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307 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28657744 167 Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.EBI University of Illinois at Chicago
28244748 119 The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.EBI Virginia Commonwealth University
8258822 102 Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.EBI University of Georgia
8515429 16 (+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor.EBI SmithKline Beecham Pharmaceuticals Ltd
1992127 6 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines.EBI Purdue University
2342076 34 Syntheses and platelet aggregation inhibitory and antithrombotic properties of [2-[(omega-aminoalkoxy)phenyl]ethyl]benzenes.EBI Mitsubishi Kasei Corporation
2308135 28 A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors.EBI Virginia Commonwealth University
2457705 14 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists.EBI Eli Lilly and Company
2456389 40 Ergolines as selective 5-HT1 agonists.EBI Eli Lilly and Company
3385733 28 Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors.EBI Purdue University
3572981 12 N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.EBI TBA
3701781 14 Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents.EBI TBA
3950904 26 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues.EBI TBA
3783602 22 2,3-Dialkyl(dimethylamino)indoles: interaction with 5HT1, 5HT2, and rat stomach fundal serotonin receptors.EBI TBA
3783595 14 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.EBI TBA
12467617 17 New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability.EBI Meiji Seika Kaisha, Ltd
27639363 141 Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.EBI Huazhong University of Science and Technology
27448773 16 Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.EBI Tokyo Medical and Dental University (TMDU)
27061981 22 5-HT2 receptor affinity, docking studies and pharmacological evaluation of a series of 1,3-disubstituted thiourea derivatives.EBI Medical University of Warsaw
26820556 156 Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.EBI Dipartimento di Farmacia Universit£ di Napoli"Federico II"
26748694 44 The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.EBI Gedeon Richter Plc
26483200 100 Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.EBI Huazhong University of Science and Technology
26023814 79 Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.EBI IQM-CSIC
25936259 55 Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.EBI Jagiellonian University Medical College
25435254 82 Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.EBI Jagiellonian University Medical College
25343529 221 Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.EBI Universit£ degli Studi di Siena
24800940 146 Identification of a new selective dopamine D4 receptor ligand.EBI Florida A&M University
24618300 28 Synthesis and biological evaluation of a series of benzoxazole/benzothiazole-containing 2,3-dihydrobenzo[b][1,4]dioxine derivatives as potential antidepressants.EBI Huazhong University of Science and Technology
23353740 21 Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.EBI Universidade Federal de Goi£s
7932524 38 Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin- 2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor.EBI Merck Sharp & Dohme Research Laboratories
3373482 50 Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.EBI Merrell Dow Research Institute
 18 Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine.EBI TBA
19846239 24 Application of desirability-based multi(bi)-objective optimization in the design of selective arylpiperazine derivates for the 5-HT1A serotonin receptor.EBI University of Porto
11754579 82 New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.EBI Universidad de Santiago de Compostela
10737740 57 Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.EBI Freie Universit£t Berlin
10052973 36 Cycloalkanecarboxylic esters derived from lysergol, dihydrolysergol-I, and elymoclavine as partial agonists and antagonists at rat 5-HT2A receptors: pharmacological evidence that the indolo[4,3-fg]quinoline system of the ergolines is responsible for high 5-HT2A receptor affinity.EBI Freie Universit£t Berlin
8709108 28 Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.EBI Eli Lilly and Company
7752204 98 Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.EBI Merck Sharp & Dohme Research Laboratories
8496922 92 Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.EBI Merck Sharp and Dohme Research Laboratories
12482418 18 New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors.EBI University of Santiago
11454468 35 Discovery and SAR of org 24598-a selective glycine uptake inhibitor.EBI Organon Research and Development Group
