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341 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28318942 10 Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues.EBI Medical University of Lodz
27721146 22 (+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/sEBI University of Catania
28435535 8 Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
28105278 10 Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.EBI Mossakowski Medical Research Centre Polish Academy of Sciences
27676089 35 A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinityµ Opioid Receptor Antagonists.EBI Clinical Research Institute of Montreal
27301366 30 [Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.EBI Nanjing Medical University
27148755 75 Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacyµ-Opioid Receptor (MOR)/d-Opioid Receptor (DOR) Ligands.EBI University of Michigan
27234885 31 Evaluation of N-substituent structural variations in opioid receptor profile of LP1.EBI University of Catania
26713106 59 Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.EBI Vrije Universiteit Brussel
26713104 24 Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics.EBI University of Michigan
26944625 26 Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.EBI Medical University of Lodz
26785295 35 Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.EBI Medical University of Lodz
26656913 85 Multitarget opioid ligands in pain relief: New players in an old game.EBI University of Catania
26789491 44 Potentµ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.EBI Torrey Pines Institute for Molecular Studies
26712115 36 Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.EBI University of Arizona
26524472 75 Further Optimization and Evaluation of Bioavailable, Mixed-Efficacyµ-Opioid Receptor (MOR) Agonists/d-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities.EBI University of Michigan
26491810 35 Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin.EBI The University of Kansas
26330078 51 Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selectiveż-opioid receptor agonists.EBI Harvard Medical School
26323872 49 Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.EBI University of Arizona
26316468 53 Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors.EBI University of Arizona
26299827 43 Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.EBI University of Arizona
26125201 62 Structural Requirements for CNS Active Opioid Glycopeptides.EBI The University of Arizona
25168746 28 Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.EBI University of Monastir
25129170 20 'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode.EBI Clinical Research Institute of Montreal
25996309 49 Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), andż (KOR) Opioid Receptors.EBI Torrey Pines Institute for Molecular Studies
26005537 72 Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.EBI Medical University of Lodz
25898137 61 C7ß-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.EBI University of Bath
25559207 92 Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities.EBI Zhejiang University
25544687 60 Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.EBI Vrije Universiteit Brussel
25087049 56 Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.EBI National Health Research Institutes
25047937 9 Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.EBI Medical University of Lodz
25456075 16 Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.EBI TBA
25221662 24 Novel cyclic biphalin analogue with improved antinociceptive properties.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
24761755 76 Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.EBI University of Bath
24839540 26 In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated DmtEBI Vrije Universiteit Brussel
24613457 64 Endomorphin analogues with mixedµ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lackingß-arrestin2 recruitment activity.EBI Nanjing Medical University
24602401 40 [Dmt(1)]DALDA analogues with enhancedµ opioid agonist potency and with a mixedµ/ż opioid activity profile.EBI Nanjing Medical University
24641190 16 Development of a bioavailableµ opioid receptor (MOPr) agonist,d opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.EBI University of Michigan
15743203 272 3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.EBI University of Medicine& Dentistry of New Jersey-Robert Wood Johnson Medical School (UMDNJ-RWJMS)
23438330 174 Orvinols with mixed kappa/mu opioid receptor agonist activity.EBI University of Bath
23547584 19 Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.EBI Universit£ di Chieti-Pescara"G. d'Annunzio"
23419026 40 Opioid peptidomimetics: leads for the design of bioavailable mixed efficacyµ opioid receptor (MOR) agonist/d opioid receptor (DOR) antagonist ligands.EBI University of Michigan
23360448 18 Development of¿ opioid receptor antagonists.EBI Research Triangle Institute
2415705 4 Opioid receptor interactions and conformations of the 6 alpha and 6 beta epimers of oxymorphamine. Solid-state conformation of 6 alpha-oxymorphamine.EBI TBA
22325949 28 Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.EBI Clinical Research Institute of Montreal
23102273 60 Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.EBI Vrije Universiteit Brussel
22957923 20 The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2.EBI Biological Research Center of the Hungarian Academy of Sciences
22695132 56 Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).EBI Janssen Research and Development, L.L.C.
