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275 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28134521 8 Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.EBI Northeastern University
28109786 1 A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.EBI Tohoku Medical and Pharmaceutical University
28111140 24 Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.EBI East China Normal University
28189419 20 Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.EBI Tohoku Medical and Pharmaceutical University
27842892 18 Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and invitro evaluation as insulinomimetic and anti-inflammatory agents.EBI University of Messina
28202316 3 An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.EBI University of Arizona
28340988 9 Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.EBI Advinus Therapeutics Ltd
27526040 21 Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I.EBI Xi'an Jiaotong University
27336796 11 Sesquiterpene Hydroquinones with Protein Tyrosine Phosphatase 1B Inhibitory Activities from a Dysidea sp. Marine Sponge Collected in Okinawa.EBI Tohoku Medical and Pharmaceutical University
27142786 11 Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta.EBI Chinese Academy of Sciences
27123900 17 Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.EBI Qilu University of Technology
27353889 34 The design strategy of selective PTP1B inhibitors over TCPTP.EBI Chinese Academy of Sciences
26841168 9 Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.EBI Peking University
26961283 10 In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.EBI Universidad Aut£noma del Estado de Morelos
26965864 5 Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.EBI University of Lucknow
26774579 140 Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.EBI Shanghai Institute of Materia Medica
26704263 17 Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.EBI Qiqihar University
26711144 4 A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.EBI Tohoku Pharmaceutical University
26481657 20 Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.EBI Qilu University of Technology
26396684 15 Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.EBI University of Toronto Mississauga
26348881 54 Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.EBI National Health Research Institutes
26342135 39 Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.EBI Tianjin Medical University
26253631 8 Strongylophorines, new protein tyrosine phosphatase 1B inhibitors, from the marine sponge Strongylophora strongilata collected at Iriomote Island.EBI Tohoku Pharmaceutical University
26191366 66 Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.EBI Indiana University School of Medicine
26115570 4 Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.EBI Tohoku Pharmaceutical University
25264584 20 Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.EBI Universidad Aut£noma del estado de Morelos
25162754 2 Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.EBI The Ohio State University
26117648 5 Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.EBI University of Campinas
26100442 17 Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.EBI Qilu University of Technology
25907369 17 Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.EBI Catholic University of Daegu
25890697 6 Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.EBI Punjabi University
26083682 12 Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai.EBI Tohoku Pharmaceutical University
25835537 5 Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.EBI Chungnam National University
25938987 49 Is RK-682 a promiscuous enzyme inhibitor? Synthesis and invitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.EBI University of Campinas
25921264 21 Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.EBI Sanford-Burnham Medical Research Institute
25907367 6 Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.EBI Freie Universit£t Berlin
25907364 29 A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.EBI Indiana University
25703307 30 Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.EBI University of Pittsburgh
25638569 3 Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.EBI Guru Ghasidas Vishwavidyalaya (A Central University)
25891102 14 PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).EBI Chinese Academy of Sciences
25872983 57 Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.EBI Chinese Academy of Sciences
25819098 13 Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.EBI Toho University
25600405 7 Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.EBI Tohoku Pharmaceutical University
25595683 3 Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.EBI Tohoku Pharmaceutical University
25559759 12 Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.EBI Catholic University of Daegu
25124112 54 Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.EBI Liaoning Normal University
25064350 5 Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.EBI Chinese Academy of Sciences
25003231 59 Therapeutic potential of targeting the oncogenic SHP2 phosphatase.EBI Indiana University School of Medicine
24953600 35 Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.EBI Chonnam National University
24906513 21 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.EBI Chinese Academy of Sciences
25497963 19 Bioactive constituents from the green alga Caulerpa racemosa.EBI Nanchang University
25453820 2 Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities.EBI Wonkwang University
25372368 58 Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.EBI Shandong University
24840014 25 Ingol-type diterpenes from Euphorbia antiquorum with mouse 11-hydroxysteroid dehydrogenase type 1 inhibition activity.EBI Lanzhou University
24593120 5 Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.EBI Chinese Academy of Sciences
24721313 21 Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.EBI Northwest University
24287560 61 Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.EBI University of Messina
24224843 11 Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.EBI Chosun University
24185377 6 Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.EBI School of Pharmaceutical Sciences
24148325 8 Discovery of novel PTP1B inhibitors via pharmacophore-oriented scaffold hopping from Ertiprotafib.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
24090912 54 Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.EBI Chinese Academy of Sciences
24047800 19 Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.EBI Toho University
24012179 30 Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.EBI National Academy of Sciences of Ukraine
23957426 14 Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).EBI Case Western Reserve University
23942421 43 The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.EBI Chinese Academy of Sciences
23859780 5 Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.EBI Chinese Academy of Sciences
23713581 75 A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.EBI Indiana University School of Medicine
23644196 3 Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice.EBI Chinese Academy of Sciences
23531458 6 Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.EBI Northwest University
23528300 48 Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.EBI Aurigene Discovery Technologies Limited
23499238 15 Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
23434422 2 Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.EBI Tohoku Pharmaceutical University
23387824 18 Sesquiterpenes from the rhizomes of Curcuma heyneana.EBI University of Toyama
23357636 4 Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.EBI Chinese Academy of Sciences
23305444 171 Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.EBI Indiana University School of Medicine
23177789 16 Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.EBI Shenyang Pharmaceutical University
20452766 96 Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.EBI Tsinghua University
19385614 303 Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.EBI Abbott Laboratories
15537353 59 Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.EBI Leadscope, Inc.
