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56 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25038482 66 Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists.EBI University of Copenhagen
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc
19962901 2 Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides.EBI University of the West Indies
21498079 45 Development and SAR of functionally selective allosteric modulators of GABAA receptors.EBI AstraZeneca
18537233 108 Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.EBI Moltech Corporation
17470817 12 Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.EBI University of California
16392789 66 Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.EBI Merck Sharp Laboratory
15801854 26 Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.EBI Universit£ di Sassari
10633039 718 Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.EBI University of Wisconsin-Milwaukee
9301675 53 Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.EBI Universit£ degli Studi di Bari
15125950 56 3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.EBI Merck
21277199 29 Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.EBI Novartis Institutes for BioMedical Research
21163663 15 Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.EBI Lund University
20980155 24 Developing dual functional allosteric modulators of GABA(A) receptors.EBI AstraZeneca Pharmaceuticals
20646926 13 The GABA(A) receptor as a target for photochromic molecules.EBI University of Massachusetts
20888240 254 Design, synthesis, and subtype selectivity of 3,6-disubstitutedß-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.EBI University of Wisconsin-Milwaukee
19762240 62 The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.EBI F. Hoffmann-La Roche Inc
19740657 42 Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.EBI F. Hoffmann-La Roche Inc
17544280 50 Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for beta3 over alpha1beta2gamma2 GABA receptors.EBI Shimane University
16610803 40 A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.EBI Merck Sharp & Dohme Research Laboratories
16480260 26 Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.EBI TBA
16386900 50 Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.EBI Merck Sharp and Dohme Research Laboratories
16279764 29 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.EBI Merck Sharp and Dohme Research Laboratories
15743180 404 Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.EBI Merck Sharp & Dohme Research Laboratories
15537339 18 An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.EBI Merck Sharp & Dohme Research Laboratories
15214791 147 Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.EBI Merck Sharp and Dohme Research Laboratories
15177449 31 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.EBI Merck Sharp & Dohme Research Laboratories
15084116 48 Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.EBI Merck Sharp and Dohme Research Laboratories
15027873 247 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.EBI Merck Sharp and Dohme Research Laboratories
15026049 42 Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.EBI The Neuroscience Research Centre
15006383 12 Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis.EBI University of Wisconsin-Milwaukee
14667209 32 Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist.EBI University of Wisconsin-Milwaukee
12747794 124 Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.EBI Merck Sharp & Dohme Research Laboratories
12408715 97 Synthesis and biological evaluation of 7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as functionally selective ligands of the benzodiazepine receptor site on the GABA(A) receptor.EBI Neurogen Corporation
11960500 109 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.EBI Merck Sharp & Dohme Research Laboratories
11881985 48 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.EBI Merck Sharp & Dohme Research Laboratories
11412984 66 Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.EBI The Royal Danish School of Pharmacy
10890169 48 N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit.EBI Merck Sharp & Dohme Research Laboratories
9767648 275 Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.EBI University of Wisconsin-Milwaukee
9651158 158 Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptorsEBI University of Wisconsin-Milwaukee
8627617 47 Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.EBI University of Wisconsin-Milwaukee
24905252 17 Efficient modulation of ?-aminobutyric acid type A receptors by piperine derivatives.EBI University of Vienna
24462176 3 Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators.EBI University of Basel
21751815 4 New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.EBI Universit£ degli Studi di Siena
28606760 57 Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.EBI Amgen Inc.
29336873 4 Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.EBI Novartis Institutes for BioMedical Research
29146472 71 Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.EBI Roche Pharma Research and Early Development
27933953 23 Synthesis and Characterization of a Novel?-Aminobutyric Acid Type A (GABAEBI University of Wisconsin-Milwaukee
26214255 11 The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.BDB University of British Columbia
25636004 12 Structure-guided design of a high affinity inhibitor to human CtBP.BDB University of Massachusetts Medical School