21978284 42 Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixedµ/d opioid receptor agonistic properties.EBI Vrije Universiteit Brussel
22677527 38 Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors.EBI University of Maryland
22394120 7 The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.EBI Universit£ di Chieti-Pescara G. d'Annunzio
21128594 93 Development of potent µ and d opioid agonists with high lipophilicity.EBI University of Arizona
20599386 46 Evaluation of N-substitution in 6,7-benzomorphan compounds.EBI University of Catania
20580236 60 Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.EBI University of Innsbruck and Center for Molecular Biosciences Innsbruck-CMBI
20547453 122 Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.EBI University of Arizona
20218625 27 "Carba"-analogues of fentanyl are opioid receptor agonists.EBI Clinical Research Institute of Montreal
20560643 71 Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.EBI University of Arizona
19362480 22 Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.EBI Kitasato University
19211245 27 Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A.EBI Harvard Medical School
18403056 8 Ligand binding to nucleic acids and proteins: Does selectivity increase with strength?EBI Universit£t des Saarlandes
18370374 12 Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.EBI Vrije Universiteit Brussel
18311909 10 Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.EBI Stanford University School of Medicine
18178091 24 Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).EBI University of Ferrara
18166466 12 Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors.EBI Harvard Medical School
17981041 79 Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.EBI McLean Hospital
18293909 5 Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.EBI University of Minnesota
18062664 13 Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.EBI Biological Research Center of the Hungarian Academy of Sciences
17659872 15 3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands.EBI University of Maryland
17395470 40 Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2.EBI Kyushu University
17267226 46 Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity.EBI Taisho Pharmaceutical Co., Ltd
16814543 14 Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide.EBI Tohoku Pharmaceutical University
16942034 19 Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.EBI University of Cagliari
16509592 101 Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.EBI University of Arizona
15857143 48 Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.EBI University La Sapienza
16033285 24 Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.EBI University of Innsbruck
15456262 32 Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].EBI Universit£ di Bologna
14998329 142 Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].EBI Southern Research Institute
14761209 15 Importance of phenolic address groups in opioid kappa receptor selective antagonists.EBI Research Triangle Institute
12699394 30 Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships.EBI University of Innsbruck
12570383 46 3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.EBI GlaxoSmithKline Research and Development
12954070 24 Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.EBI University of Innsbruck
12825951 54 Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.EBI Research Triangle Institute
11806723 20 Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.EBI University of Cagliary
12459023 46 Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.EBI University of Cagliari
12431065 72 Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.EBI University of Innsbruck
12139463 24 Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.EBI Research Triangle Institute
12036366 12 Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.EBI Universit£ degli Studi di Bologna
11311071 53 Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11300879 77 Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.EBI Research Triangle Institute
11300867 32 Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus.EBI University of Minnesota
11689075 20 Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.EBI University of Lausanne
11495579 24 Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.EBI Research Triangle Institute
11405645 13 Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.EBI University of Minnesota
10691681 17 Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.EBI Clinical Research Institute of Montr£al
10956208 121 Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists.EBI University of Catania
10229636 30 delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.EBI National Institute of Diabetes
10639287 62 Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10543877 25 Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.EBI Uppsala University
10479286 53 Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.EBI Southern Research Institute
9857087 63 Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile.EBI Vrije Universiteit Brussel
9836606 12 Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors.EBI University of Minnesota
9804688 51 Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.EBI University of Minnesota
9719602 24 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy.EBI University of Bristol
9667975 86 Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.EBI Southern Research Institute
9057856 53 Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid rEBI National Institute of Diabetes and Digestive and Kidney Diseases
9397176 28 Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.EBI University of Arizona
9301674 60 Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.EBI University of Ferrara
9288177 20 Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.EBI University of Ferrara
9288176 95 Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8642567 64 Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7739013 26 Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.EBI Research Triangle Institute
7739011 90 Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8164255 23 Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.EBI Clinical Research Institute of Montreal
7932569 116 Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties.EBI Virginia Commonwealth University
8064796 10 Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library.EBI Chiron Corporation
8035418 30 Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8201592 27 [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.EBI University of Arizona
8289188 30 Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.EBI University of Arizona
8230106 16 TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.EBI Clinical Research Institute of Montreal
8393489 25 A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.EBI Glaxo Group Research Ltd.
