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337 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28244748 119 The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.EBI Virginia Commonwealth University
8258822 102 Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.EBI University of Georgia
2153822 77 1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor.EBI Syntex Research
27639363 141 Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.EBI Huazhong University of Science and Technology
26390077 42 Tactical Approaches to Interconverting GPCR Agonists and Antagonists.EBI University of Minnesota
26820556 156 Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.EBI Dipartimento di Farmacia Universit£ di Napoli"Federico II"
26483200 100 Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.EBI Huazhong University of Science and Technology
25076379 87 Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.EBI Shanghai Institute of Materia Medica (SIMM)
26023814 79 Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.EBI IQM-CSIC
25936259 55 Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.EBI Jagiellonian University Medical College
25965777 58 Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.EBI Jagiellonian University Medical College
25759032 55 Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands.EBI Universit£ di Catania
25630223 5 Target engagement in lead generation.EBI Eli Lilly and Company
25461308 64 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4.EBI Medical University of Warsaw
25435254 82 Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.EBI Jagiellonian University Medical College
24900840 35 Enhancing a CH-? Interaction to Increase the Affinity for 5-HT1A Receptors.EBI University of Li£ge
24618300 28 Synthesis and biological evaluation of a series of benzoxazole/benzothiazole-containing 2,3-dihydrobenzo[b][1,4]dioxine derivatives as potential antidepressants.EBI Huazhong University of Science and Technology
23353740 21 Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.EBI Universidade Federal de Goi£s
23218776 45 Discovery of novela1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.EBI H. Lundbeck A/S
11462977 21 Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.EBI University of Bologna
3373482 50 Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.EBI Merrell Dow Research Institute
20934789 27 Synthesis anda1-adrenoceptor antagonist activity of tamsulosin analogues.EBI Universit£ di Camerino
20813529 48 Search for influence of spatial properties on affinity ata1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.EBI Jagiellonian University Medical College
19447527 2 Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity.EBI Jagiellonian University Medical College
19719240 25 Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity.EBI University of Camerino
17276073 11 Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin.EBI University of Camerino
17125266 72 WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).EBI Universit£ degli Studi di Milano
15633998 18 Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.EBI University of Bologna
12672251 9 1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.EBI Universit£ degli Studi di Modena e Reggio Emilia
11931617 36 Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.EBI University of Camerino
10737740 57 Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.EBI Freie Universit£t Berlin
9822553 63 Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.EBI University of Bologna
11454468 35 Discovery and SAR of org 24598-a selective glycine uptake inhibitor.EBI Organon Research and Development Group
9873561 29 Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.EBI Solvay Pharma
22386241 46 Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.EBI SK Biopharmaceuticals
21549456 10 Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties.EBI Universidade Federal do Rio de Janeiro
23124215 72 Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selectivea1B-adrenoceptor antagonist.EBI Universit£ di Milano
21816515 93 Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.EBI Medical University of Warsaw
20153652 49 Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.EBI Universidade Federal do Rio Grande do Sul
19831400 47 Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.EBI European Research Centre for Drug Discovery and Development
19560916 39 Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.EBI Jagiellonian University Medical College
18603331 73 The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.EBI Jagiellonian University Medical College
19053780 76 Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.EBI Universita degli Studi di Bari
18760923 37 Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists.EBI Universit£ degli Studi di Perugia
18361484 61 (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.EBI EGIS Pharmaceuticals Plc
17228858 236 Advances in development of dopaminergic aporphinoids.EBI Chinese Academy of Sciences
17517514 63 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.EBI Jagiellonian University Medical College
15801844 25 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI Universidad Complutense
15914001 16 New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects.EBI Daiichi Suntory Biomedical Research Co., Ltd
14640559 405 Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.EBI FAES FARMA S A
12519065 243 Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.EBI H. Lundbeck A/S
12930145 77 Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.EBI Universit£ di Siena
12477356 137 Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.EBI Universit£ degli Studi di Bari
12361392 62 Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.EBI Universit£ degli Studi di Sassari
11170629 35 Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.EBI Universidad Complutense
11170628 37 Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.EBI Universidad Complutense
10956195 38 Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).EBI University Centre for Pharmacy
10229626 66 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.EBI Universit£ di Siena
10090790 131 Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs.EBI Taisho Pharmaceutical Company, Ltd.
10602693 64 Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents.EBI Wyeth-Ayerst Research
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI Universit£ di Siena
9703460 52 Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.EBI National Taiwan University
9622541 97 Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.EBI R. W. Johnson Pharmaceutical Research Institute
9599242 23 (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.EBI Astra Arcus AB
9135028 114 Pharmacological options in the treatment of benign prostatic hyperplasia.EBI Pfizer Central Research
9111299 25 N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor.EBI Yamanouchi Pharmaceutical Company, Ltd.
9083484 84 New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.EBI Cooperation Pharmaceutique Fran�aise
9435894 206 New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.EBI Wyeth-Ayerst Research Laboratories
9357534 49 Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.EBI Universit£ di Siena
9171874 50 Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.EBI Universidad Complutense
8691479 24 trans-2-Aryl-N,N-dipropylcyclopropylamines: synthesis and interactions with 5-HT(1A) receptors.EBI Uppsala University
8676355 90 Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents.EBI Glaxo Wellcome Inc.
8960552 58 Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.EBI Universit£ di Bari
8863803 22 Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.EBI Universit£ di Bari
8831770 136 Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.EBI Hoechst Marion Roussel, Inc.