9934473 16 Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.EBI Universidad de Santiago de Compostela
 1 Synthesis, biological in vitro evaluation and stereoselectivity of ondansetron analogues: novel 5-HT2A receptor antagonistsEBI TBA
22386241 46 Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.EBI SK Biopharmaceuticals
21816515 93 Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.EBI Medical University of Warsaw
20931963 112 Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI ASKA Pharmaceutical Co., Ltd
20153652 49 Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.EBI Universidade Federal do Rio Grande do Sul
19831400 47 Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.EBI European Research Centre for Drug Discovery and Development (NatSynDrugs)
19560916 39 Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.EBI Jagiellonian University Medical College
18603331 73 The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.EBI Jagiellonian University Medical College
9214741 4 Activity of Parthenolide at 5HT2A receptors.EBI University of Montana
18187324 5 Total synthesis and evaluation of [18F]MHMZ.EBI University of Mainz
17517514 63 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.EBI Jagiellonian University Medical College
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15801844 25 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI Universidad Complutense
15357957 29 Synthesis, receptor binding and functional studies of mesoridazine stereoisomers.EBI Brigham & Women's Hospital
14640559 405 Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.EBI Faes Farma SA
12519065 243 Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.EBI H. Lundbeck A/S
12954071 109 A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.EBI Alcon Research Ltd
12361392 62 Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.EBI Universit£ degli Studi di Sassari
11784153 125 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.EBI Merck Sharp and Dohme Research Laboratories
11784139 82 Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.EBI Universit£ degli Studi di Siena
12213075 70 Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).EBI Purdue University
11170639 73 Current and novel approaches to the drug treatment of schizophrenia.EBI Merck Sharp and Dohme Research Laboratories
10229626 66 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.EBI Universit£ di Siena
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI Universit£ di Siena
9599242 23 (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.EBI Astra Arcus AB
9357534 49 Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.EBI Universit£ di Siena
8960552 58 Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.EBI Universit£ di Bari
7707322 52 Ketanserin analogues: the effect of structural modification on 5-HT2 serotonin receptor binding.EBI Virginia Commonwealth University
7861418 61 Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.EBI Vanderbilt University
7629808 64 Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.EBI Universit£ di Siena
7783131 78 Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.EBI H. Lundbeck A/S
8246241 34 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.EBI University of Pennsylvania
8410990 141 Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.EBI H. Lundbeck A/S
1573641 60 SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI Searle Research and Development
1542100 67 Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.EBI Virginia Commonwealth University
1346653 168 Pyrrole mannich bases as potential antipsychotic agents.EBI R. W. Johnson Pharmaceutical Research Institute
1479590 73 Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.EBI Virginia Commonwealth University
1361578 99 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI Bristol-Myers Squibb Co.
1908521 106 Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.EBI Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer
1672156 81 Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.EBI Hoechst-Roussel Pharmaceuticals Inc
1995885 15 Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.EBI Dainippon Pharmaceutical Company, Ltd.
1833546 47 Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.EBI Abbott Laboratories
1671416 15 Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones.EBI Warner-Lambert Company
2258903 23 Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.EBI Eli Lilly and Company
2542551 89 The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.EBI Bristol-Myers Company
2903929 143 Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.EBI H. Lundbeck A/S
3039136 328 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
2889830 26 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1.EBI Duphar Research Laboratories
2888898 41 Antipsychotic activity of substituted gamma-carbolines.EBI Wyeth Laboratories, Inc.