14561096 16 Finding discriminating structural features by reassembling common building blocks.EBI Leadscope, Inc.
22546204 9 Recent developments and biological activities of thiazolidinone derivatives: a review.EBI Dr. Hari Singh Gour University
23141910 2 New diterpene furanoids from the Antarctic lichen Huea sp.EBI Silla University
23141909 46 Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.EBI Universit£ Paris Descartes
23122867 27 7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors.EBI Roche Research Center
23122522 25 Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.EBI East China University of Science and Technology
23067554 37 Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.EBI East China Normal University
22341243 6 Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.EBI Central Drug Research Institute
23022281 7 New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.EBI Chosun University
21988196 15 Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents.EBI University of Messina
21453996 20 Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.EBI Universidad Aut£noma del Estado de Morelos
23043764 70 Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.EBI Shanghai Jiao Tong University
22940448 8 Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.EBI Yeungnam University
22690646 6 Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
22506091 151 Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.EBI TBA
22705189 24 Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.EBI Imperial College London
22583779 6 Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.EBI Universidad Aut£noma del Estado de Morelos
22444684 9 Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.EBI Chinese Academy of Sciences
22424978 23 Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.EBI Advinus Therapeutics Ltd
22381357 41 New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.EBI University of Messina
22133902 9 Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.EBI Indiana University
20724155 7 Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.EBI Toho University
20462762 19 Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.EBI Universidade Federal de Santa Catarina
19836230 17 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.EBI Chosun University
20153651 37 Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.EBI Chinese Academy of Sciences
19846295 8 Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.EBI Korea Research Institute of Bioscience and Biotechnology
19632832 15 Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.EBI Institute
19269068 11 Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.EBI Sejong University
19362837 10 Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.EBI Silla University
19008110 18 Flavanones from the stem bark of Erythrina abyssinica.EBI Korea Research Institute of Bioscience and Biotechnology (KRIBB)
18798681 17 Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.EBI Chosun University
18993066 12 Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors.EBI CNRS
18555687 14 A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.EBI University of Waterloo
17125223 15 Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.EBI Korea Research Institute of Bioscience and Biotechnology
18288807 5 Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum.EBI Silla University
18056643 8 Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.EBI Indiana University School of Medicine
18372175 45 PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.EBI Affymax, Inc.
18053716 6 Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.EBI Silla University
18477508 39 Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.EBI Merck Frosst Centre for Therapeutic Research
17728130 36 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.EBI Inha University
17543532 46 5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.EBI Universit£ di Messina
17596944 10 Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors.EBI Yonsei University
17368023 24 Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.EBI Inha University
17489632 15 Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.EBI Korea Research Institute of Bioscience and Biotechnology
16545563 9 Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.EBI Korea Research Institute of Bioscience and Biotechnology
16580200 13 Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.EBI Korea Research Institute of Bioscience and Biotechnology
15380203 3 Development of a polyvalent assay system for lead identification.EBI Wyeth Research
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
12014959 11 Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.EBI Pfizer Inc.
