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23 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
14643353 2 Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams.EBI The University of Huddersfield
18053726 364 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI Johnson& Johnson Pharmaceutical Research& Development
17665896 30 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.EBI Lek Pharmaceuticals d.d.
9767634 15 Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.EBI F. Hoffmann-La Roche Ltd.
8809160 132 Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.EBI F. Hoffmann-LaRoche Ltd
15026061 1 The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.EBI University of Huddersfield
11012024 44 The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.EBI The R. W. Johnson Pharmaceutical Research Institute
 51 The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporinsEBI TBA
21664132 47 Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.EBI Merck& Co.
21392987 25 Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.EBI Anacor Pharmaceuticals, Inc.
20921316 10 Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.EBI Novexel SA
20299220 4 4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.EBI Merck& Co.
 10 Synthesis and biological activity of novel penem sulfoxides and sulfonesEBI TBA
 2 Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanateEBI TBA
16854068 59 Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.EBI Wyeth Research
15588091 25 Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.EBI Wyeth Research
12801220 16 Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.EBI Wyeth Research
12039585 52 Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.EBI Southern Methodist University
10890171 6 Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.EBI University of Munich
7699694 66 Synthesis and biological activity of 7-alkylidenecephems.EBI Southern Methodist University
3039137 20 Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.EBI TBA