3543362 184 Central serotonin receptors as targets for drug research.EBI TBA
2874226 27 Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives.EBI TBA
2869146 72 Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.EBI TBA
11078200 61 N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists.EBI Welfide Corporation
10843230 20 Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity.EBI Yale University
 24 1,1-diphenyl-3-dialkylamino-1-silacyclopentane derivatives: A new class of potent and selective 5-HT2A antagonistsEBI TBA
14695828 107 Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.EBI Universit£ degli Studi di Siena
22277589 72 Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.EBI Jagiellonian University Medical College
22133459 56 New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.EBI Universit£ di Napoli"Federico II"
22029386 156 New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.EBI Universidad Complutense de Madrid
22001327 77 Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.EBI Jagiellonian University Medical College
21440338 36 Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents.EBI Universit£ di Napoli Federico II
20684606 68 Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia.EBI Arena Pharmaceuticals
20481570 81 Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.EBI Universita di Siena
20363131 4 Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.EBI Universidade Federal de Goi£s
20347301 32 New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation.EBI Universit£ di Napoli Federico II
20060623 30 Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity.EBI Jagiellonian University Medical College
19914063 84 Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.EBI Pfizer Inc
19679379 33 Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.EBI Jagiellonian University Medical College
19954866 31 Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.EBI Universit£ di Napoli
 49 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI TBA
 52 Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.EBI TBA
 53 5-HT1A and 5-HT2A ligands with anxiolytic and antipanic-like propertiesEBI TBA
 21 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonistsEBI TBA
 43 2-[4-(o-methoxyphenyl)piperazin-1-ylmethyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine as a new selective 5-HT1A receptor ligandEBI TBA
 58 Synthesis and serotonin receptor binding properties of 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indolesEBI TBA
 50 Synthesis and evaluation of n-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives as potential anti-ischemic agentsEBI TBA
19425598 61 Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.EBI European Research Centre for Drug Discovery and Development (NatSynDrugs)
19329329 183 Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19072656 110 Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.EBI University of Siena
18598015 53 Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.EBI Università di Catania
18467103 18 'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.EBI University of Wisconsin-La Crosse
18296055 26 The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.EBI Purdue University
17976986 80 Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.EBI Pfizer Inc
17900912 15 1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.EBI Università di Milano
17543523 17 R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.EBI Harvard Medical School
17419053 49 Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.EBI Alcon Research Ltd
17328523 36 Novel sigma receptor ligands: synthesis and biological profile.EBI University of Catania
17321139 48 Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.EBI University of Montpellier
17254782 28 Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.EBI Faculté des Sciences Pharmaceutiques et Biologiques de Lille
17251022 48 Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.EBI Université du Droit et de la Santé Lille II
17234413 4 Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines.EBI Central Drug Research Institute
16971119 35 Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands.EBI Merck Sharp and Dohme Research Laboratories
16970404 22 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.EBI Purdue University
16821786 13 C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.EBI Purdue University
16392816 113 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.EBI Alcon Research Ltd
16107148 44 New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.EBI Università di Napoli "Federico II"
16061378 87 SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.EBI Organix Inc
15993598 55 4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.EBI Merck Sharp and Dohme Research Laboratories
15771414 36 Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.EBI Università di Siena
15588097 95 Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.EBI Università degli Studi di Bari
15537358 26 Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.EBI Virginia Commonwealth University
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15115407 8 New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.EBI Collegium Medicum of the Jagiellonian University
15013010 9 Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.EBI Virginia Commonwealth University
15013009 28 Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.EBI Virginia Commonwealth University
14643338 124 Binding of beta-carbolines at 5-HT(2) serotonin receptors.EBI Virginia Commonwealth University
12930153 128 Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.EBI Virginia Commonwealth University
12877591 36 Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.EBI Purdue University
12852967 15 Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.EBI Virginia Commonwealth University
12668005 21 Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI Universidad Complutense
12570387 60 Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI Università degli Studi di Bari
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12408724 79 New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.EBI University of Liège
12113827 7 Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity.EBI Purdue University
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI University Center for Pharmacy
11934576 85 Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.EBI Université de Lille 2
11755343 54 Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.EBI Virginia Commonwealth University
11689074 112 N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.EBI Merck Sharp & Dohme Research Laboratories
11563927 75 1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.EBI Virginia Commonwealth University
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI Universidad de Navarra
11354383 24 Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.EBI Polish Academy of Sciences
11300881 45 Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.EBI Purdue University
11277522 7 A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties.EBI Purdue University
11229772 16 Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.EBI Virginia Commonwealth University
11101361 37 Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.EBI Purdue University
11055342 21 N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.EBI Virginia Commonwealth University
10956215 52 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists.EBI Virginia Commonwealth University
10956192 31 Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor.EBI AstraZeneca R&D Södertälje
10821703 8 Application of similarity matrices and genetic neural networks in quantitative structure-activity relationships of 2- or 4-(4-Methylpiperazino)pyrimidines: 5-HT(2A) receptor antagonists.EBI Jagiellonian University
10743959 48 N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.EBI Yoshitomi Pharmaceutical Industries Ltd
10715164 57 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.EBI Virginia Commonwealth University
10514296 8 Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain.EBI Purdue University
10464021 59 N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI Knoll Pharmaceuticals
10377229 107 New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.EBI University of Göteborg
10360740 35 N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.EBI POSTECH
9986714 105 Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists.EBI Recordati S.p.A.
