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179 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27770735 6 Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers.EBI King Saud University
27979595 73 Imidazopyridyl compounds as aldosterone synthase inhibitors.EBI Merck USA
27789139 69 Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.EBI Temple University School of Pharmacy
27647367 36 A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptorsa and฿.EBI Purdue University
27155469 8 Recent developments of C-4 substituted coumarin derivatives as anticancer agents.EBI Central University of Punjab
26689671 21 Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.EBI State University of New York Upstate Medical University
27161804 28 Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.EBI University of Chieti 'G. d'Annunzio'
27160054 4 Exploring new chemical functionalities to improve aromatase inhibition of steroids.EBI University of Coimbra
27155563 5 Isocoumarins, miraculous natural products blessed with diverse pharmacological activities.EBI Quaid-I-Azam University
26938274 52 Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.EBI University of Bologna
26469743 153 Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.EBI The M. S. University of Baroda
26301554 49 Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer.EBI American University of Ras Al Khaimah
26288685 59 Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
25992880 90 Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.EBI University of Bath
25934226 24 Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors.EBI Srinakharinwirot University
26005536 92 Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.EBI Merck Research Laboratories
25874338 90 Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11฿-Hydroxylase.EBI Saarland University
25751283 79 Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.EBI Purdue University
25711516 118 Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25277066 10 Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.EBI University of Coimbra
25528333 32 Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.EBI Saarland University
25461329 9 Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.EBI Dongguk University-Seoul
24992702 2 Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.EBI University of Hawaii at Manoa
24422519 31 Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
25462231 85 Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11฿-hydroxylase.EBI Universit£ degli Studi di Bari"Aldo Moro"
25155384 16 Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1).EBI McMaster University
722711 5 Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis.EBI TBA
24630560 2 Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component.EBI Hanyang University
24345481 14 Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors.EBI Northern Kentucky University
24331756 9 Pyrrolizines: Promising scaffolds for anticancer drugs.EBI Beni-Suef University
24900631 50 Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.EBI Novartis Institutes for BioMedical Research
24113062 17 Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).EBI McMaster University
24025069 36 Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.EBI University of Padova
24074257 6 Synthesis and bioconversions of formestane.EBI The University of Tampa
23994869 6 Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.EBI Universit£ di Bologna
23859149 76 Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
23731360 12 Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.EBI Purdue University
23403081 20 Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.EBI Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)
23363058 68 Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.EBI University of Bologna
23281812 95 Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
3361583 5 Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity.EBI Institute of Cancer Research
3959033 7 Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors.EBI TBA
3968684 2 Analogues of aminoglutethimide: selective inhibition of aromatase.EBI TBA
23142320 14 Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).EBI Purdue University
22951074 11 Novel aromatase inhibitors by structure-guided design.EBI State University of New York Upstate Medical University
22861193 60 Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
22788843 46 Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.EBI Saarland University and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
22475216 13 New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.EBI University of Coimbra
22444875 25 Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.EBI Northern Kentucky University
21174408 13 Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.EBI Chulabhorn Institute
20550118 69 Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.EBI Saarland University
20558073 28 Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.EBI Purdue University
20568782 16 Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.EBI University of Bologna
20413308 53 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).EBI Johns Hopkins University
20148564 60 Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.EBI University of Bath
18778944 8 Screening of herbal constituents for aromatase inhibitory activity.EBI King's College London
18462007 7 Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara.EBI Universidade Federal de Minas Gerais
18357974 42 "Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.EBI Novartis Institutes for BioMedical Research
18042388 13 New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.EBI UPRES EA 4021 Biomol�cules et Th�rapies anti-tumorales
18271519 65 Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.EBI The Ohio State University
17511439 24 Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.EBI Purdue University
