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21 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28324649 99 Sulfonamides as Selective NaEBI Amgen Inc.
28287723 73 Sulfonamides as Selective NaEBI Amgen Inc.
2579237 115 [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.EBI TBA
27994738 50 Sulfonamides as Selective NaEBI Amgen, Inc.
27038498 33 Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.EBI Gilead Sciences Inc.
26985315 49 Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.EBI Xenon Pharmaceuticals, Inc.
26358159 114 Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.EBI Daiichi Sankyo Co., Ltd
25927480 36 Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.EBI Merck Research Laboratories
26101568 51 Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.EBI Pfizer Inc.
21300721 90 Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.EBI University of Oxford
24601592 48 Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.EBI University College London
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc.
16134928 34 Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI The Scripps Research Institute
11229757 5 Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.EBI Cambridge NeuroScience, Inc.
 15 Batrachotoxin binding site antagonistsEBI TBA
3016269 31 Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.EBI TBA
26833890 18 Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB Yogi Vemana University
26469307 7 Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.BDB University of Leipzig
7932531 55 Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity.BDB SANDOZ Forschungsinstitut Ges.m.b.H.