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17 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
17125246 11 Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.EBI Cerep
24900456 46 Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.EBI TBA
12643901 42 N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.EBI Genentech
20655213 31 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.EBI Sunesis Pharmaceuticals, Inc.
15686945 19 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.EBI Novartis Institutes for BioMedical Research
15582439 84 Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding.EBI Abbott Laboratories
15109637 30 Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.EBI Novartis Institutes for Biomedical Research
15080978 66 N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.EBI Genentech
12565959 9 1,4-Diazepane-2-ones as novel inhibitors of LFA-1.EBI Novartis Institute for Biomedical Research
11585452 291 Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.EBI Abbott Laboratories
11520199 25 Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.EBI Abbott Laboratories
11327603 31 Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.EBI Abbott Laboratories
11300880 168 Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.EBI Abbott Laboratories
11052808 75 Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.EBI Abbott Laboratories
10853677 34 Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists.EBI Celltech Chiroscience
10072689 39 Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.EBI Biogen Inc.
8145218 8 3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.EBI Warner-Lambert Company