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77 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
533888 1 Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation.EBI TBA
23260349 51 Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.EBI Pfizer Inc
23623673 119 7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors.EBI Dainippon Sumitomo Pharma Co., Ltd
4067988 18 Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2.EBI TBA
 17 Synthesis and pharmacological evaluation of combined thromboxane receptor antagonist/synthase inhibitors: pyridine-containing sulphonamido acidsEBI TBA
 43 Synthesis and pharmacological evaluation of combined Thromboxane receptor antagonists/thromboxane synthase inhibitors: Pyridine-containing amino-prostanoidsEBI TBA
18029174 10 Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.EBI Merck Frosst Centre for Therapeutic Research
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
7658441 89 Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.EBI Biofor Inc.
7932529 37 Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.EBI Eisai Company, Ltd
8021921 28 Dual angiotensin converting enzyme/thromboxane synthase inhibitors.EBI Ciba-Geigy Corporation
8411014 20 Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition.EBI Farmitalia Carlo Erba
1447736 17 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds.EBI Ciba-Geigy Corporation
2299629 24 Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines.EBI Wyeth Research UK
3681898 53 Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones.EBI Medical Research Division of American Cyanamid Company
2879917 29 N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents.EBI TBA
3517332 12 Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.EBI TBA
4038746 74 Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids.EBI TBA
3918169 24 Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.EBI TBA
7199089 25 Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.EBI TBA
7199088 50 Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives.EBI TBA
21295979 91 Trisubstituted ureas as potent and selective mPGES-1 inhibitors.EBI Merck Frosst Center for Therapeutic Research
20144869 90 Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.EBI Pfizer Inc
19748780 70 Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.EBI Merck Frosst Centre for Therapeutic Research
 11 Design of dual-acting thromboxane antagonist-synthase inhibitors by a mutual prodrug approachEBI TBA
 4 Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel.EBI TBA
 9 Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.EBI TBA
 9 Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. IEBI TBA
 16 Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitorEBI TBA
 24 Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluationEBI TBA
 8 Discovery of dual activity molecules with thromboxane antagonist and thromboxane synthase inhibitory activityEBI TBA
 5 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 7. pyridinylalkyl-substituted arylsulfonylamino arylalkanoic acids.EBI TBA
 5 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 6. 4-substituted 3-pyridinylalkanoic acids.EBI TBA
 13 Dual-acting thromboxane receptor antagonist/synthase inhibitors: heterocyclic variationsEBI TBA
18459759 9 Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.EBI Merck Frosst Centre for Therapeutic Research
15953724 38 Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.EBI Merck Frosst Centre for Therapeutic Research
11992782 6 Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).EBI Nikken Chemicals Co., Ltd.
11858999 21 Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).EBI Nikken Chemicals Co., Ltd.
11814792 18 Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs.EBI Nikken Chemicals Co., Ltd.
11327579 3 Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition.EBI Facultés Universitaires N.D. de la Paix
11087568 55 Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).EBI University of the Saarland
10197967 70 Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors.EBI Boehringer Ingelheim Pharma KG
9876106 49 Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.EBI Eli Lilly and Company
9873486 1 Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[[(4-chlorophenyl)sulfonyl]-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists.EBI Pfizer Inc
9873463 39 Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives.EBI Eli Lilly and Company
9871770 16 New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors.EBI Centre de Recherches de Croissy
9341919 29 Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.EBI Pfizer Inc
8831771 64 On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel.EBI University of Innsbruck
8496929 12 Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.EBI Kyowa Hakko Kogyo Co., Ltd
8423593 6 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 5. Synthesis and evaluation of enantiomers of 8-[[(4-chlorophenyl)sulfonyl]amino]-4-(3-pyridinylalkyl)octanoic acid.EBI Ciba-Geigy Corporation
8289199 105 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.EBI Dr. Karl Thomae GmbH
8258828 15 Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones.EBI Chugai Pharmaceutical Company, Ltd.
8246226 89 Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.EBI Ciba-Geigy Corporation
7932586 102 Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids.EBI Pharmacia-Farmitalia Carlo Erba
7861416 90 Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids.EBI Zeneca Pharmaceuticals
7752186 29 A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-thromboxane receptor antagonists and -thromboxane synthase inhibitors.EBI Zeneca Pharmaceuticals
3959030 9 Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides.EBI TBA
3930740 60 Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.EBI TBA
3746813 19 Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids.EBI TBA
3656356 18 Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids.EBI Searle Research and Development
3585902 20 Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors.EBI TBA
3305945 27 Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors.EBI TBA
3091830 41 Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene.EBI TBA
3081722 47 Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.EBI TBA
2970551 1 Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1] hept-2-exo-yl]heptenoic acid.EBI Shionogi & Co., Ltd
2724299 20 Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives.EBI Sankyo Co., Ltd
2704033 13 [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.EBI Syntex Research
2547071 27 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.EBI Roche Research Center
1992126 54 Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.EBI Takeda Chemical Industries, Ltd
1829485 15 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids.EBI Ciba-Geigy Corporation
1447738 26 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs.EBI Ciba-Geigy Corporation
1447737 7 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids.EBI Ciba-Geigy Corporation
1388207 72 Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1.EBI Kyowa Hakko Kogyo Co., Ltd
1311763 14 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.EBI Syntex Research
15798001 56 Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.BDB Kyowa Hakko Kogyo Co., Ltd
15626721 8 In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.BDB University of Li&eagrove;ge
10794700 40 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.BDB Universitat des Saarlandes