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296 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28277660 30 Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.EBI Shanghai Institute of Materia Medica
28076827 27 New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.EBI Universit£ degli Studi di Bari"Aldo Moro"
27918994 18 Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPAR¿ agonists.EBI University of Innsbruck
28117121 9 Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR¿ and SUR agonists.EBI Al-Azhar University
27876250 60 Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI Jagiellonian University Medical College
27560282 11 Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR)¿ partial agonists.EBI University of Innsbruck
27569195 16 New telmisartan-derived PPAR¿ agonists: Impact of the 3D-binding mode on the pharmacological profile.EBI Universit£t Innsbruck
27815118 112 Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists.EBI Galderma R&D
27591006 24 Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.EBI The University of Tokyo
27326332 66 Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI Bristol-Myers Squibb Company
26974385 11 Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptorsa antagonists.EBI Universit£"G. d'Annunzio"
26988801 55 Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI Jagiellonian University Medical College
26819660 82 SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor.EBI Central Pharmaceutical Research Institute
27020685 4 Synthetic approaches to the 2014 new drugs.EBI Pfizer Inc.
26731300 3 Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.EBI Max Planck Institute for Molecular Genetics
26595749 77 N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators.EBI Goethe-University Frankfurt
26774923 26 Design, synthesis, and biological evaluation of novel thiazolidinediones as PPAR¿/FFAR1 dual agonists.EBI Suez Canal University
26708109 10 Design and synthesis of novel Y-shaped barbituric acid derivatives as PPAR¿ activators.EBI National Institute of Pharmaceutical Education and Research (NIPER)
26707398 2 Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum.EBI Northwest A&F University
26258602 39 Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.EBI Pfizer Inc.
26226490 23 Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.EBI IQM-CSIC
26048793 91 Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.EBI Genentech
25982078 13 Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists.EBI Sookmyung Women's University
25583100 107 Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.EBI Goethe University Frankfurt
25262940 3 2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPAR¿ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes.EBI University of Copenhagen
25938459 1 Amorfrutins Are Natural PPAR¿ Agonists with Potent Anti-inflammatory Properties.EBI Max Planck Institute for Molecular Genetics
25890697 6 Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI Punjabi University
25734377 11 Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage.EBI Universitat Rovira i Virgili (URV)
25815144 17 Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.EBI Daiichi Sankyo Co., Ltd.
25978962 8 Separation and peroxisome proliferator-activated receptor-¿ agonist activity evaluation of synthetic racemic bavachinin enantiomers.EBI Shanghai University of Traditional Chinese Medicine
25686852 191 Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists.EBI Bristol-Myers Squibb Research and Development (R&D)
25575659 124 SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI Goethe-University Frankfurt
25497132 34 Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175.EBI Universit£ degli Studi di Bari 'Aldo Moro'
25037914 76 Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.EBI Goethe-University Frankfurt
25022880 24 Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa.EBI Goethe-University Frankfurt
25017035 20 Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPAR¿ agonists.EBI Okayama University
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
24856059 7 trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-a.EBI Korea University
25491112 19 Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists.EBI National Institute of Pharmaceutical Education and Research (NIPER)
25462281 17 Structural development studies of PPARs ligands based on tyrosine scaffold.EBI Universit£"G. d'Annunzio"
25333853 6 Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.EBI Karl-Franzens-University Graz
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.EBI Phenex Pharmaceuticals AG
25255039 45 Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.EBI Goethe University Frankfurt
24821375 5 The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.EBI Korea University
24745969 36 Identification of the first potent, selective and bioavailable PPARa antagonist.EBI Inception Sciences
9836620 94 N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.EBI Glaxo Wellcome Research and Development
23294830 88 Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.EBI Amgen, Inc.
23286787 18 Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.EBI Helmholtz Centre for Infection Research
23265844 18 The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.EBI The University of Sydney
23265881 49 Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.EBI Pfizer Inc.
24900572 54 Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.EBI Pfizer Inc.