8390575 28 Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.EBI Universit£ di Catania
1311764 4 Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin.EBI Searle Research and Development
1323677 18 Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.EBI G.D. Searle and Company
1322988 60 Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodoEBI National Institute of Diabetes and Digestive and Kidney Diseases
1322987 34 Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors.EBI Research Triangle Institute
1648137 30 Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.EBI University of Arizona
1851843 96 Synthesis and structure-activity relationships of deltorphin analogues.EBI University of Ferrara
1849997 42 Function of negative charge in the"address domain" of deltorphins.EBI National Institute of Environmental Health Sciences
2167979 43 Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.EBI Universit£ Louis Pasteur
2153205 10 [D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.EBI University of Arizona
2537426 12 Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group.EBI University of Arizona
2536436 24 Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.EBI Smith Kline and French Laboratories
2831363 19 Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.EBI Eli Lilly and Company
2828622 71 Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.EBI INSERM
2845084 22 Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.EBI SRI International
3033248 3 Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists.EBI TBA
3007760 93 N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.EBI TBA
2878079 22 Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.EBI TBA
2999408 11 Hybromet: a ligand for purifying opioid receptors.EBI TBA
2999401 20 Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.EBI TBA
6150112 24 Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.EBI TBA
6296388 68 Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.EBI TBA
15115401 24 Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.EBI National Institutes of Environmental Health Sciences
12643945 36 Structure-activity relationships of some opiate glycosides.EBI Ultrafine UFC Ltd
12565965 45 Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.EBI Southern Research Institute
11425550 62 Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.EBI R. W. Johnson Pharmaceutical Research Institute
10782696 67 ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.EBI F. Hoffmann-La Roche Ltd.
11133084 14 Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.EBI Universit£ di Bologna
11078198 12 N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole.EBI University of Maryland
10866377 9 Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.EBI Universit£ di Napoli Federico II
10340622 47 Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.EBI Organon Laboratories Ltd.
10617086 21 Delta opioid binding selectivity of 3-ether analogs of naltrindole.EBI National Institute of Diabetes
10612597 31 Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.EBI Research Triangle Institute
10571174 25 (+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.EBI Research Triangle Institute
9871544 24 Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.EBI National Institute of Diabetes
9873603 23 Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.EBI University of Michigan
9873480 35 Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors.EBI Institute for Bioorganic Research
 17 Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivityEBI TBA
 51 EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonistsEBI TBA
22204910 17 Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.EBI Harvard Medical School
22197670 51 Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.EBI Kitasato University
22047797 16 Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.EBI Medical University of Lodz
21925887 10 Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.EBI University of Arizona
21870874 30 Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold.EBI Vrije Universiteit Brussel
21864951 6 Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents.EBI Wroclaw Medical University
21413804 21 Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.EBI Vrije Universiteit Brussel
21366266 66 Discovery of a potent and efficacious peptide derivative ford/µ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.EBI University of Arizona
21287991 43 Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.EBI Hungarian Academy of Sciences
21235243 35 Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.EBI University of Innsbruck
20692738 34 Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.EBI "Sapienza" Università di Roma
20637637 46 Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.EBI University of Cagliari
20617791 70 Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.EBI University of Arizona
20476738 14 Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.EBI Universit£ di Roma
20413312 17 Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans.EBI University of Debrecen
20137938 28 Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.EBI Vrije Universiteit Brussel
19932964 26 Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.EBI Fudan University
19762245 69 The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.EBI University of Arizona
19640720 4 Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence.EBI Institute of Chemical Biology
19621878 19 Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.EBI The University of Kansas
19827750 39 Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).EBI Clinical Research Institute of Montreal
19807094 45 The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.EBI University of Kansas
19788201 32 Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.EBI University of Michigan
19576786 129 Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.EBI Institute for Molecular Studies
19715279 20 Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.EBI The University of Kansas
19642675 60 Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.EBI University of Cagliari
19560919 28 Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.EBI Universit£ di Roma
1317407 7 Akuammine and Dihydroakuammine, Two Indolomonoterpene Alkaloids Displaying Affinity for Opioid ReceptorsEBI TBA
15984054 21 Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids.EBI TBA
 17 trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonistsEBI TBA
 35 Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesicEBI TBA
 8 Specific affinity labeling of μ opioid receptors in rat brain by S-activated sulfhydryldihydromorphine analogsEBI TBA
 16 Synthesis and biological properties of quaternized N-methylation analogs of D-Arg-2-dermorphin tetrapeptideEBI TBA
 4 A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrinEBI TBA
