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100 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28051871 100 Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.EBI Instituto de Qu£mica M£dica (IQM-CSIC)
27810243 87 Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.EBI AstraZeneca
26990539 79 Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)▀ Agonist.EBI Vitae Pharmaceuticals Inc
26683992 25 2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.EBI Eli Lilly and Company
26218343 76 Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.EBI Eli Lilly and Company
25978072 53 Synthesis and Biological Evaluation of Cyclopentaquinoline Derivatives as Nonsteroidal Glucocorticoid Receptor Antagonists.EBI TBA
25879485 60 Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.EBI Seragon Pharmaceuticals
25941555 75 Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.EBI Merck Research Laboratories
24980053 153 Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.EBI Bristol-Myers Squibb Co.
25516791 177 Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.EBI Boehringer Ingelheim Pharmaceuticals Inc
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI Phenex Pharmaceuticals AG
25187277 136 Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.EBI Takeda Pharmaceutical Co., Ltd
24755427 107 The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.EBI AstraZeneca
24738581 81 Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.EBI Pfizer Inc
24630411 38 Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.EBI Merck Research Laboratories
24656565 73 Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.EBI Boehringer Ingelheim Pharmaceuticals Inc
24506830 91 Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.EBI Boehringer Ingelheim Pharmaceuticals Inc
24446728 30 Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.EBI Eli Lilly and Company
24239189 85 Substituted phenyl as a steroid A-ring mimetic: providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands.EBI Boehringer Ingelheim Pharmaceuticals Inc
24215891 107 Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.EBI Boehringer Ingelheim Pharmaceuticals Inc
24157365 23 Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.EBI Pfizer Inc
24074876 17 Synthesis of sterically encumbered 11▀-aminoprogesterone derivatives and evaluation as 11▀-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.EBI University of Alberta
23953070 146 Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.EBI Ironwood Pharmaceuticals, Inc.
23916594 92 Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.EBI Bristol-Myers Squibb Co.
23958516 61 Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.EBI Takeda Pharmaceutical Co., Ltd
23777778 101 Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.EBI Merck Research Laboratories
23279862 1 Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity.EBI Universidad del Valle
21129964 28 Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.EBI Merck Research Laboratories
20812681 24 Synthesis and biochemical characterization of a series of 17a-perfluoroalkylated estradiols as selective ligands for estrogen receptora.EBI Charles University in Prague
20727743 64 Discovery of quinolines as selective glucocorticoid receptor agonists.EBI Bayer Schering Pharma AG
20202837 51 The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.EBI Medicines Research Centre
18952422 5 The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.EBI GlaxoSmithKline
23079530 27 Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.EBI Pfizer Inc
22866979 19 Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.EBI Pfizer Inc
21073190 135 Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists.EBI Bristol-Myers Squibb Co.
20735001 145 Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.EBI Boehringer Ingelheim Pharmaceuticals Inc
20672822 108 Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.EBI Pfizer Inc
20672820 92 Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.EBI Pfizer Inc
20638844 25 1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.EBI Pfizer Inc
20510622 142 Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.EBI Chinese Academy of Sciences
19863083 25 The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.EBI Wyeth Research
18722119 55 1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.EBI Wyeth Research
18504132 51 7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.EBI Wyeth Research
18513967 103 Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.EBI Ligand Pharmaceuticals
18032610 4 Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.EBI Ligand Pharmaceuticals
18318463 53 Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).EBI Wyeth Research
17692519 108 Identification of dissociated non-steroidal glucocorticoid receptor agonists.EBI Boehringer Ingelheim Pharmaceuticals Inc
17118655 73 Alpha-methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands.EBI Boehringer Ingelheim Pharmaceuticals Inc
17181172 94 Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.EBI Boehringer Ingelheim Pharmaceuticals Inc
16250653 22 Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.EBI Universit£ di Perugia
16112571 93 Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand.EBI Boehringer Ingelheim Pharmaceuticals Inc
15293993 172 Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.EBI Abbott Laboratories
12238914 48 6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.EBI Women's Health Research Institute
8627601 169 Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.EBI Ligand Pharmaceuticals Inc
15080982 122 Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.EBI Abbott Laboratories
12781198 108 Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.EBI Ligand Pharmaceuticals
12781197 59 Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.EBI Ligand Pharmaceuticals
10743938 103 Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.EBI Ligand Pharmaceuticals
22074142 89 Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.EBI Takeda Pharmaceutical Co., Ltd
21963986 162 Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.EBI Boehringer Ingelheim Pharmaceuticals Inc
21899328 244 Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791EBI Bristol-Myers Squibb Co.
21786805 130 Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.EBI Vitae Pharmaceuticals
21324689 74 Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.EBI Ligand Pharmaceuticals
21349714 118 Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation.EBI Ligand Pharmaceuticals
21316964 108 Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.EBI Ligand Pharmaceuticals
24900294 72 Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine FibroidsEBI TBA
21115247 64 Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.EBI Ligand Pharmaceuticals
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
20430618 21 Optimisation of a pyrazole series of progesterone antagonists; Part 1.EBI Pfizer Inc
20408553 27 Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.EBI Pfizer Inc
19595590 49 Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.EBI GlaxoSmithKline
19606870 53 Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).EBI Merck Research Laboratories
18553958 28 A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.EBI Ligand Pharmaceuticals Inc
18038968 26 (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.EBI Eli Lilly and Company
17587578 45 Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.EBI Argenta Discovery Ltd
17553679 148 5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.EBI Ligand Pharmaceuticals
16759088 38 The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.EBI University of Innsbruck
15081010 66 Discovery of novel nonsteroidal glucocorticoid receptor modulators.EBI Abbott Laboratories
12954062 140 5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.EBI Ligand Pharmaceuticals Inc
11520196 81 Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.EBI Abbott Laboratories
10230628 95 Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.EBI Ligand Pharmaceuticals
9871534 95 New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.EBI Ligand Pharmaceuticals
9784110 81 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.EBI Ligand Pharmaceuticals Inc
9464360 145 5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.EBI Ligand Pharmaceuticals Inc
8709117 7 New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.EBI Université P. et M. Curie
26568144 8 Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia.EBI Eli Lilly and Company
30144697 66 Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-? agonists (SERBAs).EBI Marquette University
29424542 138 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.EBI AstraZeneca
29741897 62 Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.EBI TBA
28043796 84 Discovery of new selective glucocorticoid receptor agonist leads.EBI Bayer Pharma AG
28479196 2 Conformational control in structure-based drug design.EBI Allergan Inc
28937774 107 Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.EBI AstraZeneca
29300474 45 Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.EBI Pfizer Inc
28454849 48 Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.EBI Takeda Pharmaceutical Co., Ltd
16078847 30 Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.BDB Abbott Laboratories
17681466 61 Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists.BDB Boehringer Ingelheim Pharmaceuticals Inc
17705362 43 Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.BDB Ligand Pharmaceuticals Inc