23171045 38 New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.EBI Universit� degli Studi di Bari&quo
17533125 36 Co-crystal structure guided array synthesis of PPARgamma inverse agonists.EBI GlaxoSmithKline
17482722 22 QSAR analysis of PPAR-gamma agonists as anti-diabetic agents.EBI Central Drug Research Institute
21414782 178 Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy.EBI GlaxoSmithKline Pharmaceuticals
20444603 2 Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).EBI Rikkyo University
20128594 51 Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.EBI GlaxoSmithKline
23186307 2 PPAR¿ agonist from Chromolaena odorata.EBI Hebei Medical University
23102891 34 Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.EBI Universit£ degli Studi G. d'Annunzio
23084275 48 Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1).EBI Daiichi Sankyo Co., Ltd
22081932 32 Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.EBI Istituto Tumori"Giovanni Paolo II"
23130964 25 Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.EBI ZAFES/LiFF/OSF Goethe-University Frankfurt
22934537 4 Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿.EBI Universit£ di Napoli Federico II
22424975 4 Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.EBI National Kaohsiung Normal University
23031596 21 Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.EBI Chungnam National University
23022278 14 Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.EBI Okayama University
23137448 16 Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa.EBI Universit£ G. d'Annunzio
21800856 50 Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI University of Innsbruck
22939697 4 Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-a receptors.EBI Washington University School of Medicine
22324546 55 Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.EBI Institut Pasteur Korea
22260081 12 Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.EBI Universit£ Lille-Nord de France
22582973 21 Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.EBI Trinity College
22727448 16 Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPAR¿ modulators.EBI Daiichi Sankyo Co., Ltd.
22564380 624 Activity landscape modeling of PPAR ligands with dual-activity difference maps.EBI Universidad Nacional Aut£noma de M£xico
22534184 87 Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo.EBI Seoul National University
22424300 3 Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma.EBI Korea University
22579420 45 Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.EBI Korea Institute of Science and Technology
24936232 16 Discovery of Potent Dual PPARa Agonists/CB1 Ligands.EBI TBA
22503460 37 Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists.EBI Takeda Pharmaceutical Company, Ltd
22381047 30 Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.EBI Chungnam National University
21218783 117 Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI Johnson& Johnson Pharmaceutical Research and Development
21128600 16 Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship.EBI Okayama University
20527969 27 Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic acids as peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonists with comparable antidiabetic efficacy to rosiglitazone.EBI Kyorin Pharmaceutical Co., Ltd.
20299214 20 (S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists.EBI Institute of Pharmacology and Toxicology
20219371 22 Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.EBI Daiichi Sankyo Co., Ltd
19879669 3 Identification of (beta-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor gamma activity.EBI Sookmyung Women's University
20138762 5 Acidic elements in histamine H(3) receptor antagonists.EBI Johann Wolfgang Goethe University
20073471 15 Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.EBI The University of Mississippi
19817384 2 Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.EBI Mount Sinai School of Medicine
19574056 25 Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.EBI Chinese Academy of Sciences
18329752 14 Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.EBI Graduate School of the Chinese Academy of Sciences
18976908 18 Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety.EBI Zydus Research Centre
18826205 61 Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.EBI Seoul National University
18511276 86 Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.EBI Bristol-Myers Squibb R&D
18272370 2 Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.EBI USDA-ARS
17062777 32 Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.EBI Bristol-Myers Squibb
18155554 87 Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.EBI Johnson& Johnson Pharmaceutical Research and Development
17964792 31 Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI Nippon Shinyaku Co., Ltd
18162399 37 SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.EBI University of Tokyo
18280733 27 Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.EBI Nippon Shinyaku Co., Ltd
18083521 4 Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.EBI Central Drug Research Institute
18291645 108 Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.EBI Bristol-Myers Squibb Research and Development
18029176 66 Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.EBI Johnson& Johnson
17560785 12 Design of a partial PPARdelta agonist.EBI Novo Nordisk A/S
17010604 3 Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).EBI Fudan University
17005393 35 Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.EBI Lilly Research Laboratories
16821769 16 Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.EBI University of Mississippi
16617018 4 Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.EBI University of Tokyo
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15546740 41 Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.EBI Lilly Research Laboratories
12951090 57 O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.EBI Merck Research Laboratories
10714503 18 Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.EBI Sankyo Co., Ltd.
