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79 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
10340605 5 Synthesis and evaluation of geldanamycin-estradiol hybrids.EBI Sloan-Kettering Institute for Cancer Research
26395057 48 From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors.EBI Freie Universit£t Berlin
26112442 74 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.EBI Chengdu University of TCM
25799158 6 Volume of Distribution in Drug Design.EBI Pharmacokinetics
25901531 211 Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.EBI Sloan-Kettering Institute for Cancer Research
24984936 28 Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.EBI Tufts University
24980703 296 Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.EBI Nerviano Medical Sciences
24745965 22 Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.EBI Montclair State University
24580531 6 Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.EBI University of Geneva
24763261 35 Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.EBI China Pharmaceutical University
24673104 185 Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.EBI Vertex Pharmaceuticals Inc
23394126 170 Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).EBI Exelixis Inc
23186287 1 Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.EBI Seoul National University
22835870 29 Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.EBI AstraZeneca
23018093 41 Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.EBI Vernalis Ltd
22632933 65 Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.EBI Merck Serono
22386527 23 Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.EBI Serenex Inc.
20055425 29 Heat shock protein 90: inhibitors in clinical trials.EBI Biogen Idec Inc
19405528 45 Potent cytotoxic C-11 modified geldanamycin analogues.EBI Kosan Biosciences Inc
19017562 45 Discovery and development of heat shock protein 90 inhibitors.EBI Memorial Sloan-Kettering Cancer Center
16854066 44 Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.EBI Infinity Pharmaceuticals Inc
22066525 65 Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.EBI Universit£ degli Studi di Ferrara
22014826 3 A small molecule that preferentially binds the closed conformation of Hsp90.EBI San Diego State University
21972823 10 Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.EBI Sanofi-Aventis Research and Development
21920765 12 Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.EBI Trinity College
20608738 7 ATPases as drug targets: insights from heat shock proteins 70 and 90.EBI Vernalis R&D Ltd
19331414 1 Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.EBI Trinity College
18457385 41 Recent developments in fragment-based drug discovery.EBI Astex Therapeutics Ltd
16621545 6 Synthesis of Hsp90 dimerization modulators.EBI Memorial Sloan-Kettering Cancer Center
16530412 13 High-throughput screening for Hsp90 ATPase inhibitors.EBI The University of Kansas
16480864 38 4-Amino derivatives of the Hsp90 inhibitor CCT018159.EBI Vernalis Ltd
16392823 39 Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.EBI Memorial Sloan-Kettering Cancer Center
15828828 136 Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.EBI Memorial Sloan-Kettering Cancer Center
15239664 92 Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.EBI Conforma Therapeutics Corporation
14698151 14 Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.EBI RiboTargets Ltd
14592488 2 Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.EBI Memorial Sloan-Kettering Cancer Center
27818030 5 Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.EBI China Pharmaceutical University
25141341 1 Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors.EBI Montclair State University
24582477 33 Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.EBI China Pharmaceutical University
24548207 14 Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.EBI Memorial Sloan-Kettering Cancer Center
24495105 1 Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.EBI University of California
23859777 5 Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.EBI University of Arizona
23770448 19 Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.EBI University of Salerno
23520985 12 Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.EBI Universit£ di Palermo
23606927 11 3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.EBI The University of Kansas
22877636 60 Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.EBI Exelixis Inc
22913511 91 Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.EBI Myrexis Inc.
21486005 3 Gambogic acid, a natural product inhibitor of Hsp90.EBI Oklahoma State University
21612924 10 Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.EBI Pfizer Inc.
20718493 29 Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.EBI Astex Therapeutics, Ltd.
20655237 8 Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.EBI Universit£ di Milano
20570149 4 Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.EBI The University of Kansas
19908836 11 Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.EBI Pfizer Inc.
19395259 28 Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.EBI Poniard Pharmaceuticals, Inc.
19552433 49 Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.EBI Serenex Inc
18929486 41 Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.EBI Pfizer Inc.
19101151 34 Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.EBI The University of Kansas
18762423 20 Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.EBI Emory University
18571929 45 Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.EBI Emory University
18020309 1 Derrubone, an inhibitor of the Hsp90 protein folding machinery.EBI The University of Kansas
29545103 27 Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).EBI National University of Singapore
29701469 52 Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.EBI University of Vienna
30351001 16 Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.EBI China Pharmaceutical University
28482218 3 Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.EBI China Pharmaceutical University
22591317 5 Impacts of some antibiotics on human serum paraoxonase 1 activity.BDB Atatürk University
14610240 8 Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB).BDB National Institutes of Health
10832613 26 [3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors.BDB Croissy-sur-Seine Paris