 38 The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptidesEBI TBA
 8 Topographical requirements for delta opioid ligands: The synthesis and biological properties of a cyclic analogue of deltorphin IEBI TBA
 6 New potent enkephalin analogs containing trifluoromethylamino acid residuesEBI TBA
 4 Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1EBI TBA
19435668 20 Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.EBI Medical University of Lodz
19253970 39 Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines.EBI University of Bath
19147366 60 Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.EBI McLean Hospital
19062273 41 Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.EBI Vrije Universiteit Brussel
18821747 45 The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.EBI University of Arizona
18800771 26 Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].EBI National University of Singapore
18680274 44 Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.EBI University of Cagliari
18572932 64 New endomorphin analogues containing alicyclic beta-amino acids: influence on bioactive conformation and pharmacological profile.EBI Hungarian Academy of Sciences
18490168 32 Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.EBI Lanzhou University
18468445 26 Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.EBI University of Queensland
18207400 17 Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.EBI Medical University of Lodz
17851080 6 A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.EBI University of Ferrara
17497839 72 Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.EBI Kobe Gakuin University
17339114 27 Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.EBI University of Cagliari
17329100 34 Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.EBI University of Arizona
17315860 40 Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.EBI Clinical Research Institute of Montreal
17266203 29 Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).EBI Medical University
17234422 118 Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor.EBI Taisho Pharmaceutical Co., Ltd
17228874 18 Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.EBI Hungarian Academy of Sciences
17201419 93 Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.EBI University of Arizona
17188879 16 Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization.EBI Lanzhou University
17142049 40 Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.EBI Kobe Gakuin University
16949282 12 Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.EBI Kobe Gakuin University
16913729 9 Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.EBI National University of Singapore
16828552 20 Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.EBI University of Arizona
16759107 18 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.EBI Universidad de Santiago de Compostela
16750366 104 Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.EBI Institute for Molecular Studies
16682191 21 Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.EBI Lanzhou University
16483774 66 Identification of potent phenyl imidazoles as opioid receptor agonists.EBI Johnson & Johnson Pharmaceutical Research & Development
16366592 33 Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).EBI University of Cagliari
16335927 48 Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.EBI Kobe Gakuin University
16275086 18 Synthesis and biological activity of the first cyclic biphalin analogues.EBI University of Arizona
16183273 12 New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.EBI Kobe Gakuin University
15887972 8 A new structural motif for mu-opioid antagonists.EBI Vrije Universiteit Brussel
15863298 20 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.EBI University of Catania
15857130 37 Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models.EBI University of Szeged
15857121 1 Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.EBI Università degli Studi di Napoli "Federico II"
15658871 28 Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.EBI Kobe Gakuin University
15588089 10 Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.EBI University of Cagliary
15456245 44 Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.EBI Johnson & Johnson Pharmaceutical Research & Development
15214786 64 Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.EBI Kobe Gakuin University
15163203 45 Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime.EBI University of Innsbruck
14736254 70 Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues.EBI Biological Research Center of the Hungarian Academy of Sciences
14711314 63 Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.EBI University of Maryland
12954053 39 Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2.EBI University of Maryland
12852751 34 Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.EBI Kobe Gakuin University
12672238 3 Mechanism of action of the diazabicyclononanone-type kappa-agonists.EBI Universität Würzburg
12657261 32 Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.EBI Tohoku Pharmaceutical University
12459018 6 Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.EBI National Institute of Environmental Health Sciences
12372527 27 Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin.EBI Institute for Molecular Studies
12190304 10 Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors.EBI University of Maryland
11958984 24 Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.EBI Tohoku Pharmaceutical University
11755345 45 Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.EBI NIDDK
11212102 24 Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.EBI Tohoku Pharmaceutical University
11150176 9 Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors.EBI University of Maryland
10893314 24 Potent and selective indolomorphinan antagonists of the kappa-opioid receptor.EBI University of Minnesota
10866400 18 4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.EBI Research Triangle Institute
10843229 92 Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.EBI R. W. Johnson Pharmaceutical Research Institute
10841790 24 Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.EBI Istituto di Chimica Farmaceutica e Tossicologica
10741545 36 Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands.EBI Pfizer Inc
10691683 22 Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.EBI University of Arizona
10639279 26 Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.EBI The University of Arizona
10585210 60 Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.EBI University of Ferrara
10479285 17 The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.EBI Clinical Research Institute of Montreal
10340623 31 Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.EBI Organon Laboratories Ltd.