9986703 7 Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT2A and alpha1 receptor binding affinity.EBI Angelini Ricerche S.p.A.
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI Centro de Investigación Grupo Ferrer
9873609 15 NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.EBI Neurogen Corporation
9871719 144 Serotonergic ergoline derivatives.EBI Pharmacia & Upjohn
9871525 56 Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.EBI R. W. Johnson Pharmaceutical Research Institute
9857084 11 A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor.EBI Purdue University
9836624 64 Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.EBI Virginia Commonwealth University
9622555 25 Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.EBI Purdue University
9406603 49 Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.EBI University of Groningen
9301661 32 Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.EBI Purdue University
9276014 62 Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.EBI Warner-Lambert Company
9046348 45 [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.EBI Università di Catania
8893838 106 Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.EBI Universidad Complutense
8809161 90 Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.EBI H. Lundbeck A/S
8709129 18 Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.EBI Purdue University
8709107 99 Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.EBI Yamanouchi Pharmaceutical Company Limited
8568801 13 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.EBI Pfizer Inc
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc
8496920 14 (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.EBI Wyeth Research (UK)
8355253 74 Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.EBI Virginia Commonwealth University
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8101877 80 New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.EBI University of Liège
8064797 118 Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.EBI Vanderbilt University
7914536 96 Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.EBI Hoechst-Roussel Pharmaceuticals Inc
7901415 36 Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics.EBI Scios Nova Inc
7699712 20 Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.EBI Purdue University
7473566 152 Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.EBI H. Lundbeck A/S
6581313 2 Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.EBI TBA
3746815 15 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI TBA
2965244 32 N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.EBI Virginia Commonwealth University
2902227 10 Serotonergic properties of spiroxatrine enantiomers.EBI University of Arizona
2902226 39 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2.EBI Duphar Research Laboratories
2892936 21 Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.EBI Warner-Lambert Company
2875184 57 (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.EBI TBA
2565400 132 Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.EBI McNeil Pharmaceutical and Janssen Research Foundation Worldwide
2537429 61 2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.EBI Ciba-Geigy Corporation
2374139 50 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.EBI Pfizer Inc
2299641 24 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.EBI Virginia Commonwealth University
2213830 30 Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.EBI Virginia Commonwealth University
1683407 32 Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
1676758 12 Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.EBI H. Lundbeck A/S
1652026 43 Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.EBI Virginia Commonwealth University
1652023 179 Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.EBI Abbott Laboratories
1534585 8 Benzofuran bioisosteres of hallucinogenic tryptamines.EBI Purdue University
1531364 42 Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.EBI University of Pennsylvania
1447752 28 Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.EBI Pfizer Inc
1433172 30 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.EBI Pfizer Inc
1353116 10 3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.EBI Hoechst-Roussel Pharmaceuticals Inc
1348090 64 Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.EBI H. Lundbeck A/S
1336054 63 Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.EBI H. Lundbeck A/S
1336053 86 Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.EBI H. Lundbeck A/S
26851737 36 One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.BDB University of Karachi
26218629 26 Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).BDB Oregon Health & Science University
26214585 23 Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.BDB University of Wisconsin-Madison
26119990 19 Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors.BDB University of Karachi
25462625 58 Salicylanilide diethyl phosphates as cholinesterases inhibitors.BDB Charles University in Prague
10747922 12 Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.BDB Swiss Federal Institute of Technology