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23 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26421921 43 Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.EBI Glenmark Research Centre
25815146 29 Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors.EBI Janssen Pharmaceutica NV
25495129 34 Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.EBI Janssen Pharmaceutica NV
24980052 37 Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.EBI Glenmark Pharmaceuticals Ltd
25221665 33 Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement.EBI Janssen Pharmaceutica NV
24758746 36 Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.EBI Janssen Pharmaceutica NV
24189054 2 PDE2 inhibition: potential for the treatment of cognitive disorders.EBI Dart Neuroscience LLC
23260348 91 Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.EBI Janssen-Cilag S.A.
22834877 119 Current landscape of phosphodiesterase 10A (PDE10A) inhibition.EBI Pfizer Inc
22548439 9 Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.EBI Amgen Inc
21777010 26 Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.EBI Janssen-Cilag S.A.
21705115 37 Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.EBI Washington University
21650160 19 Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.EBI Pfizer Inc
26597534 14 Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.EBI AstraZeneca
29574203 4 Inhibitors of phosphodiesterase as cancer therapeutics.EBI Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
19630403 19 Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been depoBDB Pfizer Inc
17228859 86 Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.BDB Pfizer Inc