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193 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28038322 38 Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.EBI Beni-Suef University
3488405 12 Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.EBI TBA
28057407 76 Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI Georgia Institute of Technology
27916468 36 Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.EBI Beni-Suef University
27842798 66 Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.EBI Wroclaw Medical University
27720548 16 Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.EBI Kyung Hee University
27191614 4 The therapeutic voyage of pyrazole and its analogs: A review.EBI Jamia Hamdard
27131067 24 Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.EBI Beni-Suef University
27325447 6 Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells.EBI Tohoku Medical and Pharmaceutical University
27344214 16 Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.EBI King Saud University
27019010 48 Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.EBI Guru Nanak Dev University
26999325 30 Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.EBI King Saud University
26898334 16 Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.EBI University of Alberta
26774927 120 Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.EBI Fondazione Istituto Italiano di Tecnologia
27025563 12 Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.EBI University of Mansoura
26850006 10 Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.EBI University of Alberta
26691756 38 Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.EBI Beni-Suef University
26455657 12 Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.EBI Tohoku Pharmaceutical University
26316467 2 Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.EBI Hunan University of Chinese Medicine
26117820 18 Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.EBI Indian Institute of Technology (Banaras Hindu University)
26081289 14 Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors.EBI Technische Universitat Dresden
25956953 51 Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.EBI Guru Nanak Dev University
25768707 17 General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.EBI Universit£ degli Studi di Bari"A.Moro"
25980909 16 Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.EBI Chinese Academy of Sciences
25549551 66 Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.EBI King Saud University
25868745 16 Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.EBI Hacettepe University
25819096 16 Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.EBI Hunan University of Chinese Medicine
25575659 124 SAR-studies of┐-secretase modulators with PPAR┐-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI Goethe-University Frankfurt
25147154 18 Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.EBI Dokki
25016374 31 Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.EBI Griffith University
24938495 75 Pharmacological evaluation and docking studies ofa,▀-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.EBI Universiti Kebangsaan Malaysia
24631898 17 Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.EBI Guru Nanak Dev University
24576797 8 Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.EBI National Research Centre, Dokki
25462246 20 Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.EBI Anadolu University
25444084 40 Synthesis of novel pyrazole?thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI KLE University
25408841 108 Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.EBI Vanderbilt University School of Medicine
25221653 24 Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.EBI Minia University
25219899 16 Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.EBI National Institute of Pharmaceutical Education and Research
24983538 16 Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.EBI Minia University
24900871 8 2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.EBI National Institute of Pharmaceutical Education and Research (NIPER)
24844534 46 Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.EBI University of Tuebingen
24780593 46 Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.EBI Shoolini University
24763362 22 Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.EBI National Institute of Pharmaceutical Education and Research
24751552 20 Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.EBI K.L.E.U's College of Pharmacy
24656662 33 Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI Kyung Hee University
24650702 16 Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.EBI Keio University
24631895 14 1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.EBI Minia University
24631365 10 Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.EBI Cairo University
23219856 7 Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.EBI Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki
23200247 30 Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.EBI University of Alberta
12383007 100 Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.EBI Chinese Academy of Sciences
23043222 125 Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.EBI Istituto Italiano di Tecnologia
22916727 18 Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.EBI Hokkaido University
23010270 25 Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.EBI University of Hyderabad Campus
21800856 50 Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI University of Innsbruck
23047224 24 Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.EBI Hacettepe University
22560838 7 Radiosynthesis of a¹8F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.EBI Helmholtz-Zentrum Dresden-Rossendorf
22091869 6 Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.EBI Faculdade de Ci�ncias e Tecnologia-UNL
22516672 47 Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.EBI University of Mansoura
22475926 39 Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.EBI University of Hacettepe
21280601 18 Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.EBI University of Alberta
21318094 25 [I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.EBI TBA
20188577 23 In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.EBI King's College London
19880317 50 COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.EBI Universidad Nacional de Colombia
19500994 18 Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
19053751 89 Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.EBI Eberhard-Karls-University Tuebingen
15568761 18 Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study.EBI University of Pennsylvania School of Medicine
18272371 50 Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.EBI Temple University School of Medicine
17434872 38 Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.EBI Vanderbilt Institute for Chemical Biology
18023187 32 Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.EBI University of Alberta
18096394 22 Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.EBI University of Alberta
16143531 58 Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.EBI University of Alberta
15780608 12 Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.EBI National Institute of Pharmaceutical Education and Research (NIPER)
14584938 48 Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.EBI University of Alberta
8831759 16 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.EBI SmithKline Beecham Pharmaceuticals
7562922 48 Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.EBI DuPont Merck Pharmaceutical Company
 35 Antiinflammatory -benzeneethanamines. IIIEBI TBA
22386983 25 Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).EBI University of Alberta
22361134 26 N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.EBI University of Alberta
22341941 34 Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.EBI University of Alberta
22148253 12 Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.EBI University of Alberta
22119153 64 Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.EBI Alexander Technological Education Institute of Thessaloniki
21890358 30 Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.EBI University of Alberta
21843935 2 Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.EBI Universit£ 'G. D'Annunzio' di Chieti-Pescara
21873070 29 SAR studies of acidic dual¿-secretase/PPAR¿ modulators.EBI Goethe-University Frankfurt
