecular planarity/symmetry.EBI The University of Tokyo
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
20452212 26 Glycine amides as PPARalpha agonists.EBI Bayer-Schering Pharma
20218621 131 Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).EBI Bristol-Myers Squibb Co.
19928766 425 Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.EBI The Genomics Institute of the Novartis Research Foundation
19853439 21 Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.EBI The University of Tokyo
20079636 78 Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.EBI GlaxoSmithKline
19556125 42 Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.EBI Goethe-University Frankfurt
19349176 137 Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.EBI F. Hoffmann-La Roche Inc
19301897 63 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.EBI National Health Research Institutes
19275963 26 Selective, potent PPARgamma agonists with cyclopentenone core structure.EBI Universidade de Vigo
18947994 102 The discovery of equipotent PPARalpha/gamma dual activators.EBI GlaxoSmithKline
18821746 10 Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening.EBI University of Innsbruck
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18662876 45 Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.EBI The University of Tokyo
18321611 64 CoMFA analysis of dual/multiple PPAR activators.EBI National Institute of Pharmaceutical Education and Research
18060776 100 Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.EBI GlaxoSmithKline
18029178 188 Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.EBI Eli Lilly and Company
17553681 50 Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety.EBI RE&D VUFB, s.r.o.
17553678 97 Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.EBI Kowa Co.
17532641 57 Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.EBI University of Tokyo
17524643 14 Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.EBI Nagoya City University
17524639 73 Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.EBI Johnson and Johnson Pharmaceutical Research and Development
17512197 101 Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.EBI Pfizer Inc
17498950 69 Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.EBI Pfizer Inc
17379517 45 Design of potent PPARalpha agonists.EBI Novo Nordisk A/S
17343371 27 Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.EBI Novo Nordisk A/S
17157013 74 Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists.EBI Bayer Pharmaceuticals Corporation
17129725 90 Design and synthesis of a novel class of dual PPARgamma/delta agonists.EBI Eli Lilly and Company
17034149 22 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.EBI National Health Research Institutes
16970391 88 Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.EBI Eli Lilly and Company
16797985 26 Studies towards the conception of new selective PPARbeta/delta ligands.EBI Université d'Orléans
16750626 51 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.EBI The Genomics Institute of the Novartis Research Foundation
16737814 112 Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.EBI F. Hoffmann-La Roche Inc
16546385 81 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.EBI The Genomics Institute of the Novartis Research Foundation
16529931 139 SAR studies: designing potent and selective LXR agonists.EBI Merck Research Laboratories
16451087 41 Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.EBI National Health Research Institutes
16384704 86 Design and synthesis of potent and subtype-selective PPARalpha agonists.EBI Merck Research Laboratories
16366601 82 Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.EBI National Health Research Institutes
16275077 27 Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.EBI University of Tokyo
16216504 8 Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents.EBI Novartis Institutes for BioMedical Research
16107159 106 Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.EBI Merck Research Laboratories
15950464 146 (2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents.EBI Merck Research Laboratories
15713415 13 Structure-activity relationships of dimeric PPAR agonists.EBI Novo Nordisk A/S
15603954 37 Benzoyl 2-methyl indoles as selective PPARgamma modulators.EBI Merck Research Laboratories
15582409 46 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.EBI Eli Lilly and Company
15177462 38 Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.EBI Research Institute of Tsinghua University
15163205 94 (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.EBI Merck Research Laboratories
15115385 68 Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.EBI Eli Lilly and Company
14613314 53 Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.EBI Eli Lilly and Company
14584939 32 Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.EBI Novo Nordisk A/S
14505666 99 Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.EBI Merck Research Laboratories
12904063 69 Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.EBI Kyorin Pharmaceutical Co., Ltd
12873517 90 5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.EBI Merck Research Laboratories
12729668 106 5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.EBI Merck Research Laboratories
12699745 49 Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.EBI GlaxoSmithKline
12657263 46 Phenylacetic acid derivatives as hPPAR agonists.EBI Merck Research Laboratories
12617924 140 Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.EBI Merck Research Laboratories
12482434 52 Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.EBI Novo Nordisk A/S
11831892 46 Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.EBI Novo Nordisk A/S
11720854 48 Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.EBI GlaxoSmithKline
11677135 21 Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.EBI GlaxoSmithKline
11527737 70 Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.EBI GlaxoSmithKline
11354382 42 Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.EBI GlaxoSmithKline
10691680 72 The PPARs: from orphan receptors to drug discovery.EBI Glaxo Wellcome Research & Development
10508427 42 A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.EBI Glaxo Wellcome Research & Development
25437304 12 Sterol fatty acid esters from the mushroom Hericium erinaceum and their PPAR transactivational effects.EBI Yeungnam University
24900619 42 Diphenylpropane Derivatives as Agonist of PPAR Nuclear Receptors.EBI Dart Neuroscience LLC
23891183 7 Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.EBI Okayama University
22364952 4 Synthesis and antidiabetic performance of ?-amino ketone containing nabumetone moiety.EBI Southwest University
30296685 86 Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPAR? and PPAR?.EBI Guangdong Pharmaceutical University
30144697 66 Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-? agonists (SERBAs).EBI Marquette University
30054191 66 Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor ? agonist.EBI Daegu-Gyeongbuk Medical Innovation Foundation
29628329 19 Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPAR? selective agonists: New leads for oculovascular conditions.EBI University of Oklahoma
29103972 53 Novel highly selective peroxisome proliferator-activated receptor ? (PPAR?) modulators with pharmacokinetic properties suitable for once-daily oral dosing.EBI Mitobridge, Inc.
28735214 54 Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI Janssen Research and Development LLC
29446942 98 Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.EBI Inventiva
28539218 25 Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists.EBI The University of Tokyo
28799755 51 Polypharmacology of NEBI Sahmyook University
21671327 5 Triptolide directly inhibits dCTP pyrophosphatase.BDB Yale University
8474008 58 Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.BDB Virginia Commonwealth University
19827080 10 A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.BDB University of Cambridge
8461029 21 Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.BDB University of Canterbury
8450829 29 Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.BDB CNRS
8413837 45 [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.BDB Boots Pharmaceuticals
8394987 32 Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.BDB CNRS
19361209 30 Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.BDB Bristol-Myers Squibb Co.