16190763 9 Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.EBI University of Oporto
12930139 22 Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
1578485 19 Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors.EBI Centre de Recherches Roussel-UCLAF
1875347 23 Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors.EBI Tohoku College of Pharmacy
1825337 22 Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.EBI CIBA-GEIGY Corporation
2231592 36 Mechanism and inhibition of cytochrome P-450 aromatase.EBI Johns Hopkins University School of Medicine
2918514 17 Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione.EBI Washington University School of Medicine
2677377 3 Is there a case for P-450 inhibitors in cancer treatment?EBI Janssen Research Foundation
2909733 6 Interactions of thiol-containing androgens with human placental aromatase.EBI University of Washington
6827528 1 Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage.EBI TBA
22386564 43 Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.EBI Purdue University
22335894 10 New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series.EBI Novartis Institutes for BioMedical Research
22115839 42 Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets.EBI Purdue University
22079757 13 Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).EBI McMaster University
21978950 28 Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.EBI University of Hawai'i at Hilo
21937153 46 Recent progress in synthesis and bioactivity studies of indolizines.EBI University of Botswana
21703734 68 Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors.EBI Universit£ de Moncton
21604760 31 Structure-based design of potent aromatase inhibitors by high-throughput docking.EBI Universita` di Modena e Reggio Emilia
21497425 13 Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors.EBI UPRES EA 4021 Biomol�cules et Th�rapies anti-tumorales
21384875 67 Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.EBI Saarland University
21341743 42 Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase.EBI Universita` degli Studi di Bari Aldo Moro
21261296 6 Bioactive compounds from the fern Lepisorus contortus.EBI Yunnan Normal University
24900302 27 Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory ActivityEBI TBA
21129965 18 N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).EBI Saarland University& Helmholtz Institute for Pharmaceutical Research Saarland
20926163 32 Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors.EBI Tianjin University of Science and Technology
20638757 89 Exploring benzcyclo derivatives as potent aromatase inhibitors using ligand-based modeling studies.EBI University of Calcutta
20684610 73 Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.EBI Saarland University
19824618 1 Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.EBI Institute and the Center for Environmental Health
19500885 10 An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.EBI Universidade de Coimbra
18939864 3 Monodictyochromes A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis.EBI University of Bonn
19608417 26 Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).EBI University of the West of Scotland
 8 The synthesis of N-aryl androsterone pyrazoles as aromatase inhibitorsEBI TBA
 4 Synthesis of 7α-substituted androstenediones by a 1,4-conjugate addition approachEBI TBA
 1 Molecular modelling of inhibitors of aromatase — a novel approachEBI TBA
19072235 98 Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.EBI Universidade de Coimbra
19049427 98 In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.EBI Saarland University
18782670 39 CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors.EBI Università di Salerno
18763754 57 Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.EBI Saarland University
18672861 91 Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.EBI Saarland University
18640836 9 Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors.EBI Université de Nantes
18558747 5 Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.EBI University of Illinois at Chicago
18192087 9 Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.EBI Universidade Federal do Rio Grande do Sul (UFRGS)
16643058 7 Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.EBI University of Illinois at Chicago
11678652 16 Aromatase inhibitors from Broussonetia papyrifera.EBI University of Illinois at Chicago
17585752 10 Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.EBI TBA
17315855 7 Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.EBI The Ohio State University
17291041 7 Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.EBI University of Bonn
16854084 19 Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.EBI University of Bologna
16480277 18 Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.EBI The Ohio State University
16380254 9 Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.EBI Nantes University
15380230 5 Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors.EBI UPRES EA 1085 Biomolécules et Cibles Cellulaires Tumorales
14584934 15 Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12699753 12 Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.EBI UFR des Sciences Pharmaceutiques
12270163 5 Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.EBI UPRES EA 1085
11909717 7 New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.EBI UPRES EA 1085
11262078 19 A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.EBI University of Bologna
11087568 55 Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).EBI University of the Saarland
10450990 8 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.EBI Cardiff University
10091679 9 New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles.EBI Nantes
9871704 8 Design and synthesis of a new type of non steroidal human aromatase inhibitors.EBI Centre d'Etudes et de Recherche sur le Médicament de Normandie