11741477 37 Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.EBI University of Waterloo
9379439 16 A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.EBI University of California
15050628 26 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.EBI Inha University
11814804 9 The first two cantharidin analogues displaying PP1 selectivity.EBI The University of Newcastle
12419386 5 Synthesis of [difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B.EBI University of Waterloo
11677131 42 Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.EBI The University of Newcastle
10743947 12 Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors.EBI New York University
9871682 19 Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.EBI University of Toronto
 7 The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects.EBI TBA
22318165 85 Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.EBI Shanxi University
22136336 55 Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).EBI Universidade Federal de Santa Catarina
22189136 25 Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.EBI M.S. University of Baroda
22197396 57 Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.EBI Kyoto Pharmaceutical Industries
22044245 4 Cucurbitane glucosides from the root of Machilus yaoshansis.EBI State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine
21882820 72 Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.EBI Bristol-Myers Squibb Research and Development
21745700 20 Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.EBI East China University of Science and Technology
21680062 77 Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.EBI Yanbian University
21571537 14 New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.EBI Chosun University
20850970 27 Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.EBI Inha University
21669525 18 Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.EBI Indiana University
21696953 3 Pyrrolo[2,3-c]azepine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.EBI Sun Yat-Sen University
21665482 62 Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.EBI East China University of Science and Technology
19500993 42 Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.EBI Central Drug Research Institute
21548579 4 Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne.EBI Second Military Medical University
21555221 44 Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.EBI Chonnam National University
21443195 9 Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.EBI NCI-Frederick
21420867 68 Using small molecules to target protein phosphatases.EBI Max-Planck-Institute of Molecular Physiology
21251827 60 A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.EBI East China University of Science and Technology
21190368 60 Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.EBI Sanford-Burnham Medical Research Institute
21193311 22 Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.EBI H. Lee Moffitt Cancer Center and Research Institute
20964318 4 Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.EBI Xihua University
20731359 29 A focused library of protein tyrosine phosphatase inhibitors.EBI Brown University
20627471 54 Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.EBI Glenmark Research Center
20806783 2 Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.EBI University of Vienna
20472439 37 Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.EBI Chinese Academy of Sciences
20471838 9 Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.EBI Central Drug Research Institute
20363629 49 Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.EBI Chinese Academy of Sciences
19889539 49 Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.EBI University of California
19811915 11 Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents.EBI Central Drug Research Institute
19782562 10 Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.EBI Silla University
19702283 1 Chemical Constituents of the Roots of Euphorbia micractina.EBI Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine
19476336 4 Chemical constituents from the aerial parts of Artemisia minor.EBI Chinese Academy of Sciences
20000419 51 Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.EBI Incyte Corporation
20170098 21 Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).EBI Indiana University School of Medicine
19888758 55 Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.EBI Institute for Medical Research
19846303 59 Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.EBI East China Normal University
19810703 102 Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.EBI University of Miami
19783142 27 Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.EBI Inha University
19500977 20 Structure-based virtual screening approach to identify novel classes of Cdc25B phosphatase inhibitors.EBI Sejong University
19349096 81 Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.EBI Glenmark Research Center
 75 Synthesis and phosphatase inhibitory activity of analogs of sulfircinEBI TBA
19362487 4 Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.EBI Universidad Autónoma del Estado de Morelos
19303291 4 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.EBI Central Drug Research Institute
19297174 41 Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.EBI University of Modena and R.E.
19282172 3 Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.EBI Central Drug Research Institute
19217304 44 5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.EBI University of Messina
19091557 2 A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.EBI Chinese Academy of Sciences
18922697 5 Synthesis of triazole-linked beta-C-glycosyl dimers as inhibitors of PTP1B.EBI CNRS
18722777 37 Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.EBI Inha University
18707891 152 Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.EBI Chinese Academy of Sciences
18595691 1 Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.EBI University of Missouri-Columbia
18579388 18 Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.EBI Chinese Academy of Sciences
18436346 28 Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.EBI Central Drug Research Institute
17897956 3 Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling.EBI University of California
18037290 66 Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.EBI Incyte Corporation
17949055 2 Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors.EBI Griffith University
17931864 18 2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.EBI Heriot-Watt University
17705360 76 Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.EBI Wyeth Research
17692525 33 Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.EBI Inha University
17517504 6 Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B.EBI Korea Research Institute of Bioscience and Biotechnology
17407812 2 PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta).EBI Inha University
17394300 35 Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.EBI Institute for Medical Research
17336064 44 Probing acid replacements of thiophene PTP1B inhibitors.EBI Wyeth Research
17279797 2 Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.EBI Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine
17249650 1 Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug.EBI Purdue University
17095232 20 Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors.EBI Central Drug Research Institute
16884299 18 Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.EBI University of Bonn
16789735 57 Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.EBI Incyte Corporation
16759857 59 Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.EBI Procter & Gamble Pharmaceuticals
16716588 9 A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.EBI Amherst College
16563751 1 Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia.EBI Chinese Academy of Sciences
16460930 10 Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors.EBI Central Drug Research Institute
16434190 48 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.EBI Graduate School of Chinese Academy of Sciences
16356713 14 Protein tyrosine phosphatase 1B inhibitors from Morus root bark.EBI Korea Research Institute of Bioscience and Biotechnology (KRIBB)
16289879 34 PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.EBI Korea Research Institute of Chemical Technology
16236508 35 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.EBI Technische Universität München
16220970 7 Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.EBI Incyte Corporation
16046123 41 Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.EBI Affymax, Inc.
