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136 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27050842 39 Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.EBI Northwestern University
26120733 36 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.EBI Northwestern University
25602734 4 Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.EBI Vibrant Pharma Inc.
25489882 63 Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
25522110 21 Structure-based design of bacterial nitric oxide synthase inhibitors.EBI University of California
25149509 30 Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
24758147 31 Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.EBI Northwestern University
24472039 39 Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.EBI Northwestern University
24447275 33 Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.EBI Northwestern University
24660051 24 An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.EBI Northwestern University
23993333 27 Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.EBI Northwestern University
23867386 31 In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.EBI Northwestern University
23458846 16 Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.EBI Northwestern University
23352768 21 Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.EBI University of California
23451760 18 Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
21684157 68 Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.EBI Nycomed GmbH
22840695 52 Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.EBI NeurAxon Inc.
22335555 43 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.EBI NeurAxon Inc.
22831803 9 New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.EBI Universit£ de Caen Basse-Normandie
24900459 53 NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with -Opioid Agonist Activity.EBI TBA
22420844 86 First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.EBI NeurAxon Inc.
22370270 30 Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).EBI NeurAxon Inc.
21923116 40 Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.EBI NeurAxon Inc.
19144449 22 Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.EBI Christian-Albrechts-University of Kiel
18083522 15 N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.EBI Christian-Albrechts-University of Kiel
18261902 2 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases.EBI University of Strathclyde
18024030 110 Discovery of a series of aminopiperidines as novel iNOS inhibitors.EBI Adolor Corporation
17317165 77 Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.EBI NeurAxon Inc.
16821802 30 Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.EBI Queen's University
15357988 87 Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.EBI Merck Research Laboratory
15357982 18 Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.EBI Pfizer Inc.
14761191 19 5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.EBI Pfizer Inc.
14736250 50 Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.EBI Northwestern University
12699384 69 Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
12620067 47 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.EBI AstraZeneca R& D Charnwood
11931623 6 Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.EBI Pfizer Inc.
11472219 27 Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
10956202 51 Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.EBI Northwestern University
10447959 30 N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
9554868 40 2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).EBI Pfizer Inc.
9733492 54 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.EBI Pfizer Inc.
9667974 150 N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.EBI Glaxo Wellcome Research and Development
9397167 15 Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.EBI Northwestern University
9288162 40 Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.EBI Northwestern University
9191968 88 Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.EBI Glaxo Wellcome Research and Development
8576908 33 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.EBI G. D. Searle Research and Development
12482425 20 Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.EBI Institut Henri Beaufour
12781178 33 Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.EBI Schering AG
10741561 48 Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.EBI Glaxo Wellcome Research and Development
11133088 46 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.EBI Northwestern University
 1 Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidineEBI TBA
22370337 30 Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
22318159 36 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.EBI NeurAxon Inc.
22175766 45 Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.EBI NeurAxon Inc.
22280820 53 Novel inhibitors of nitric oxide synthase with antioxidant properties.EBI Universit£ degli Studi di Catania
22182498 71 Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.EBI Afraxis
21699209 75 Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.EBI NeurAxon Inc.
21986586 124 Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.EBI Kalypsys Inc.
21824773 46 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.EBI NeurAxon Inc.
21813276 56 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.EBI NeurAxon Inc.
21809851 21 Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.EBI Northwestern University
20931971 155 Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOEBI Kalypsys, Inc
21665485 4 Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.EBI North-West University
21482467 28 Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.EBI GlaxoSmithKline R&D
21410186 43 Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
21334118 1 Synthesis and biological evaluation of indazole derivatives.EBI UNED
20958055 133 Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.EBI Northwestern University
20933416 33 N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.EBI Università G. d'Annunzio
20833542 16 Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.EBI Northwestern University
20673724 33 Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
20441173 19 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.EBI University of Pennsylvania
19963381 18 Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.EBI Northwestern University
19679481 29 Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.EBI UNED
19505081 3 Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.EBI Institute of Marine Science
 44 Inhibition of nitric oxide synthase by benzoxazolonesEBI TBA
 24 Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthaseEBI TBA
 16 Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthaseEBI TBA
 10 1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidineEBI TBA
19537690 24 L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.EBI Northwestern University
19323559 19 Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.EBI Washington University School of Medicine
19268602 18 Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.EBI Northwestern University
19125620 96 Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.EBI Northwestern University
18502134 55 Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.EBI Université de Versailles
18477512 118 Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.EBI Instituto de Química Médica
18457385 41 Recent developments in fragment-based drug discovery.EBI Astex Therapeutics Ltd.
17395463 14 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.EBI UPRES-EA 3915
17239601 33 Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.EBI Northwestern University
17034131 19 Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.EBI Northwestern University
16033258 51 Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.EBI Sanofi-Aventis
15911272 21 Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.EBI Nagoya City University
15808455 39 Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.EBI Merck Research Laboratories
15713387 18 Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives.EBI Dainippon Pharmaceutical Co., Ltd
15501067 51 Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.EBI Merck Research Laboratories
15163211 51 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.EBI AstraZeneca R&D Charnwood
14998342 73 Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.EBI Pfizer Global Research and Development
14741281 36 Fluorinated dihydroquinolines as potent n-NOS inhibitors.EBI Schering AG
12392746 18 3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.EBI Pharmacia
12182860 72 Dihydroquinolines as novel n-NOS inhibitors.EBI Schering AG
12086480 65 Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.EBI Aventis Pharma
12031315 6 Novel lipoic acid analogues that inhibit nitric oxide synthase.EBI Institute Henri Beaufour
11784131 2 Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.EBI Universidad de Granada
11551770 40 Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.EBI Pharmacia
11354365 11 Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.EBI Université de Caen
11327581 44 Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.EBI AstraZeneca R&D Charnwood
11327580 73 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.EBI AstraZeneca R&D Charnwood
11133090 2 Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.EBI Wake Forest University
10987430 86 Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.EBI Merck Research Laboratories Rahway
10571154 8 Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.EBI Wake Forest University Winston-Salem
10498210 27 A new class of selective and potent inhibitors of neuronal nitric oxide synthase.EBI Pfizer Inc. Groton
10346937 15 Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.EBI Wake Forest University
9873583 4 Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.EBI Université de Rennes 1
9651169 49 Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.EBI Abbott Laboratories
9526553 6 Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.EBI Searle
9438025 54 Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.EBI G. D. Searle Research and Development
27250740 15 Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.BDB University of California , Irvine
25089924 19 The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases.BDB University of California at Irvine
19663506 21 Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.BDB The University of Texas
21138269 17 Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .BDB University of California, Irvine
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB Pudue Pharma Discovery Research
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
18849972 45 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.BDB The Scripps Research Institute
19374401 103 Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.BDB Kalypsys Inc.
19296678 18 Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.BDB University of California at Irvine
14718923 12 Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.BDB University of California at Irvine
17614291 24 Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors.BDB Northwestern University
17425297 18 Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.BDB Northwestern University