9379446 10 6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase.EBI University of Minnesota
9357513 15 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.EBI SmithKline Beecham Pharmaceuticals
8765515 37 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.EBI Cancer Research Campaign Centre for Cancer Therapeutics
8632407 43 Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.EBI Universität de Saarlandes
8496907 8 Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.EBI CIBA-GEIGY Ltd
8340925 18 Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.EBI Syntex Discovery Research
8176709 32 6-Alkyl- and 6-arylandrost-4-ene-3,17-diones as aromatase inhibitors. Synthesis and structure-activity relationships.EBI Tohoku College of Pharmacy
8176705 25 Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins.EBI Universität des Saarlandes
8035427 51 Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.EBI Tohoku College of Pharmacy
7783141 28 Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.EBI Universität des Saarlandes
7636845 8 Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase.EBI Ohio State University
7608911 35 Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.EBI Institute of Cancer Research
7562951 4 Probing the hydrophobic pocket of the active site of aromatase with 4-phenoxy-7 alpha-(phenylthio)-4-androstene-3,17-dione.EBI University of Minnesota
7473546 61 Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis.EBI CRC Laboratory
3754286 17 Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.EBI TBA
3735304 14 Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones.EBI TBA
3625703 38 Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.EBI TBA
2391706 22 Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.EBI Institute of Cancer Research
2296006 7 Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors.EBI Ohio State University
2231604 69 Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid.EBI Institute of Cancer Research
2033599 8 Novel time-dependent inhibitors of human placental aromatase.EBI Marion Merrell Dow Research Institute
2016709 8 Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids.EBI Johns Hopkins University School of Medicine
2016706 29 Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.EBI CIBA-GEIGY AG.
1895288 23 New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.EBI Universität des Saarlandes
1613747 10 Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones.EBI Universität des Saarlandes
1495014 36 Stereoisomers of ketoconazole: preparation and biological activity.EBI Syntex Research
1433182 11 Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives.EBI Institute of Cancer Research
27565954 11 Synthesis, biological evaluation, and molecular docking studies of new pyrazol-3-one derivatives with aromatase inhibition activities.BDB Yueyang Vocational Technical College
22726671 8 Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents.BDB Central Institute of Medicinal and Aromatic Plants
15968818 10 Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase.BDB Cardiff University
11916147 11 Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis.BDB Cardiff University
19265439 43 Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.BDB Purdue University
18307303 75 Discovery of selective aminothiazole aurora kinase inhibitors.BDB Novartis
17580845 45 Dual aromatase-steroid sulfatase inhibitors.BDB University of Bath
18590272 33 Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.BDB University of Bath
18260617 131 3-Amino-benzo[d]isoxazoles as Novel Multitargeted Inhibitors of Receptor Tyrosine Kinases.BDB Abbott Laboratories
15466206 10 BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.BDB Bayer Pharmaceuticals Corporation
16949284 34 The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.BDB Johnson & Johnson Pharmaceutical
14981513 6 VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.BDB Vertex Pharmaceuticals (Europe) Limited
8576919 30 Structure-activity relationships of a new family of steroidal aromatase inhibitors. 1. Synthesis and evaluation of a series of analogs related to 19-[(methylthio)methyl]androstenedione (RU54115).BDB Centre de Recherche de Roussel Uclaf
10794700 40 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.BDB Universitat des Saarlandes
12852749 11 First dual aromatase-steroid sulfatase inhibitors.BDB University of Bath
16451067 16 Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.BDB Cardiff University
11708928 17 Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase.BDB Tohoku Pharmaceutical University
8667367 28 Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors.BDB Tohoku College of Pharmacy
8676338 16 Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.BDB Tohoku College of Pharmacy
16279787 14 Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.BDB University of Bologna
16125392 15 Lead optimization of 7-benzyloxy 2-(4'-pyridylmethyl)thio isoflavone aromatase inhibitors.BDB Ohio State University
15911319 10 Synthesis and characterization of azole isoflavone inhibitors of aromatase.BDB Ohio State University
15615528 50 Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.BDB University of Bari
15267241 17 Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.BDB Ohio State University
15202489 50 Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites and evaluation of their activity by a non cellular assay using recombinant human enzyme.BDB Saarland University
16220979 64 Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.BDB Saarland University
16570918 49 Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.BDB Saarland University
15771425 65 Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.BDB Saarland University
16162008 146 Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.BDB Abbott Laboratories
15743198 134 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.BDB Saarland University