22342624 2 Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.EBI Korea University
22341573 39 Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists.EBI Universit£ degli Studi di Bari 'Aldo Moro'
22185225 2 Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.EBI The University of Tokyo
22225641 13 Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists.EBI Daiichi Sankyo Co., Ltd
22070604 150 Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators.EBI Merck Research Laboratories
22209730 73 A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides.EBI Takeda Pharmaceutical Company Ltd
22197396 57 Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.EBI Kyoto Pharmaceutical Industries
22133631 76 Discovery of cyclic amine-substituted benzoic acids as PPARa agonists.EBI Kyorin Pharmaceutical Co., Ltd
22051054 18 Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.EBI University of Oslo
21855333 2 Ursolic acid is a PPAR-a agonist that regulates hepatic lipid metabolism.EBI Korea University
21889235 13 Discovery of gemfibrozil analogues that activate PPARa and enhance the expression of gene CPT1A involved in fatty acids catabolism.EBI Universit£ degli Studi G. d'Annunzio
21873070 29 SAR studies of acidic dual¿-secretase/PPAR¿ modulators.EBI Goethe-University Frankfurt
21514830 39 Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity.EBI The University of Tokyo
21450468 22 Revisiting glitazars: thiophene substituted oxazole containinga-ethoxy phenylpropanoic acid derivatives as highly potent PPARa/¿ dual agonists devoid of adverse effects in rodents.EBI Zydus Research Centre
21742490 8 Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARa antagonists.EBI Universit£ degli Studi G. d'Annunzio
20850970 27 Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.EBI Inha University
21557540 39 Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.EBI Pfizer Inc.
21482446 55 Discovery of new nanomolar peroxisome proliferator-activated receptor κ activators via elaborate ligand-based modeling.EBI Universiti Sains Malaysia
21344906 54 Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.EBI The University of Tokyo
19423341 6 Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.EBI Guiyang Medical College
21530275 42 Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists.EBI Okayama University
21515063 60 Biological evaluation of novel benzisoxazole derivatives as PPARd agonists.EBI Nippon Chemiphar Co. Ltd
21377875 19 Synthesis and pharmacological evaluation of novel benzoylazole-based PPARa/κ activators.EBI Dainippon Sumitomo Pharma Co, Ltd
21211969 42 Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.EBI USA.
21094606 24 Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists.EBI AstraZeneca R&D Charnwood
21130649 11 Development of a new class of benzoylpyrrole-based PPARa/¿ activators.EBI Dainippon Sumitomo Pharma Co, Ltd
21112784 15 Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation.EBI Nippon Chemiphar Co Ltd
21215640 21 Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.EBI Zydus Research Centre
21074432 25 Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo.EBI Seoul National University
21030263 5 1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPAR¿ partial agonists.EBI Sookmyung Women's University
20843696 12 Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR)d-selective partial agonists by disruption of molecular planarity/symmetry.EBI The University of Tokyo
20656494 11 Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.EBI Freie Universität Berlin
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
20503989 29 Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.EBI ZAFES/LiFF/Goethe University Frankfurt
20471839 4 Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARgamma ligands.EBI Universidade Federal de Pernambuco
20452212 26 Glycine amides as PPARalpha agonists.EBI Bayer-Schering Pharma
20356736 48 Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.EBI Bristol-Myers Squibb R&D
20347594 7 Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.EBI Goethe-University Frankfurt
20307981 16 Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.EBI Goethe-University Frankfurt
20218621 131 Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).EBI Bristol-Myers Squibb
19928766 425 Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.EBI The Genomics Institute of the Novartis Research Foundation
19853439 21 Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.EBI The University of Tokyo
20022492 29 Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARalpha agonists.EBI Zydus Research Centre
20079636 78 Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.EBI Centre de Recherches
19807106 11 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.EBI The University of Sydney
19791744 23 Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists.EBI Universit£ degli Studi G. d'Annunzio
19775169 41 New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.EBI Universit£ degli Studi di Bari
19556125 42 Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.EBI Goethe-University Frankfurt
19719236 23 Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation.EBI Wake Forest University
19376700 21 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.EBI UMR GICC
19530681 79 Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.EBI Merck Research Laboratories
 22 Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligandsEBI TBA
 4 Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1EBI TBA
 9 Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acidsEBI TBA
19507861 18 Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma aEBI Merck Research Laboratories
19379014 2 An innovative method to study target protein-drug interactions by mass spectrometry.EBI Martin-Luther-Universität Halle-Wittenberg
19349176 137 Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.EBI F. Hoffmann-La Roche Ltd
