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50 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
24946214 24 Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.EBI Universit£ degli Studi di Messina
24561716 18 Identification of a new series of amides as non-covalent proteasome inhibitors.EBI Universit£ degli Studi di Messina
24102612 105 Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.EBI University of Bari "Aldo Moro"
22770607 54 Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.EBI Virginia Commonwealth University
14640539 112 Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).EBI Pharmaceutical Research Institute
14521410 36 Identification and prediction of promiscuous aggregating inhibitors among known drugs.EBI Northwestern University
11931626 124 A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.EBI Northwestern University
12190311 37 Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).EBI GSK
11312927 64 Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.EBI Welfide Corporation
10579821 51 Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.EBI Novartis Horsham Research Centre
2296008 13 Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.EBI Merrell Dow Research Institute
 24 L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitorEBI TBA
22377673 4 Proteasome inhibitors for cancer therapy.EBI Cephalon Inc.
20945905 4 Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids asß-lactamase inhibitors.EBI University of California San Francisco
20020755 2 Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.EBI Smithsonian Marine Station at Ft. Pierce
 46 1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhi...EBI TBA
 9 Diphenylborinic acid is a strong inhibitor of serine proteasesEBI TBA
 2 Stereochemical approach for enzyme inhibitor designEBI TBA
 4 Engineering of cyclic peptides with novel inhibiting properties to differentiate two serine proteases, chymotrypsin and subtilisin CarlsbergEBI TBA
 2 Boric acid effect ont he hydrolysis of 4-nitrophenyl 2,3-dihydroxybenzoate: mimic of borate inhibition of serine proteasesEBI TBA
 7 Janus compounds: dual inhibitors of proteinasesEBI TBA
 12 MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.EBI TBA
 5 Borinic acid inhibitors as probes of the factors involved in binding at the active sites of subtilisin carlsberg and α-chymotrypsinEBI TBA
14684338 44 P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.EBI Lilly Research Laboratory
12593666 30 Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.EBI Senju Pharmaceutical Co.
11549442 6 Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin.EBI University of Canterbury
11078188 20 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.EBI Shionogi & Co., Ltd
10866385 13 Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.EBI The Oxford Centre for Molecular Sciences
10698435 150 Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.EBI Kyoto Pharmaceutical University
9925737 57 N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.EBI Nippon Steel Corporation
9871686 23 Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.EBI Glaxo Wellcome Research and Development
9871511 54 Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.EBI Green Cross Research Laboratories
9804697 61 Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.EBI Northwestern University Medical School
9767628 31 Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.EBI GlaxoWellcome Medicines Research Centre
9703466 35 Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.EBI Merck Research Laboratories
9667976 58 beta-Lactam derivatives as inhibitors of human cytomegalovirus protease.EBI Boehringer Ingelheim (Canada) Ltd.
9406601 109 Peptidomimetic inhibitors of the human cytomegalovirus protease.EBI Boehringer Ingelheim Ltd.
9216834 153 Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.EBI Suntory Ltd.
8691456 7 Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the"aromatic" nature of the novel ester-type coumarin for strong inhibitory activity.EBI Université de Liège
7837244 33 Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.EBI ZENECA Pharmaceuticals
7739010 118 Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.EBI Thrombosis Research Institute
7629790 32 New orally active serine protease inhibitors.EBI Minase Research Institute
7562931 41 Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.EBI ZENECA Pharmaceuticals
3941405 15 Carboxyl-modified amino acids and peptides as protease inhibitors.EBI TBA
2391691 51 Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.EBI Merck Sharp and Dohme Research Laboratories
2187995 6 O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism.EBI State University
1447734 19 Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.EBI University of Illinois
27775715 113 Design and characterization of bivalent BET inhibitors.BDB Dana-Farber Cancer Institute
10869410 62 S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.BDB Centre de Recherches de Croissy