BindingDB logo
myBDB logout

46 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28174065 7 Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5a-reductase 2 and with cytotoxic activity in cancer cells.EBI Universidad Nacional Aut£noma de M£xico
26780831 8 Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5a-reductase inhibitors.EBI University Institute of Pharmaceutical Sciences
26631442 6 Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5a-reductase and on cancer cell line SK-LU-1.EBI Universidad Nacional Aut£noma de M£xico
25261928 17 Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3.EBI National University of Mexico
7837223 33 Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase.EBI SmithKline Beecham Pharmaceuticals Ltd
2308144 16 Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors.EBI Smith Kline & French Laboratories
 17 A non-steroidal diene acid inhibitor of human type 2 stereoid 5-reductaseEBI TBA
 19 Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5-reductasesEBI TBA
22776417 7 Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5a-reductase inhibitors: a legitimate approach.EBI Panjab University
15828836 13 Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.EBI University of Maryland
12139451 41 Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.EBI Saarland University
11063622 60 Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.EBI University of the Saarland
11020287 32 Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1.EBI Universit£ di Firenze
9135028 114 Pharmacological options in the treatment of benign prostatic hyperplasia.EBI Pfizer Inc
9089333 37 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2.EBI Universit£ di Firenze
7739004 12 Synthesis and in vitro evaluation of 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17 beta-carboxamides as 5 alpha-reductase inhibitors and antiandrogens.EBI CHUL Research Center
7707319 81 Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor.EBI CHUL Research Center
7650670 67 4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.EBI Merck Research Laboratories
7629802 48 Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.EBI Glaxo Inc. Research Institute
7966146 53 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.EBI Merck Research Laboratories
8057283 126 6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.EBI Glaxo Inc. Research Institute
8381185 24 Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase.EBI Eli Lilly and Company
11425544 14 Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors.EBI Aventis
9873639 12 Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.EBI Universit£ di Firenze
21094046 4 Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor.EBI College of Chemical and Environmental Engineering
 3 The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductaseEBI TBA
 33 A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozymeEBI TBA
 8 Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitorsEBI TBA
 5 Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity.EBI TBA
17490876 2 Evaluation of 4'-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5alpha-reductase.EBI University of Canterbury
16420060 12 Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.EBI Saarland University
15582428 47 Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5alpha-reductases 1 and 2.EBI Polo Scientifico Università di Firenze
15214782 36 Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1.EBI University of Florence
11087568 55 Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).EBI University of the Saarland
10987415 18 Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase.EBI University of Canterbury
10714498 13 Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1.EBI Università di Firenze
10386944 7 N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity.EBI Universität des Saarlandes
9871692 25 Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions.EBI Eli Lilly and Company
9871560 17 Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.EBI Sankyo Co., Ltd
8277514 46 6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.EBI Glaxo Inc. Research Institute
2308145 48 Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids.EBI Smith Kline & French Laboratories
28757062 6 Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5?-androst-17?-amide derivatives as dual 5?-reductase inhibitors and androgen receptor antagonists.EBI China Pharmaceutical University