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172 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
10915041 2 Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase.EBI Department of Chemistry, The University of Montana, Missoula 59812, USA.
27908752 55 N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.EBI University of Ljubljana
27448914 30 Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction.EBI University Institute of Pharmaceutical Sciences
27598521 22 Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.EBI Ume£ University
27552582 42 Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.EBI East China University of Science and Technology
27392529 32 Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.EBI Universidade Federal do Rio Grande do Sul
26947959 35 Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.EBI University of Pardubice
26632651 70 Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.EBI China Pharmaceutical University
26363872 19 Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors.EBI Alzahra University
26260334 28 Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity.EBI Medical University of Sofia
25678013 63 Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25082512 38 Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.EBI Zhejiang University
26116179 5 Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.EBI University of Ljubljana
25778991 116 Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25614117 37 Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.EBI Sichuan University
25017625 45 Synthesis and cholinesterase inhibition of cativic acid derivatives.EBI Universidad Nacional del Sur
25468034 33 Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.EBI Kyung Hee University
25226236 19 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.EBI University of Ljubljana
25205193 10 Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B.EBI Hunan University
24835788 28 Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.EBI Universidad Nacional del Sur
24731278 22 Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.EBI Bar Ilan University
24485122 9 Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.EBI Kyung Hee University
24148993 4 Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.EBI Punjabi University
23984975 29 Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.EBI Ume£ University
23941108 1 Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.EBI Fudan University
23422935 29 Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.EBI Universidade Federal do Rio Grande do Sul
23380475 7 Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.EBI Hainan University
23273608 20 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.EBI The Hong Kong University of Science and Technology
23199476 36 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
15317459 46 Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.EBI Universitat de Barcelona
18976927 83 Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.EBI Universit£ degli Studi di Parma
 1 A New Diterpene from a Soft Coral, Sinularia dissectaEBI TBA
8558505 77 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.EBI University of Missouri-St. Louis
3351860 56 Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.EBI Dynamac Corporation
3336013 52 Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase.EBI University of Pittsburgh
3965704 22 Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase.EBI TBA
23151013 56 Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.EBI Bar Ilan University
23033965 37 Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.EBI Istituto Italiano di Tecnologia
23026084 17 Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.EBI CSIR Central Drug Research Institute
22172310 47 Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.EBI Punjabi University
22831800 32 Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities.EBI Meiji Pharmaceutical University
22243648 112 New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.EBI Instituto de Qu£mica M£dica
22185619 50 Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.EBI Universitat de Barcelona
20575555 45 Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.EBI Universidad Autonoma de Madrid
20176490 8 Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.EBI Institute of Plant Biochemistry
18538575 3 Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp.EBI Mahidol University
18517184 47 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
18479118 113 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
15568781 2 Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors.EBI Instituto de Qu£mica da Universidade Estadual Paulista
18333606 29 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.EBI Fudan University
17854153 2 Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus.EBI Institute of Plant Biochemistry
17904850 3 Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.EBI Hoshi University
17944454 34 First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.EBI University of Bonn
17888667 33 Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.EBI University of Mysore
17154513 56 Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.EBI Universitat de Barcelona
15993600 54 Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
15139762 133 Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.EBI University of Hamburg
12502352 28 Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.EBI Universit£ di Siena
11831902 12 Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.EBI Institute of Research
11741490 18 Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.EBI Universitat de Barcelona
11101357 84 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
10052979 45 Aminopyridazines as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
10464010 40 Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
8978837 60 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.EBI University of North Carolina
8893840 12 The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.EBI Eisai Co., Ltd.
7490731 45 Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.EBI Eisai Company, Ltd.
7658452 52 Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals, Inc
1552502 74 Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.EBI University of South Carolina
2033583 10 Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.EBI University of Iowa
1766006 7 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.EBI Mayo Clinic Jacksonville
2913310 68 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.EBI SRI International
12031333 5 Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.EBI Georgetown University Medical Center
11551765 7 Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.EBI Universit£t Wien
11078202 4 Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.EBI Georgetown University Medical Center
10476864 22 Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.EBI Hong Kong University of Science and Technology
9873409 2 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.EBI Chinese Academy of Sciences
 32 Acetylcholinesterase inhibition by fused dihydroquinazoline compoundsEBI TBA
 9 Synthesis of ()-10,10-dimethylhuperzine A a huperzine analogue possessing a slower enzyme off-rateEBI TBA
21438612 4 Amidine-oximes: reactivators for organophosphate exposure.EBI Human BioMolecular Research Institute
22257528 5 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.EBI Punjabi University
21420206 38 N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.EBI Instituto de Qu£mica M£dica
22019465 28 Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.EBI Zhejiang University
21459491 96 Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.EBI Universit£ degli Studi di Genova
21417225 116 Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.EBI Universidad de Granada
21163662 39 Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
20926162 14 Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.EBI Instituto de Qu£mica M£dica