19301897 63 Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.EBI National Health Research Institutes
19275963 26 Selective, potent PPARgamma agonists with cyclopentenone core structure.EBI Universidade de Vigo
19201606 86 Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.EBI Bristol-Myers Squibb Research and Development
18947994 102 The discovery of equipotent PPARalpha/gamma dual activators.EBI Centre de Recherches
18835719 42 Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.EBI Università degli Studi di Bari
18821746 10 Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening.EBI University of Innsbruck
18809325 13 Analogues of 2-phenyl-ethenesulfonic acid phenyl ester have dual functions of inhibiting expression of inducible nitric oxide synthase and activating peroxisome proliferator-activated receptor gamma.EBI National Health Research Institutes
18805005 8 Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.EBI Zydus Research Centre
18771917 68 Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.EBI Yuhan Research Institute
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18665581 23 Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.EBI Vanderbilt University Center for Structural Biology
18662876 45 Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.EBI The University of Tokyo
18625559 16 Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.EBI Zydus Research Centre
18477507 1 Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.EBI Kyoto Pharmaceutical University
18329751 40 Synthesis and evaluation of a series of benzopyran derivatives as PPAR alpha/gamma agonists.EBI Graduate School of the Chinese Academy of Sciences
18321611 64 CoMFA analysis of dual/multiple PPAR activators.EBI National Institute of Pharmaceutical Education and Research
16643023 2 Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells.EBI University of Mississippi
11975517 3 Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.EBI Korea Research Institute of Bioscience and Biotechnology
18255290 28 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.EBI SPOT-EA3857
18060776 100 Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.EBI Centre de Recherches
18044841 12 Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation.EBI Boehringer Ingelheim Pharma GmbH & Co. KG
18029178 188 Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.EBI Eli Lilly and Company
18023179 58 Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.EBI Wyeth Pharmaceuticals
17624777 31 Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.EBI Korea Research Institute of Chemical Technology
17618115 1 Mycophenolic acid as a latent agonist of PPARgamma.EBI Hokkaido University
17601734 102 Indanylacetic acids as PPAR-delta activator insulin sensitizers.EBI Bayer Research Center
17574414 15 Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators.EBI National Institute of Pharmaceutical Education and Research
17553681 50 Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety.EBI RE&D VUFB, s.r.o.
17553678 97 Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.EBI Kowa Co.
17532641 57 Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.EBI University of Tokyo
17524643 14 Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.EBI Nagoya City University
17524639 73 Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.EBI Johnson and Johnson Pharmaceutical Research and Development
17512197 101 Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.EBI Pfizer Global Research and Development
17507225 34 Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists.EBI Seoul National University
17498950 69 Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists.EBI Pfizer Global Research and Development
17379517 45 Design of potent PPARalpha agonists.EBI Novo Nordisk A/S
17343371 27 Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.EBI Novo Nordisk A/S
17292606 91 Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17228882 9 Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.EBI Instituto de Química Médica
17157013 74 Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists.EBI Bayer Pharmaceuticals Corporation
17129725 90 Design and synthesis of a novel class of dual PPARgamma/delta agonists.EBI Lilly Research Laboratories
17034149 22 Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.EBI National Health Research Institutes
17005394 49 Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.EBI Eli Lilly and Co
16979341 59 Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.EBI Pfizer Global R&D
16973358 113 Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.EBI Pfizer Global R&D
16970391 88 Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.EBI Lilly Research Laboratories
16919947 30 Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.EBI Procter and Gamble Pharmaceuticals
16854085 11 Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.EBI Korea Research Institute of Chemical Technology
16797985 26 Studies towards the conception of new selective PPARbeta/delta ligands.EBI Université d'Orléans
16750626 51 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1.EBI The Genomics Institute of the Novartis Research Foundation
16737814 112 Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.EBI F. Hoffmann-La Roche Ltd
16640330 5 Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.EBI National Health Research Institutes
16546385 81 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.EBI The Genomics Institute of the Novartis Research Foundation
16529931 139 SAR studies: designing potent and selective LXR agonists.EBI Merck Research Laboratories
16451087 41 Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.EBI National Health Research Institutes
16384704 86 Design and synthesis of potent and subtype-selective PPARalpha agonists.EBI Merck Research Laboratories
16366601 82 Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.EBI National Health Research Institutes
