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166 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28621538 63 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.EBI Novartis Pharma AG
28157311 11 Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.EBI Novartis Institutes for BioMedical Research
27564532 3 Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.EBI Bristol-Myers Squibb Research and Development
26358162 27 Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.EBI Bayer HealthCare AG
25782055 9 Discovery of a Cyclic Boronic Acid▀-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.EBI Rempex Pharmaceuticals, Inc.
25650311 76 Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.EBI Chang Gung University
25408826 8 Neutrophil elastase inhibitors as potential anti-inflammatory therapies.EBI Therachem Research Medilab (India) Pvt. Ltd.
915907 6 Proteinase inhibitors. I. Inhibitors of elastase.EBI TBA
24556381 4 Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase.EBI Universidad de Buenos Aires
24224573 31 Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors.EBI Universidade de Lisboa
24135727 7 Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.EBI Emory University School of Medicine
24102612 105 Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.EBI University of Bari "Aldo Moro"
23844670 52 Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.EBI Universit£ degli Studi di Firenze
23719288 41 Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.EBI Asubio Pharma Co., Ltd
23350733 10 Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.EBI University of Florida
2299617 174 Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase.EBI Syntex Research
4068006 46 Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones.EBI TBA
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
22882079 26 Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.EBI Aarhus University
22595175 18 N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases.EBI University of Lisbon
17535802 91 Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.EBI Merck Research Laboratories
18318470 1 X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.EBI Wichita State University
18078761 2 Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations.EBI Albert-Ludwigs-Universit£t Freiburg
18053726 364 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI Johnson& Johnson Pharmaceutical Research& Development
18290604 1 Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.EBI Universidade de Lisboa
18247547 6 Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.EBI Cephalon, Inc.
17470393 6 Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.EBI Imperial College London
16078825 8 Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.EBI Schering Plough Research Institute
12190311 37 Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).EBI GSK
11312926 39 Development of orally active nonpeptidic inhibitors of human neutrophil elastase.EBI Cortech, Inc.
10669559 180 Protease inhibitors: current status and future prospects.EBI University of Queensland
9191965 58 Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase.EBI ZENECA Pharmaceuticals
7799404 22 Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones.EBI Marion Merrell Dow Research Institute
8064791 18 2,6-Disubstituted aryl carboxylic acids, leaving groups"par excellence" for benzisothiazolone inhibitors of human leukocyte elastase.EBI Sterling Winthrop Pharmaceutical Research Division
1578486 53 Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.EBI School of Chemistry and Biochemistry
1542092 38 Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones.EBI Boehringer Ingelheim Pharmaceuticals
1433188 7 Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.EBI Merck Research Laboratories
11294386 5 The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.EBI GlaxoWellcome Medicines Research Centre
11206469 14 Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.EBI Glaxo Wellcome Medicines Research Centre
11055335 27 Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.EBI Boehringer Ingelheim
10360758 10 Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors.EBI Palatin Technologies Inc.
21923104 12 HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale.EBI University of Bonn
21741848 66 Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.EBI Universit£ degli Studi di Firenze
20823284 9 Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.EBI Boehringer Ingelheim (Canada) Ltd.
20970895 4 2-Azetidinone--a new profile of various pharmacological activities.EBI Barkatullah University
20638756 1 Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.EBI Wichita State University
19841155 29 MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.EBI Merck Research Laboratories
20417587 14 Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats.EBI Chang Gung University
20102150 35 Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.EBI Johnson& Johnson Pharmaceutical Research and Development
19772295 5 Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.EBI Imperial College London SW7 2AZ
19665376 48 Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.EBI Merck Frosst Canada& Co.
