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44 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
10450960 3 Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum.EBI Schering-Plough Research Institute
17113777 1 Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.EBI Uppsala University
16078825 8 Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.EBI Schering Plough Research Institute
15633995 66 Control of hepatitis C: a medicinal chemistry perspective.EBI University of Wollongong
15546725 3 Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease.EBI Peking University
15357995 18 SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease.EBI Merck Research Laboratories
11206459 29 Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.EBI Uppsala University
11055336 2 NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain.EBI Boehringer Ingelheim
11055335 27 Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.EBI Boehringer Ingelheim
9873421 30 Peptide-based inhibitors of the hepatitis C virus serine protease.EBI Boehringer Ingelheim (Canada) Ltd.
16730985 13 P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.EBI Schering Plough Research Institute
16722622 24 Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.EBI Wyeth Research
16274990 21 Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.EBI Wyeth Research
16190750 7 Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.EBI Schering-Plough Research Institute
16112859 6 Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.EBI Schering-Plough Research Institute
15982872 24 Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.EBI Pharmaceutical Research Institute
15588076 6 The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.EBI MRL Rome
15341970 59 P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors.EBI Lilly Research Laboratory
15261297 18 P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors.EBI Lilly Research Laboratory
15115392 52 Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.EBI Schering-Plough Research Institute
15050632 17 Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants.EBI Vertex Pharmaceuticals Inc.
15006379 44 Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.EBI Vertex Pharmaceuticals Inc.
14695826 13 NMR structural characterization of peptide inhibitors bound to the Hepatitis C virus NS3 protease: design of a new P2 substituent.EBI Boehringer Ingelheim (Canada) Ltd.
14611859 3 Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease.EBI Schering-Plough Research Institute
14592508 23 Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants.EBI Vertex Pharmaceuticals Inc.
12873506 8 Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures.EBI MRL Rome
12643933 27 Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.EBI Bristol-Myers Squibb
12617891 37 Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12540231 39 Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.EBI MRL Rome
12419361 23 Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.EBI GlaxoSmithKline Medicines Research Centre
12392743 17 Capped dipeptide alpha-ketoacid inhibitors of the HCV NS3 protease.EBI IRBM, MRL Rome
12372533 69 P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12372517 92 Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.EBI Celera
11909704 43 Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease.EBI Schering-Plough Research Institute
11844706 30 Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.EBI IRBM, MRL Rome
11844705 13 A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.EBI IRBM, MRL Rome
11844690 8 Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase.EBI Roche Discovery Welwyn
11527730 27 Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
11212109 14 The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.EBI Roche Discover Welwyn
11206478 18 Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.EBI Institute of Molecular and Cell Biology
10782670 11 Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors.EBI DuPont Pharmaceuticals Company
9873610 48 Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.EBI Boehringer Ingelheim (Canada) Ltd
9171866 12 Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.EBI Merck Research Laboratories
23023261 6 Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.BDB Astex Pharmaceuticals