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33 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25937878 9 The chemistry and pharmacology of privileged pyrroloquinazolines.EBI Oregon Health& Science University
8201595 12 Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.EBI Eisai Company, Ltd.
1995880 8 Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.EBI Harvard Medical School
2898531 20 Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.EBI Harvard Medical School
3385730 13 Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.EBI Harvard Medical School
3351853 5 Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.EBI Institute
3112397 5 Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.EBI TBA
3462394 12 Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.EBI TBA
2423690 15 Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.EBI TBA
2871191 11 Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.EBI TBA
7108907 11 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.EBI TBA
7143361 6 Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.EBI TBA
12825924 8 Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.EBI University of Minnesota
8863812 8 Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.EBI State University of New York
8340923 7 Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.EBI SRI International
8277497 17 Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.EBI Southern Research Institute
7057425 13 Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.EBI TBA
6737432 4 Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.EBI TBA
4045922 4 Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.EBI TBA
4020824 11 Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.EBI TBA
3968685 7 Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.EBI TBA
3754284 13 Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.EBI TBA
3712374 25 Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.EBI TBA
3385729 7 Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.EBI Harvard Medical School
3373490 7 Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).EBI Cornell University
3184124 28 Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.EBI Southern Research Institute
2428979 11 Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.EBI TBA
2299633 6 Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.EBI SRI International
2296020 18 Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.EBI SRI International
1732551 6 Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.EBI Southern Research Institute
1732549 4 Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.EBI SRI International
1501226 2 Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).EBI Southern Research Institute
11082453 77 ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.BDB Abbott Laboratories