BindingDB logo
myBDB logout

22 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
18053726 364 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI Johnson& Johnson Pharmaceutical Research& Development
17665896 30 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.EBI Lek Pharmaceuticals d.d.
9767634 15 Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.EBI F. Hoffmann-La Roche Ltd.
8809160 132 Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.EBI F. Hoffmann-LaRoche Ltd
15026061 1 The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.EBI University of Huddersfield
11012024 44 The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.EBI The R. W. Johnson Pharmaceutical Research Institute
 51 The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporinsEBI TBA
21664132 47 Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.EBI Merck& Co.
21392987 25 Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.EBI Anacor Pharmaceuticals, Inc.
20921316 10 Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.EBI Novexel SA
20299220 4 4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.EBI Merck& Co.
 10 Synthesis and biological activity of novel penem sulfoxides and sulfonesEBI TBA
 2 Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanateEBI TBA
16854068 59 Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.EBI Wyeth Research
15588091 25 Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.EBI Wyeth Research
12801220 16 Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.EBI Wyeth Research
12039585 52 Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.EBI Southern Methodist University
10890171 6 Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.EBI University of Munich
7699694 66 Synthesis and biological activity of 7-alkylidenecephems.EBI Southern Methodist University
3039137 20 Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.EBI TBA