20004577 6 Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa.EBI Korea Research Institute of Bioscience and Biotechnology
19908842 84 Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.EBI National Human Genome Research Institute
19904934 31 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.EBI University of Lisbon
19577470 49 Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.EBI ActivX Biosciences, Inc
3550086 31 Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.EBI TBA
 24 Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell cultureEBI TBA
 5 Synthesis of 7α-methoxy-2-(1,3-dithiolan-2-ylidene)cephem sulphones. A new series of human leukocyte elastase inhibitorsEBI TBA
 45 A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastaseEBI TBA
 8 Tricyclic cephems as inhibitors of human leukocyte elastase. thieno[3,4-c]cepham sulfones and pyrrolo[3,4-c]cepham sulfonesEBI TBA
 7 Tricyclic cephems as inhibitors of human leukocyte elastase. Furo[3,4-c]cepham sulfonesEBI TBA
 55 The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastaseEBI TBA
 18 Inhibitors of human leukocyte elastase. 3.1 inhibition by tetrahydrobenzisothiazolinylmethyl aryl carboxylatesEBI TBA
 14 Inhibitors of human leukocyte elastase. 2.1 synthesis and sar of benzisothiazolinylmethyl aryl ethersEBI TBA
 1 Phosphorous acid analogs of L-680,833, a potent monocyclic β-lactam inhibitor of human leukocyte elastaseEBI TBA
 12 Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastaseEBI TBA
 27 Synthesis and porcine pancreatic elastase inhibitory evaluation of 6α-(sulfonyl)oxy-and 6α-chloropenicillanate sulfone esters and 3α-(acyloxy)methyl-6α-chloropenam sulfonesEBI TBA
 46 1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhi...EBI TBA
 2 Synthesis of new thiazinoindole derivatives and their evaluation as inhibitors of human leukocyte elastase and other related serine proteasesEBI TBA
 18 Examination of peptidic α′,β-diamino-α,α-difluoroketones as inhibitors of human leukocyte elastaseEBI TBA
 19 A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastaseEBI TBA
 4 elastase inhibitors containing conformationally restricted lactams as P3-P2 dipeptide replacementsEBI TBA
 7 Janus compounds: dual inhibitors of proteinasesEBI TBA
 30 Enantioselective synthesis and antielastase activity of 1,3,4-trisubstituted and 3,4-disubstituted β-lactam antibioticsEBI TBA
 6 Inhibition of human leukocyte elastase. 7. Inhibition by 6-substituted penicillin amides.EBI TBA
 32 Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters.EBI TBA
 18 Inhibition of human leukocyte elastase. 5. Inhibition by 6-alkyl substituted penem benzyl esters.EBI TBA
 17 Inhibition of human leukocyte elastase (HLE) by novel bicyclic β-lactamsEBI TBA
 13 Cephem sulfones as inactivators of human leukocyte elastase. II. Keto-enol tautomerish in cephem-4-ketones.EBI TBA
 2 The effect of N-acyl substituents on the stability of monocyclic β-lactam inhibitors of human leukocyte elastaseEBI TBA
 1 Potential mechanism-based inhibitors of proteolytic enzymesEBI TBA
 6 Synthesis of a peptidyl 2,2-difluoro-3-aminopropionateEBI TBA
 1 A general synthesis of 4-alkyl/aryl substituted saccharinsEBI TBA
18701300 55 Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI University of Leipzig
17419055 30 Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.EBI Daiichi Asubio Pharma Co., Ltd
17145787 8 Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.EBI Gilead Sciences, Inc.
15588093 3 A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: discovery of potent and specific tripeptide inhibitors.EBI Boehringer Ingelheim (Canada) Ltd.
12668020 29 Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.EBI 3-Dimensional Pharmaceuticals, Inc.
12565935 5 Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors.EBI The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory
12540231 39 Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.EBI MRL Rome
12467634 67 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors.EBI currently NAEJA Pharmaceutical Inc.
12372533 69 P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12161131 1 Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.EBI Minase Research Institute
11844670 27 Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase.EBI Dainippon Pharmaceutical Co., Ltd.
11425539 23 Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.EBI Shionogi & Co., Ltd.
11327591 1 Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.EBI INETI
11212109 14 The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.EBI Roche Discover Welwyn
11150162 15 Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.EBI Colorado State University
11078188 20 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.EBI Shionogi & Co., Ltd
11078187 36 Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.EBI Shionogi & Co., Ltd
10866385 13 Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.EBI The Oxford Centre for Molecular Sciences
10639285 13 2-(diethylamino)thieno1,3??xazin-4-ones as stable inhibitors of human leukocyte elastase.EBI University of Leipzig
10522707 16 2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.EBI GlaxoWellcome Medicines Research Centre
10476876 1 Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation.EBI Fujisawa Pharmaceutical Co., Ltd.
