BindingDB logo
myBDB logout

46 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27131990 59 Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.EBI Vanderbilt University Medical Center
26814576 146 New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.EBI University of Copenhagen
26231155 53 Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.EBI Massachusetts General Hospital
25958247 22 Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.EBI Univ. Rouen
25330258 18 Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).EBI Massachusetts General Hospital
24914612 36 Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).EBI Vanderbilt University Medical Center
24735492 98 Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.EBI Sanford-Burnham Medical Research Institute
23009245 53 Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.EBI Sanford-Burnham Medical Research Institute
22750138 8 ¿-amino-ß-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.EBI INSA de Rouen and Universit£ de Rouen
21247167 57 Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.EBI Vanderbilt University Medical Center
20218620 81 A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.EBI Universite Paris Descartes
18338843 57 Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.EBI Universit£ degli Studi di Milano
17350267 48 Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.EBI Universit£ di Perugia
16213710 32 Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.EBI Universit£ di Perugia
15801843 16 Virtual screening workflow development guided by the"receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.EBI Universit£ Ren£ Descartes-Paris V
9357538 38 (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.EBI Royal Danish School of Pharmacy
7738999 88 Metabotropic glutamate receptors: novel targets for drug development.EBI CNS Research
22030026 13 Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.EBI Vanderbilt University Medical Center
21966889 61 Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinEBI Vanderbilt University Medical Center
20638279 46 An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.EBI Evotec (UK) Ltd
19469556 47 Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).EBI Vanderbilt University Medical Center
 10 Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)EBI TBA
17722902 16 L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.EBI Université Paris Descartes
17376693 36 Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.EBI The Danish University of Pharmaceutical Sciences
16828551 12 Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.EBI Faust Pharmaceuticals
16190758 30 Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.EBI Università degli Studi di Milano
15317467 105 Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.EBI Taisho Pharmaceutical Co., Ltd
14711315 72 (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.EBI Eli Lilly and Company
14643338 124 Binding of beta-carbolines at 5-HT(2) serotonin receptors.EBI Virginia Commonwealth University
12825948 13 Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.EBI Università degli Studi di Milano
12213064 33 Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.EBI The Royal Danish School of Pharmacy
11831912 43 Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.EBI The Royal Danish School of Pharmacy
10866390 7 (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.EBI Novartis Pharma AG
31537424 24 Discovery of a novel 3,4-dimethylcinnoline carboxamide MEBI Vanderbilt University
9871596 4 alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.EBI Georgetown University Medical Center
30350962 102 Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGluEBI Vanderbilt University School of Medicine
30247901 143 Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGluEBI Vanderbilt University
29397723 267 Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.EBI University of Paris
28902994 55 Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.EBI Prexton Therapeutics
26010139 34 Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety.BDB Tehran University of Medical Sciences