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23 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
23562062 4 Arylsulfonamide pyrimidines as VLA-4 antagonists.EBI Elan Pharmaceuticals, Inc.
17125246 11 Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.EBI Cerep
24900456 46 Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.EBI TBA
19879752 12 Identification of novel agonists of the integrin CD11b/CD18.EBI Department of Medicine and University of Miami
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
12139455 78 Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.EBI Genentech Inc.
12643901 42 N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.EBI Genentech
21109434 40 Structure-activity relationship (SAR) of thea-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.EBI Sunesis Pharmaceuticals, Inc
20655213 31 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.EBI Sunesis Pharmaceuticals, Inc.
15686933 12 De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.EBI Cerep
15481974 43 Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.EBI Boehringer Ingelheim Pharmaceuticals
15109637 30 Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.EBI Novartis Institutes for Biomedical Research
15080978 66 N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.EBI Genentech
12565959 9 1,4-Diazepane-2-ones as novel inhibitors of LFA-1.EBI Novartis Institute for Biomedical Research
11728185 55 Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.EBI Abbott Laboratories
11520199 25 Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.EBI Abbott Laboratories
11327603 31 Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.EBI Abbott Laboratories
11312920 23 Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.EBI Abbott Laboratories
11052808 75 Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.EBI Abbott Laboratories
10853677 34 Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists.EBI Celltech Chiroscience
10072689 39 Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.EBI Biogen Inc.
9016328 19 Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.EBI DuPont Merck Pharmaceutical Company
7707308 3 Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.EBI R.W. Johnson Pharmaceutical Research Institute