21739938 72 Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.EBI National Human Genome Research Institute
21641217 10 A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
19447036 12 Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI Shahid Beheshti University (M.C)
21570309 42 Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.EBI University of Mansoura
21524587 6 Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.EBI Universit£t Leipzig
21319773 8 Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.EBI University of Veterinary and Pharmaceutical Sciences Brno
21388719 54 Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.EBI King Saud University
21349729 44 Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.EBI Sun Yat-Sen University
21316237 12 Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors.EBI University of Alberta
21144750 30 Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors.EBI Nanjing University
20961090 6 Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2.EBI Tokushima Bunri University
20727750 9 Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.EBI University of Alberta
20804197 40 Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.EBI Universitat de Barcelona
20691338 24 Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.EBI Shahid Beheshti University of Medical Sciences
20692174 12 Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.EBI Gazi University
20655211 18 Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.EBI University of Alberta
20576432 16 Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
20527891 7 Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.EBI Purdue University
20503989 29 Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.EBI ZAFES/LiFF/Goethe University Frankfurt
20387815 40 Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.EBI Guru Nanak Dev University
20236826 6 Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.EBI University of Graz
20202839 13 Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.EBI University of Alberta
20129783 30 Podophyllotoxin analogues active versus Trypanosoma brucei.EBI Vanderbilt University School of Medicine
20045320 14 Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI University of Alberta
20097072 14 Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
20061161 12 Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.EBI Shahid Beheshti University MC
19560931 15 Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.EBI Shahid Beheshti University (M.C)
19457595 12 Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.EBI Hamdard University
19592244 61 7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.EBI Novartis Institutes of Biomedical Research
19481465 31 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.EBI Karl-Franzens-Universit£t Graz
19596198 14 Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI Shahid Beheshti University (M.C)
 50 Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitorsEBI TBA
 10 Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agentsEBI TBA
19419861 18 Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
19136259 14 Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI University of Alberta
19084295 5 Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.EBI Gazi University
18945614 8 Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI University of Alberta
18930406 12 Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.EBI University of Alberta
18835505 15 Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.EBI Guru Nanak Dev University
16792405 11 Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.EBI Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos
16252923 4 Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).EBI Fr. 8.2 Pharmakognosie und Analytische Phytochemie der Universität des Saarlandes
15679320 12 Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.EBI Tokushima Bunri University
10757731 3 Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta.EBI Columbia University
18226898 12 Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI Shaheed Beheshti University of Medical Sciences
18072726 4 New celecoxib derivatives as anti-inflammatory agents.EBI Gedeon Richter Plc
18061444 7 1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.EBI Guru Nanak Dev University
17937989 6 Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors.EBI The University of the West Indies
17764958 18 Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.EBI University of Alberta
17604631 22 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.EBI University of Vienna
17509888 12 O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.EBI National Cancer Institute at Frederick
17258905 22 Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.EBI Tehran University of Medical Sciences
17079150 14 Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.EBI Okayama University Graduate School of Medicine
17067801 14 Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.EBI University of Alberta Edmonton
16806914 6 Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.EBI Tehran University of Medical Sciences
15943479 18 Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.EBI University of Alberta
15887968 13 Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.EBI Vanderbilt University
15603969 40 Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.EBI University of Alberta
15537365 20 A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.EBI University of Alberta
15369391 3 Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.EBI Telik, Inc.
15341950 14 A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.EBI University of Alberta
15267236 72 Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.EBI University of Alberta
15050636 14 Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.EBI University of Alberta
15050635 18 Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI University of Alberta
15026050 31 Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.EBI Discovery Research-Dr Reddy's Laboratories Ltd
15013005 4 Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.EBI National Institute of Pharmaceutical Education and Research
14741265 15 Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.EBI Drexel University College of Medicine
14698190 44 Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.EBI Discovery Research-Dr. Reddy's Laboratories Ltd
14698178 8 1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors.EBI Dr. Reddy's Laboratories Limited
12954051 10 Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.EBI Dr Reddy's Laboratories Ltd.
12798335 22 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.EBI University of Alberta
12127515 29 SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.EBI Novartis Pharma AG
11965379 94 Enantiospecific, selective cyclooxygenase-2 inhibitors.EBI Vanderbilt University School of Medicine
11909713 42 Thalidomide and its analogues as cyclooxygenase inhibitors.EBI The University of Tokyo
11844663 54 Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.EBI Vanderbilt University School of Medicine
10956194 152 Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.EBI Vanderbilt University School of Medicine
10866395 33 SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.EBI Novartis Pharma AG
10230624 110 N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.EBI The R.W. Johnson Pharmaceutical Research Institute
10230611 48 Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.EBI The DuPont Pharmaceutical Company
10091674 36 Structure-based design of COX-2 selectivity into flurbiprofen.EBI Merck Frosst Canada Inc.
9822550 98 Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.EBI Center in Molecular Toxicology and The Vanderbilt Cancer Center
9484493 11 Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.EBI OXIS International, Inc.
8246226 89 Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.EBI Ciba-Geigy Corporation
3930740 60 Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.EBI TBA
3081722 47 Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.EBI TBA
21774747 6 Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and ▀-glucuronidase inhibitory activity of transformed products.BDB University of Karachi
21699374 15 Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI.BDB Agri Ibrahim ăešen University
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