16275080 174 Substituted indanylacetic acids as PPAR-alpha-gamma activators.EBI Bayer Research Center
16275077 27 Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.EBI University of Tokyo
16153845 81 Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists.EBI Merck Research Laboratories
16137885 59 Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs.EBI CNRS UMR 6052
16107159 106 Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.EBI Merck Research Laboratories
16107150 39 Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.EBI Università degli Studi di Milano
15974597 96 Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.EBI Merck Research Laboratories
15950464 146 (2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents.EBI Merck Research Laboratories
15863293 30 Selective PPARgamma modulators with improved pharmacological profiles.EBI Merck Research Laboratories
15801817 32 Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.EBI Merck Research Laboratories
15771468 19 Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15713415 13 Structure-activity relationships of dimeric PPAR agonists.EBI Novo Nordisk A/S
15603954 37 Benzoyl 2-methyl indoles as selective PPARgamma modulators.EBI Merck Research Laboratories
15582409 46 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.EBI Lilly Research Laboratories
15293980 47 Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.EBI GlaxoSmithKline
15177462 38 Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.EBI Research Institute of Tsinghua University
15163205 94 (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.EBI Merck Research Laboratories
15115385 68 Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.EBI Lilly Research Laboratories
14695833 46 Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.EBI Johnson and Johnson Pharmaceutical Research and Development
14613314 53 Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.EBI Division of Eli Lilly & Company
14592510 150 Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.EBI Ligand Pharmaceuticals Inc
14584939 32 Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.EBI Novo Nordisk A/S
14505666 99 Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists.EBI Merck Research Laboratories
12951082 10 Analysis of the critical structural determinant(s) of species-selective peroxisome proliferator-activated receptor alpha (PPAR alpha)-activation by phenylpropanoic acid-type PPAR alpha agonists.EBI Kyorin Pharmaceutical Co., Ltd.
12904063 69 Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.EBI Kyorin Pharmaceutical Co. Ltd.
12873517 90 5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.EBI Merck Research Laboratories
12729668 106 5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.EBI Merck Research Laboratories
12699745 49 Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.EBI GlaxoSmithKline
12672231 18 Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.EBI Novo Nordisk A/S
12657263 46 Phenylacetic acid derivatives as hPPAR agonists.EBI Merck Research Laboratories
12617924 140 Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.EBI Merck Research Laboratories
12482434 52 Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.EBI Novo Nordisk A/S
12443777 63 Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.EBI Biovitrum AB
11831892 46 Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.EBI Novo Nordisk A/S
11814790 8 Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.EBI Kyorin Pharmaceutical Co., Ltd.
11738577 19 Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.EBI Kyorin Pharmaceutical Co., Ltd.
11720854 48 Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.EBI GlaxoSmithKline
11677135 21 Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.EBI GlaxoSmithKline
11527737 70 Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.EBI GlaxoSmithKline
11405642 33 Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.EBI Lilly Research Laboratories
11354382 42 Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.EBI GlaxoSmithKline
10691680 72 The PPARs: from orphan receptors to drug discovery.EBI Glaxo Wellcome Research & Development
10612594 32 Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.EBI Glaxo Wellcome Research and Development
10508427 42 A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.EBI Glaxo Wellcome Research & Development
10098657 2 (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.EBI Kyorin Pharmaceutical Co., Ltd.
9934490 4 Differential activity of rosiglitazone enantiomers at PPAR gamma.EBI Glaxo Wellcome Research and Development
28485590 15 Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR?-Targeted Antidiabetics.EBI The Scripps Research Institute
20518620 16 Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors.BDB Université de Rennes 1
18394907 23 Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.BDB Pfizer
19827831 83 Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.BDB Novartis
19783444 28 Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.BDB Pfizer
19464171 87 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.BDB Amgen
18799592 17 Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.BDB Bristol-Myers Squibb Company
17157019 48 Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.BDB LG Life Sciences
16931011 36 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.BDB GNF
17403688 6 Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.BDB Consiglio Nazionale delle Ricerche
19053776 9 Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.BDB Consiglio Nazionale delle Ricerche
17608467 33 Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta.BDB Johnson & Johnson Pharmaceutical
17243659 72 Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.BDB GSK
18722772 105 Discovery of a novel class of PPARdelta partial agonists.BDB GSK
17274610 263 Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.BDB Bayer HealthCare Pharmaceuticals Corporation