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75 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27939174 84 Challenges in the development of an MEBI Vanderbilt University Medical Center
27072910 92 New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center.EBI University of Montpellier
26100441 25 Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model.EBI Asubio Pharma Co., Ltd
25981690 32 2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor.EBI Asubio Pharma Co., Ltd
25435152 58 New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.EBI University of Montpellier
25905598 59 Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.EBI Universit£t Leipzig
25699143 26 Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.EBI Pfizer Inc
25036503 4 Small molecule ghrelin receptor inverse agonists and antagonists.EBI Pfizer Inc
24967667 45 Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.EBI AstraZeneca
25313322 62 Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.EBI Novartis Institutes for BioMedical Research
24900864 21 Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.EBI Pfizer Inc
23953189 53 Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.EBI Pfizer Inc
23816043 2 Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffold.EBI Universit£ degli Studi di Milano
19128969 29 Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.EBI GlaxoSmithKline
15780609 52 Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
21381769 56 Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI Universite£ de Sherbrooke
22920150 35 An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.EBI Universit£t Leipzig
22901671 43 Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists.EBI Sanofi Research
22712585 106 Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.EBI Universit£ de Montr£al
22832315 85 Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.EBI AstraZeneca
22677316 35 Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.EBI Pfizer Inc
22305493 33 Discovery of a new class of ghrelin receptor antagonists.EBI Amgen Inc
19323558 15 Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor.EBI University of Western Ontario
19191554 43 Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.EBI GlaxoSmithKline
18554903 5 (D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.EBI Bristol Myers Squibb
18378446 34 Tetrazole based amides as growth hormone secretagogues.EBI Bristol-Myers Squibb Research and Development
18282707 56 Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
18295486 19 Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.EBI Bristol Myers Squibb
17329109 50 Modeling of human ghrelin receptor (hGHS-R1a) in its close state and validation by molecular docking.EBI Universit£ degli Studi di Milano
17887659 58 Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.EBI Bayer Pharmaceuticals Corporation
16722627 35 Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis.EBI Universit£ di Milano
15780607 13 Structure-activity relationships of the oxindole growth hormone secretagogues.EBI Sumitomo Pharmaceuticals Co., Ltd
12646029 40 New active series of growth hormone secretagogues.EBI University of Montpellier
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI Merck Research Laboratories
11459669 20 Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.EBI Merck Research Laboratories
10636230 12 Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.EBI Merck Research Laboratories
22342626 42 Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity.EBI Prosidion Ltd
21388815 1 Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR).EBI The Johns Hopkins University School of Medicine
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20137933 218 Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.EBI Amgen Inc
19804969 109 The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.EBI GlaxoSmithKline
19767208 33 Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.EBI Merck Research Laboratories
19963374 68 Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent.EBI Pfizer Inc
19006669 82 The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.EBI GlaxoSmithKline
18722770 60 Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).EBI Bristol-Myers Squibb Co.
18417348 82 Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.EBI Neurocrine Biosciences Inc
17371869 24 Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.EBI University of Copenhagen
18193826 45 New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.EBI University of Montpellier
18023181 46 Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: on the significance of the orientation and substitution at position 3.EBI University of Montpellier
17994683 55 Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.EBI Neurocrine Biosciences Inc
17869100 76 Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17822895 110 Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences Inc
17544282 39 Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.EBI Neurocrine Biosciences Inc
17375904 80 Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1.EBI University of Montpellier
16442284 99 Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration.EBI Abbott Laboratories
15686942 59 Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.EBI Abbott Laboratories
15615511 8 Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation.EBI Abbott Laboratories
15380232 52 Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.EBI Abbott Laboratories
15294000 14 Identification of structurally diverse growth hormone secretagogue agonists by virtual screening and structure-activity relationship analysis of 2-formylaminoacetamide derivatives.EBI Institute for Life Science Research
14761190 10 Recognition of privileged structures by G-protein coupled receptors.EBI Novo Nordisk A/S
14698149 14 Parallel solid-phase synthesis of disubstituted (5-biphenyltetrazolyl) hydantoins and thiohydantoins targeting the growth hormone secretagogue receptor.EBI Novo Nordisk A/S
12392732 5 Discovery and biological characterization of capromorelin analogues with extended half-lives.EBI Pfizer Inc
11087562 27 Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.EBI Merck Research Laboratories
9703459 5 Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential.EBI Merck Research Laboratories
8627599 4 Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor.EBI Merck Research Laboratories
18316188 31 Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.EBI GlaxoSmithKline
17942309 18 Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.EBI GlaxoSmithKline
30265805 71 Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases.EBI SIB Swiss Institute of Bioinformatics
29909635 160 Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.EBI AstraZeneca
23839942 19 Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.BDB Université Montpellier 1
17973363 13 Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).BDB Bristol-Myers Squibb Pharmaceutical Research Institute
16610800 36 2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.BDB Abbott Laboratories
16854051 30 Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.BDB Abbott Laboratories
17927165 58 Toward Potent Ghrelin Receptor Ligands Based on Trisubstituted 1,2,4-Triazole Structure. 2. Synthesis and Pharmacological in Vitro and in Vivo Evaluations.BDB CNRS