9873693 24 N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.EBI Research Triangle Institute
9822547 41 De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.EBI The University of Arizona
9767649 24 N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.EBI Research Triangle Institute
9599247 57 Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.EBI Research Triangle Institute
9288174 24 Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex.EBI TBA
9276018 47 Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.EBI Oregon State University
9258365 28 Helix-inducing alpha-aminoisobutyric acid in opioid mimetic deltorphin C analogues.EBI National Institute of Environmental Health Sciences
9083489 30 Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.EBI Hungarian Academy of Sciences
8576920 34 Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.EBI University of Ferrara
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI Lilly Research Laboratories
8410998 129 Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.EBI Lilly Research Laboratories
8355251 8 Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8289187 47 Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.EBI University of Arizona
8254604 50 Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.EBI University of Ferrara
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8097539 10 Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.EBI Oregon State University
8057274 18 Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.EBI Lilly Research Laboratories
7932540 38 A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.EBI National Institute of Diabetes and Digestive and Kidney Diseases
7908696 45 Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide.EBI Searle
7608905 24 Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the"message" sequence.EBI Oregon State University
7562933 24 Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties.EBI Tohoku College of Pharmacy
7490727 72 (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.EBI National Institute of Diabetes and Digestive and Kidney Diseases
2903246 58 Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.EBI University of Arizona
2876099 51 Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.EBI TBA
2845081 24 Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.EBI UA 498 CNRS
2822930 48 Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.EBI Clinical Research Institute of Montreal
2563773 26 New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties.EBI BOC Technical Center
2537427 24 Dermorphin analogues carrying an increased positive net charge in their"message" domain display extremely high mu opioid receptor selectivity.EBI Clinical Research Institute of Montreal
2170652 25 Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics.EBI Anaquest Pharmaceuticals
1714957 12 Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.EBI Hebrew University of Jerusalem
1671414 10 Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds.EBI Istituto Superiore di Sanità
1656045 26 Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.EBI Clinical Research Institute of Montreal
1360025 27 Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.EBI Oregon State University
1346276 25 Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide.EBI G. D. Searle and Company
1335080 20 Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.EBI University of Ferrara
1331451 68 Conformationally restricted deltorphin analogues.EBI Clinical Research Institute of Montreal
1320122 55 Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.EBI University of Arizona
1313878 36 Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.EBI National Institute of Environmental Health Sciences
18311899 26 Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs.BDB University of Maryland
15831442 46 Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.BDB Taisho Pharmaceutical Co., Ltd
15383632 15 Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.BDB Temple University
15131245 86 SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization.BDB Sanofi-Synthelabo Recherche
14729121 29 In vitro opioid activity profiles of 6-amino acid substituted derivatives of 14-O-methyloxymorphone.BDB University of Innsbruck
12887410 15 Binding characteristics of [3H]14-methoxymetopon, a high affinity mu-opioid receptor agonist.BDB University of Innsbruck
12842269 16 Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.BDB University of Michigan
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB Pudue Pharma Discovery Research
12538838 14 Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.BDB Taisho Pharmaceutical Co.
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
12192085 52 Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.BDB Case Western Reserve University
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
11270320 11 Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors.BDB University of Maryland
11082453 77 ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.BDB Abbott Laboratories
10585536 23 Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays.BDB Hungarian Academy of Sciences
10374926 2 Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans.BDB Hungarian Academy of Sciences
9700760 21 Interaction of agonist peptide [3H]Tyr-D-Ala-Phe-Phe-NH2 with mu-opioid receptor in rat brain and CHO-mu/1 cell line.BDB Hungarian Academy of Sciences
9694962 65 Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.BDB Memorial Sloan-Kettering Cancer Center
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Janssen Research Foundation
8887981 72 A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.BDB Abbott Laboratories
8564266 77 Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed.BDB Vrije Universiteit
8012715 38 GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.BDB Glaxo Group Research Ltd.
7910212 34 Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.BDB Yamanouchi Pharmaceutical Co. Ltd.
7815359 29 Characterization of the cloned human mu opioid receptor.BDB University of Pennsylvania
7582507 14 RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist.BDB Syntex Discovery Research
7562497 127 Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.BDB R.W. Johnson Pharmaceutical Research Institute
3033464 11 Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17.BDB Burroughs Wellcome Company
2531826 24 [125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor.BDB NIDA Addiction Research Center
1982626 30 Neurochemical profile of eltoprazine.BDB Duphar B.V.
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
1620241 6 SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum.BDB SANDOZ Pharma Ltd.
19041249 48 Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.BDB Nippon Shinyaku Co.
16686530 68 Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.BDB University of Arizona at Tucson
17539621 17 Synthesis of Stable and Potent delta/mu Opioid Peptides: Analogues of H-Tyr-c[d-Cys-Gly-Phe-d-Cys]-OH by Ring-Closing Metathesis.BDB Universita degli Studi
17927164 24 Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.BDB University of Arizona at Tucson
17516639 29 Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.BDB University of Arizona at Tucson
18266313 30 A Structure-Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are delta/mu Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists.BDB University of Arizona at Tucson