16039123 32 Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.EBI NIH
15863305 5 Structure-based design of protein tyrosine phosphatase-1B inhibitors.EBI AstraZeneca
15293983 3 Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs.EBI Serono Pharmaceutical Research Institute
15013020 94 Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.EBI Merck Frosst Centre for Therapeutic Research
15013019 47 The development of potent non-peptidic PTP-1B inhibitors.EBI Merck Frosst Centre for Therapeutic Research
14611852 34 Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.EBI Roche Research Center
13678400 9 Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.EBI Abbott Laboratories
12951078 38 Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.EBI Abbott Laboratories
12941322 12 Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.EBI NIH
12877578 33 Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.EBI Abbott Laboratories
12852970 28 Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.EBI National Cancer Institute
12852966 23 Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.EBI Inha University
12617932 10 Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity.EBI Pharmacia Corporation
12419367 5 Natural PTP1B inhibitors from Broussonetia papyrifera.EBI Chinese Academy of Sciences
12372498 23 alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.EBI The Ohio State University
12238924 145 Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.EBI Novo Nordisk A/S
12190316 15 Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.EBI Brown University
12113814 60 Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.EBI Korea Research Institute of Chemical Technology
11960490 3 Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.EBI Biovitrum AB
11708908 55 Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.EBI University of Pittsburgh
11520195 19 Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.EBI National Cancer Institute
11459664 21 alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.EBI Brown University
11356112 175 Potent reversible inhibitors of the protein tyrosine phosphatase CD45.EBI AstraZeneca Pharmaceuticals
11212099 107 Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.EBI University of Pittsburgh
11128645 16 Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.EBI Taisho Pharmaceutical Co., Ltd
10915044 4 Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes.EBI Wyeth-Ayerst Research
10853661 25 Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.EBI National Cancer Institute
10753467 118 Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.EBI Wyeth-Ayerst Research
10715163 35 New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.EBI Wyeth-Ayerst Research
10464006 22 PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.EBI Wyeth-Ayerst Research
10098656 13 Synthesis and biological evaluation of alpha,alpha-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B.EBI Tokyo University of Pharmacy & Life Science
10091683 12 Periodinates: a new class of protein tyrosine phosphatase inhibitors.EBI McGill University
9873717 12 Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.EBI University of Toronto
9873503 4 Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).EBI National Cancer Institute
8676336 2 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.EBI National Cancer Institute
23009604 17 Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.BDB Yanbian University College of Pharmacy
28569147 21 Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.BDB Concordia University of Wisconsin
 42 Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activitiesBDB Catholic University of Daegu
 8 PTP1B inhibitors from Selaginella tamariscina (Beauv.) Spring and their kinetic properties and molecular docking simulationBDB Catholic University of Daegu
28126289 11 Synthesis, biological evaluation and in silico studies of 5-(3-methoxybenzylidene)thiazolidine-2,4-dione analogues as PTP1B inhibitors.BDB Panjab University
25996453 4 Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.BDB Jiangnan University
22083916 65 Synthesis of (glycopyranosyl-triazolyl)-purines and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B).BDB East China University of Science and Technology
22864521 25 Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B.BDB Shanxi University
24752625 25 Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.BDB Lanzhou University
24684845 35 Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.BDB Jiangnan University
21111404 19 Preparation of triazole-linked glycosylated ??????-ketocarboxylic acid derivatives as new PTP1B inhibitors.BDB East China University of Science and Technology
21506278 23 Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.BDB Zydus Research Centre
23848232 24 Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.BDB Tianjin Medical University
 10 Synthesis of 3,5-disubstituted isoxazolines as protein tyrosine phosphatase 1B inhibitorsBDB Central Drug Research Institute,
17191286 23 Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.BDB McGill University
15515092 54 The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors.BDB Max-Planck-Institut für Kohlenforschung
18680359 66 Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.BDB Moffitt Cancer Center