10340616 6 Synthesis and in vitro and in vivo evaluation of the 2-(6'methoxy-3',4'-dihydro-1'-naphtyl)-4H-3,1-benzoxazin-4- one as a new potent substrate inhibitor of human leukocyte elastase.EBI Università degli Studi di L'Aquila
9873654 37 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.EBI GlaxoWellcome Research and Development
9873610 48 Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.EBI Boehringer Ingelheim (Canada) Ltd
9871780 85 Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.EBI Boehringer Ingelheim (Canada) Ltd
9871680 5 Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.EBI ProScript, Inc.
9871629 6 Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors.EBI Cinc
9822554 14 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
9822552 2 Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors.EBI Institut Jacques Monod (UMR CNRS 7592/Universités Paris VI and VII)
9767628 31 Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.EBI GlaxoWellcome Medicines Research Centre
9667976 58 beta-Lactam derivatives as inhibitors of human cytomegalovirus protease.EBI Boehringer Ingelheim (Canada) Ltd.
9651152 20 Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.EBI Hoechst Marion Roussel Inc.
9572899 19 Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase.EBI University of Leipzig
9406601 109 Peptidomimetic inhibitors of the human cytomegalovirus protease.EBI Boehringer Ingelheim Ltd.
9379436 46 Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.EBI ZENECA Pharmaceuticals
9341917 69 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.EBI Southern Methodist University
9341916 30 Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase.EBI Rhône-Poulenc Rorer
9191969 31 Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives.EBI Institut de Recherche Servier
8676347 39 Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.EBI ZENECA Pharmaceuticals
8176703 14 Design of orally active, non-peptidic inhibitors of human leukocyte elastase.EBI ZENECA Pharmaceuticals Group
7966161 45 Cephem sulfones as inactivators of human leukocyte elastase. 5. 7 alpha-Methoxy- and 7 alpha-chloro-1,1-dioxocephem 4-ketones.EBI Pharmacia Farmitalia Carlo Erba
7932559 42 Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.EBI Zeneca Pharmaceuticals Group
7932558 30 Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.EBI ZENECA Pharmaceuticals Group
7932532 23 Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.EBI A Business Unit of ZENECA Inc.
7877139 8 Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.EBI Sterling Winthrop Inc.
7837246 39 Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.EBI ZENECA Pharmaceuticals
7837244 33 Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.EBI ZENECA Pharmaceuticals
7837243 25 Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency.EBI ZENECA Pharmaceuticals
7837235 9 Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.EBI ZENECA Pharmaceuticals
7830264 16 Inhibition of human neutrophil elastase. 3. An orally active enol acetate prodrug.EBI Marion Merrell Dow Research Institute
7739015 12 Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase.EBI Sterling Winthrop Pharmaceuticals Research Division
7629790 32 New orally active serine protease inhibitors.EBI Minase Research Institute
7608910 1 Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones.EBI Merck Research Laboratories
7562931 41 Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.EBI ZENECA Pharmaceuticals
7473596 35 A novel class of cyclic beta-dicarbonyl leaving groups and their use in the design of benzisothiazolone human leukocyte elastase inhibitors.EBI Sterling Winthrop Pharmaceuticals Research Division
3848491 5 Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.EBI TBA
3844034 13 Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase.EBI TBA
3647139 9 Inhibition of human sputum elastase by substituted 2-pyrones.EBI TBA
3361575 65 (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase.EBI Searle Research and Development
2391693 17 Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.EBI Merck Sharp and Dohme Research Laboratories
2391692 27 Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.EBI Merck Sharp and Dohme Research Laboratories
2391691 55 Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.EBI Merck Sharp and Dohme Research Laboratories
2296031 48 Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.EBI Merrell Dow Research Institute
1479581 11 Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1.EBI Boehringer Ingelheim Pharmaceuticals
22803662 7 Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines.BDB Giresun University
20545486 1 Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-▀-lactam inhibitor of human leukocyte elastase.BDB University of Lisbon
11496832 7 Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors.BDB Università di Ferrara
19811924 23 Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury.BDB Dainippon Sumitomo Pharma Co
17850059 195 N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.BDB Montana State University