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81 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25427005 42 Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.EBI University of California-San Francisco
25127103 4 Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.EBI Yale University
430474 2 trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.EBI TBA
24531230 34 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.EBI Universit£ degli Studi di Sassari
24147825 22 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.EBI University of Modena and Reggio Emilia
24125851 48 Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation.EBI University of Mansoura
23665106 5 Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline.EBI Capital Normal University
23490159 13 Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.EBI Nanjing University
23273520 93 Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.EBI Universit£ degli Studi di Modena e Reggio Emilia
20153089 97 3D-QSAR studies on quinazoline antifolate thymidylate synthase inhibitors by CoMFA and CoMSIA models.EBI Meerut Institute of Engineering and Technology
1895294 14 Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.EBI University of South Alabama
2909728 5 Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition.EBI Pedagogical University
23075414 7 Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.EBI Universit£ degli Studi di Perugia
22946585 19 Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.EBI Universita` degli Studi di Sassari
22739090 86 Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.EBI Duquesne University
20092323 23 Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.EBI Duquesne University
20056546 100 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.EBI Duquesne University
19059777 3 Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.EBI Yale University
18800768 84 Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates.EBI Duquesne University
18605720 120 The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.EBI Duquesne University
18362071 3 A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.EBI Polish Academy of Sciences
15615538 28 Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.EBI Duquesne University
15615522 17 Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.EBI Duquesne University
16078850 41 Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.EBI Duquesne University
15837298 62 Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.EBI Duquesne University
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
12570380 34 Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.EBI Duquesne University
11384244 61 Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.EBI Duquesne University
11052789 49 Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.EBI Duquesne University
10956221 46 Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.EBI Duquesne University
8917645 20 Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.EBI University of Minnesota
8917644 49 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.EBI Duquesne University
8164249 46 Application of the three-dimensional structures of protein target molecules in structure-based drug design.EBI Abbott Laboratories
1578484 26 Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.EBI Harvard Medical School
2642553 5 Rational design of enzyme inhibitors: multisubstrate analogue inhibitors.EBI University of Utah
3373483 39 Linear free energy relationship studies of enzyme active site binding: thymidylate synthase.EBI University of Kansas
3184122 10 A pyrimidine-based"flexible" bisubstrate analogue inhibitor of human thymidylate synthase.EBI University of Utah
3470522 16 Folate analogues as inhibitors of thymidylate synthase.EBI TBA
3091832 28 Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).EBI TBA
6502602 9 A potent multisubstrate analogue inhibitor of human thymidylate synthetase.EBI TBA
21550809 44 Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.EBI Duquesne University
21696158 50 Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.EBI Universita degli Studi di Modena e Reggio Emilia
21080724 57 Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).EBI Myrexis, Inc.
20951595 1 Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.EBI Università degli Studi di Perugia
20527892 7 Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.EBI Institute of Theoretical Studies gGmbH
20163895 1 Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines.EBI University College of Pharmaceutical Sciences
 4 Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structureEBI TBA
17532099 30 Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.EBI Università degli Studi di Sassari
15715461 18 Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.EBI Università degli Studi di Modena e Reggio Emilia
11960504 14 Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate.EBI Duquesne University
10377234 12 Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase.EBI Duquesne University
9990460 9 The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents.EBI Lilly Research Laboratories
9057854 41 Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.EBI Agouron Pharmaceuticals, Inc.
8459400 74 Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.EBI Agouron Pharmaceuticals, Inc.
8360872 3 Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones.EBI Wellcome Research Laboratories
8230138 15 Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.EBI Wellcome Research Laboratories
8164259 44 Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.EBI Duquesne University
8145235 9 Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.EBI Wellcome Research Laboratories
7783121 20 Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.EBI Agouron Pharmaceuticals, Inc.
7562910 18 Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.EBI Duquesne University
7473577 11 5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.EBI Duquesne University
6434741 2 Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase.EBI TBA
3746818 1 Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate.EBI TBA
2542557 14 Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.EBI University of South Alabama
2066965 28 Design of enzyme inhibitors using iterative protein crystallographic analysis.EBI Agouron Pharmaceuticals, Inc.
1995884 4 Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid.EBI Duquesne University
1995868 4 The renewed potential for folate antagonists in contemporary cancer chemotherapy.EBI Parke-Davis Pharmaceutical Research Division
1732551 6 Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.EBI Southern Research Institute
1548676 28 Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.EBI Agouron Pharmaceuticals, Inc.
1433179 13 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.EBI Duquesne University
9247853 7 Yeast hexokinase inhibitors designed from the 3-D enzyme structure rebuilding.BDB Groupe de Chimie Organique Biologique