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15 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
24799086 74 Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.EBI Pfizer Inc
20829430 218 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.EBI Amgen Inc
27031670 16 Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.EBI Astex Pharmaceuticals
26502061 6 Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials.EBI Universit£ di Siena
21965623 170 In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.EBI AstraZeneca
25310383 50 Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.EBI Novartis Institutes for BioMedical Research
24900633 11 Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.EBI Amgen Inc
12739759 25 Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.EBI Schering-Plough Research Institute
12404239 6 The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.EBI King's College Hospital
30034601 70 Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.EBI Merck & Co.
23956101 2441 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.EBI Amgen Inc
22961681 621 Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.EBI AstraZeneca