18438404 13 Activation of the endocannabinoid system by organophosphorus nerve agents.EBI University of California
20545360 38 Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.EBI Instituto de Quimica Medica
20144867 32 Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.EBI Zhejiang University
20137941 44 Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.EBI Kyoto University
20137934 38 Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.EBI Kyoto University
19856923 40 Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.EBI Instituto de Quimica Medica (CSIC)
19726199 30 Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.EBI The Chinese Academy of Sciences
19692250 52 Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.EBI Zhejiang University
19954865 10 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.EBI Universidade Federal do Rio Grande do Sul
19493592 30 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.EBI University of Mysore
 18 Acetylcholinesterase inhibition by tacrine analoguesEBI TBA
 11 Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitorEBI TBA
 22 Synthesis, insecticidal and anti-acetylcholinesterase activity of a new class of heterocyclic methanesulfonatesEBI TBA
 7 Synthesis and in vitro gastrointestinal motility enhancing activity of 3-aryl-2-imidazolidinylidene propanedinitrile derivativesEBI TBA
 26 Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrineEBI TBA
 5 m-Alkyl, α,α,α-trifluoroacetophenones: A new class of potent transition state analog inhibitors of acetylcholinesteraseEBI TBA
 27 Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compoundsEBI TBA
 12 Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrineEBI TBA
 15 Synthesis and biological activity of galanthamine derivatives as acetylcholinesterase (AChE) inhibitorsEBI TBA
19485411 2 Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy.EBI Institute of Science
19162488 57 Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.EBI Chinese Academy of Sciences
18662884 56 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.EBI Zhejiang University
18585045 22 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.EBI Università di Bari
18550228 40 Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
18485717 3 Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.EBI Hoshi University
18436348 68 Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.EBI Zhejiang University
17624631 9 Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Università di Bologna
17317172 9 Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.EBI Sun Yat-sen University
17188496 3 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.EBI Hoshi University
17126020 58 Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.EBI Chinese Academy of Sciences
16942022 20 Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.EBI Institute of Science
16735118 23 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.EBI University of Mysore
15664805 15 Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.EBI Chinese Academy of Sciences
14584959 55 Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.EBI University of Innsbruck
12729674 6 Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.EBI Instituto Politécnico Nacional
12646025 12 Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.EBI Universidade Federal do Rio de Janeiro
10612585 4 Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.EBI Institute of Materia Medica
9871563 31 Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.EBI Istituto di Strutturistica Chimica G. Giacomello
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
9301662 50 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.EBI University of North Texas
8709135 20 Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.EBI Warner-Lambert Company
8558530 4 Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8126709 49 Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.EBI Centre de Recherche Pierre Fabre Médicament
8057278 43 Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.EBI Takeda Chemical Industries, Ltd.
8027982 19 Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.EBI Pfizer Inc.
7932538 54 Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.EBI Takeda Chemical Industries, Ltd.
7636858 25 Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.EBI Centre de Recherche Pierre Fabre
6827532 2 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.EBI TBA
3385720 2 (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.EBI Hoechst-Roussel Pharmaceuticals, Inc.
1469686 53 Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.EBI Eisai Co., Ltd.
19842944 6 Inactivation of acetylcholinesterase by various fluorophores.BDB The University of Montana
27441832 43 Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases.BDB Hazara University
25941042 28 Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.BDB Sichuan University
25965977 15 Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers.BDB Panjab University
24040835 14 The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.BDB Mayo Clinic College of Medicine
18825527 22 Acetylcholinesterase/butyrylcholinesterase inhibition activity of some new carbacylamidophosphate derivatives.BDB Tarbiat Modares University
18821258 11 Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors.BDB Centre d'Etudes et de Recherche sur le Médicament de Normandie
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB Pudue Pharma Discovery Research
17252943 10 New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids.BDB University of Karachi
15895683 14 Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.BDB Quaid-i-Azam University
20455574 9 Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy.BDB The Weizmann Institute of Science
19663388 40 Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.BDB Universitat de Barcelona
17902635 86 New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.BDB CNRS
17149883 62 Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.BDB Rheinische Friedrich-Wilhelms-Universitat Bonn
16913695 12 Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).BDB Istituto di Cristallografia
15689148 19 Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.BDB Shanghai Institute of Materia Medica
12196020 3 X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.BDB Weizmann Institute of Science
11888271 2 Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.BDB Weizmann Institute of Science
11563919 20 A structure-based design approach to the development of novel, reversible AChE inhibitors.BDB Syngenta
10218828 16 Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.BDB Hong Kong University of Science and Technology
8798583 19 Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.BDB Mayo Foundation for Medical Education and Research
10632067 50 Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.BDB Hong Kong University of Science and Technology
12517147 6 Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.BDB Weizmann Institute of Science
9839013 32 Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.BDB CNRS
15563167 10 The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.BDB Weizmann Institute of Science
10514292 42 Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.BDB Hong Kong University of Science and Technology
2362265 40 Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.BDB Tsukuba Research Laboratories
2754707 39 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.BDB Hoechst-Roussel Pharmaceuticals, Inc.
16230018 28 Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.BDB Neuropharma
12014965 38 Homodimeric tacrine congeners as acetylcholinesterase inhibitors.BDB National Defense Medical Center
16279781 50 Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.BDB Neuropharma
16420031 46 Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.BDB Instituto de Quimica Medica (CSIC)
15324879 12 Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.BDB Shanghai Institute of Materia Medica