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78 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26898814 154 SAR exploration at the C-3 position of tetrahydro--carboline sstr3 antagonists.EBI Merck Research Laboratories
26005524 147 Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.EBI Merck Research Laboratories
25699156 24 Treating pain with somatostatin receptor subtype 4 agonists.EBI Therachem Research Medilab (India) Pvt. Ltd.
25050159 71 Investigation of Cardiovascular Effects of Tetrahydro--carboline sstr3 antagonists.EBI Merck Research Laboratories
24944745 75 Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.EBI Merck Research Laboratories
18162395 89 Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.EBI Novartis Institutes for BioMedical Research
17512199 110 SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.EBI Novartis Institutes for BioMedical Research
17507221 58 Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.EBI Novartis Institutes for BioMedical Research
24900499 67 The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.EBI TBA
24900466 55 Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.EBI TBA
24900340 40 N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.EBI TBA
20666484 40 Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors.EBI University of Firenze
19351180 165 Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.EBI The Clayton Foundation Laboratories for Peptide Biology
19067538 110 Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.EBI Vrije Universiteit Brussel
18543899 171 Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.EBI University of Berne
18410084 115 Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.EBI Salk Institute
18410083 30 Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.EBI Salk Institute
18210999 21 Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.EBI University of Firenze
16220980 43 Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells.EBI University of California San Diego
15828816 100 N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo.EBI Technische Universit£t M£nchen
15658865 240 Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.EBI Salk Institute
15982879 61 3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists.EBI Institut Henri Beaufour
14667213 90 Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.EBI Salk Institute
14667212 110 Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.EBI Salk Institute
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI Merck Research Laboratories
11312929 90 Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.EBI Tulane University Health Sciences Center
11520208 45 Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.EBI Institut Henri Beaufour
9544214 197 Potent antagonists of somatostatin: synthesis and biology.EBI Tulane University School of Medicine
9632348 37 Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.EBI Merck Research Laboratories
11327607 67 Novel non-peptide ligands for the somatostatin sst3 receptor.EBI Institut Henri Beaufour
11266182 53 Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.EBI Institut Henri Beaufour
21806016 78 N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.EBI Salk Institute
20684600 53 Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.EBI Alchemia Ltd
19786348 261 Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.EBI F. Hoffmann-La Roche Inc
18020391 12 From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.EBI F. Hoffmann-La Roche Inc
18020390 37 Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.EBI F. Hoffmann-La Roche Inc
17559206 22 New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold.EBI Vrije Universiteit Brussel
16854054 30 Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.EBI Salk Institute
15658864 225 Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan.EBI Salk Institute
14667215 64 Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.EBI Salk Institute
14667214 185 Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.EBI Salk Institute
11931620 40 Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units.EBI Hebrew University
11405660 155 Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).EBI Salk Institute
11311064 84 N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity.EBI Tulane University Health Sciences Center
11133079 10 Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation.EBI University of California
10354394 216 Highly potent cyclic disulfide antagonists of somatostatin.EBI Tulane University School of Medicine
10091708 32 Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.EBI Merck Research Laboratories
9667958 40 Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.EBI University of California San Diego
9554871 43 Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.EBI University of Pennsylvania
24378707 45 [DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.EBI INRASTES
24342240 20 A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity.EBI Institute for Research in Biomedicine (IRB Barcelona)
12773038 130 A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.EBI Novartis Pharma
11448228 25 Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4.EBI ETH Zurich
30429949 59 Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.EBI Merck & Co.
28988629 28 Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.EBI Takeda Pharmaceutical Company Limited
11095748 54 SST3-selective potent peptidic somatostatin receptor antagonists.BDB University of Berne
10818260 13 Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806.BDB University of Cambridge
10598788 305 Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.BDB Novartis Pharma AG
10433861 79 Somatostatin and its receptor family.BDB Royal Victoria Hospital
9724791 24 Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.BDB Merck Research Laboratories
9650799 159 [125I]Tyr10-cortistatin14 labels all five somatostatin receptors.BDB Novartis Pharma AG
9600011 111 The elucidation of somatostatin receptor functions: a current view.BDB German Institute of Human Nutrition
9290757 14 The somatostatin analog octreotide as potential treatment for re-stenosis and chronic rejection.BDB Novartis Pharma Research
9166718 19 Differential expression of multiple somatostatin receptors in the rat cerebellum during development.BDB Dynamique des Systemes Neuroendocriniens
9045884 44 Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.BDB Cedars-Sinai Research Institute
8863814 21 Identification and characterization of novel somatostatin antagonists.BDB Cyenamid Agricultural Research Center
8769372 74 Binding properties of somatostatin receptor subtypes.BDB Sandoz Pharma Ltd
8521788 22 Molecular biology of somatostatin receptors.BDB University of Pennsylvania
8100350 137 Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.BDB University of Pennsylvania
7988476 136 Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).BDB McGill University
7870182 115 Molecular pharmacology of somatostatin receptors.BDB Sandoz Pharma Ltd
7535424 29 Characterization of somatostatin receptor subtypes controlling rat gastric acid and pancreatic amylase release.BDB Tulane University
1328199 8 Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.BDB University of Chicago