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22 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26900660 35 Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2.EBI Dalian Institute of Chemical Physics
23386702 10 Reversible inhibition of human carboxylesterases by acyl glucuronides.EBI Eisai Inc.
23286284 50 Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
19062296 63 Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.EBI Kyoto University
19534556 57 Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.EBI St. Jude Children's Research Hospital
18630870 236 Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.EBI Institute for Chemical Biology
18247553 174 Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
18023188 86 Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).EBI University of California
17279740 191 Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.EBI The Scripps Research Institute
21733699 121 Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.EBI St. Jude Children's Research Hospital
21105730 30 Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.EBI St. Jude Children's Research Hospital
18639454 55 Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.EBI The Scripps Research Institute
17399985 136 Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.EBI St. Jude Children's Research Hospital
16107154 41 Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.EBI St. Jude Children's Research Hospital
15771430 129 Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.EBI The Scripps Research Institute
15713400 99 Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.EBI The Scripps Research Institute
27391855 24 Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.BDB Pfizer Inc.
25146964 12 Synthesis, biological evaluation, and molecular docking studies of xanthone sulfonamides as ACAT inhibitors.BDB Second Military Medical University
12725862 9 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.BDB University of North Carolina at Chapel Hill
17941623 72 Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.BDB St. Jude Research Hospital
17378546 325 Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.BDB St. Jude Research Hospital
15828829 300 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.BDB University of Mississippi