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77 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27050842 39 Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.EBI Northwestern University
26120733 36 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.EBI Northwestern University
25602734 4 Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.EBI Vibrant Pharma Inc.
25489882 63 Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
25522110 21 Structure-based design of bacterial nitric oxide synthase inhibitors.EBI University of California
25149509 30 Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
24758147 31 Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.EBI Northwestern University
24472039 39 Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.EBI Northwestern University
24447275 33 Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.EBI Northwestern University
24660051 24 An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.EBI Northwestern University
23993333 27 Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.EBI Northwestern University
23867386 31 In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.EBI Northwestern University
23458846 16 Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.EBI Northwestern University
23352768 21 Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.EBI University of California
23451760 18 Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
22831803 9 New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.EBI Universit£ de Caen Basse-Normandie
22370270 30 Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).EBI NeurAxon Inc.
19144449 22 Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.EBI Christian-Albrechts-University of Kiel
17317165 77 Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.EBI NeurAxon Inc.
16821802 30 Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.EBI Queen's University
14736250 50 Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.EBI Northwestern University
12699384 69 Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
14667223 72 Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.EBI Northwestern University
11472219 27 Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
9397167 15 Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.EBI Northwestern University
12482425 20 Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.EBI Institut Henri Beaufour
11133088 46 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.EBI Northwestern University
22370337 30 Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
22318159 36 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.EBI NeurAxon Inc.
22175766 45 Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.EBI NeurAxon Inc.
22280820 53 Novel inhibitors of nitric oxide synthase with antioxidant properties.EBI Universit£ degli Studi di Catania
21699209 75 Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.EBI NeurAxon Inc.
21809851 21 Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.EBI Northwestern University
21665485 4 Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.EBI North-West University
21410186 43 Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
21334118 1 Synthesis and biological evaluation of indazole derivatives.EBI UNED
20958055 133 Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.EBI Northwestern University
20933416 33 N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.EBI Università G. d'Annunzio
20833542 16 Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.EBI Northwestern University
20673724 33 Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
20441173 19 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.EBI University of Pennsylvania
19963381 18 Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.EBI Northwestern University
19505081 3 Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.EBI Institute of Marine Science
 16 Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthaseEBI TBA
 10 1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidineEBI TBA
19537690 24 L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.EBI Northwestern University
19268602 18 Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.EBI Northwestern University
19125620 96 Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.EBI Northwestern University
18502134 55 Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.EBI Université de Versailles
17395463 14 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.EBI UPRES-EA 3915
17239601 33 Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.EBI Northwestern University
17034131 19 Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.EBI Northwestern University
14998342 73 Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.EBI Pfizer Global Research and Development
11784131 2 Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.EBI Universidad de Granada
11354365 11 Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.EBI Université de Caen
11327581 44 Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.EBI AstraZeneca R&D Charnwood
11327580 73 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.EBI AstraZeneca R&D Charnwood
11133090 2 Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.EBI Wake Forest University
10571154 8 Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.EBI Wake Forest University Winston-Salem
10498210 27 A new class of selective and potent inhibitors of neuronal nitric oxide synthase.EBI Pfizer Inc. Groton
9651169 49 Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.EBI Abbott Laboratories
27250740 15 Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.BDB University of California , Irvine
25089924 19 The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases.BDB University of California at Irvine
19663506 21 Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.BDB The University of Texas
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB Pudue Pharma Discovery Research
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
19296678 18 Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.BDB University of California at Irvine
14718923 12 Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.BDB University of California at Irvine
17614291 24 Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors.BDB Northwestern University
17425297 18 Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.BDB Northwestern University