8831769 42 Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.EBI Uppsala University
8759642 53 1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.EBI Universit£ di Bari
8568804 42 New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.EBI Universit£ di Bari
7473548 74 N-aryl-N'-benzylpiperazines as potential antipsychotic agents.EBI R.W. Johnson Pharmaceutical Research Institute
7473547 103 Piperazinylalkyl heterocycles as potential antipsychotic agents.EBI R. W. Johnson Pharmaceutical Research Institute
7629808 64 Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.EBI Universit£ di Siena
7783153 189 Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology.EBI Upjohn Laboratories
7783131 78 Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.EBI H. Lundbeck A/S
7799409 20 Derivatives of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl-p-iodobenzamido)ethyl]pipera zine (p-MPPI) as 5-HT1A ligands.EBI University of Pennsylvania
8064803 43 Structure-affinity relationship studies on 5-HT1A receptor ligands. 2. Heterobicyclic phenylpiperazines with N4-aralkyl substituents.EBI Solvay Duphar Research Laboratories
8064801 232 Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.EBI University of G£teborg
7912735 270 3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.EBI Universit£ d'Orl£ans
8182697 11 Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.EBI University of Pennsylvania
8289183 24 Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.EBI Abbott Laboratories
7902439 31 (R)-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines: novel optically active compounds with strong 5-HT1A receptor binding ability exhibiting anticonflict activity and lessening of memory impairment.EBI Asahi Chemical Industry Company, Ltd.
8230131 25 Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo.EBI Medicinaregatan
8230102 21 Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.EBI University of Pennsylvania
1346653 168 Pyrrole mannich bases as potential antipsychotic agents.EBI R. W. Johnson Pharmaceutical Research Institute
1361578 99 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI Bristol-Myers Squibb Co.
1908521 106 Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.EBI Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer
1672156 81 Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.EBI Hoechst-Roussel Pharmaceuticals, Inc.
1995871 25 A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin.EBI Uppsala University
1833546 47 Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.EBI Abbott Laboratories
2258903 23 Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.EBI Lilly Research Laboratories
2569041 8 5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.EBI College of Pharmacy University of Iowa
2542551 89 The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.EBI Bristol-Myers Company
2565399 25 Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents.EBI Wyeth-Ayerst Research
2539480 50 Design and synthesis of propranolol analogues as serotonergic agents.EBI Virginia Commonwealth University
2571729 15 Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.EBI University of G£teborg
2898533 50 Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.EBI Wyeth-Ayerst Research
2967376 13 Central dopaminergic and 5-hydroxytryptaminergic effects of C3-methylated derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.EBI University of Uppsala
3543362 184 Central serotonin receptors as targets for drug research.EBI TBA
11354357 61 Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.EBI Abbott Laboratories
11078200 61 N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists.EBI Welfide Corporation
9873481 80 SAR of novel biarylmethylamine dopamine D4 receptor ligands.EBI Darmstadt
22277589 72 Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.EBI Jagiellonian University Medical College
22133459 56 New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.EBI Universit£ di Napoli"Federico II"
22029386 156 New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.EBI Universidad Complutense de Madrid
22001327 77 Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.EBI Jagiellonian University Medical College
21859099 57 Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT7 receptor antagonist activity.EBI EGIS Pharmaceuticals Plc.
21802308 29 Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for thea1-adrenoceptors.EBI Universit£ degli Studi di Catania
21601317 47 Synthesis and structural investigation of some pyrimido[5,4-c]quinolin-4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT(1A/2A) and 5-HT(7) receptor ligands.EBI Medical University of Lodz
21440338 36 Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents.EBI Universit£ di Napoli Federico II
21093118 32 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3.EBI Medical University of Warsaw
20857909 176 Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity fora(1)-adrenoceptors.EBI University of Copenhagen
20481570 81 Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.EBI Universita di Siena
20363131 4 Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.EBI Universidade Federal de Goi£s
20347301 32 New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation.EBI Universit£ di Napoli Federico II
20060623 30 Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity.EBI Jagiellonian University Medical College
20138771 34 SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling.EBI Universit£ d'Orl£ans
19679379 33 Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.EBI Jagiellonian University Medical College
19665823 38 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.EBI Medical University of Warsaw
19954866 31 Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.EBI Universit£ di Napoli
 49 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI TBA
 52 Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.EBI TBA
 48 Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligandsEBI TBA
 53 5-HT1A and 5-HT2A ligands with anxiolytic and antipanic-like propertiesEBI TBA
 12 The synthesis and evaluation of the major metabolites of mazapertineEBI TBA
 21 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonistsEBI TBA
 43 2-[4-(o-methoxyphenyl)piperazin-1-ylmethyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine as a new selective 5-HT1A receptor ligandEBI TBA
 58 Synthesis and serotonin receptor binding properties of 5-substituted 3-(1′,2′,5′,6′-tetrahydropyridin-3′-yl) indolesEBI TBA
 12 5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl] benzimidazole (CP-161,242): A potent, centrally active 5-HT1D receptor agonist and benzodiazepine partial agonistEBI TBA
 34 Bivalent indoles exhibiting serotonergic binding affinityEBI TBA
 68 N-(2-pyrrolidinylmethyl)benzoxazine-8-carboxamides exhibiting high affinities for All of D2, 5-HT1 A, and 5-HT2 receptorsEBI TBA
 25 Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic propertiesEBI TBA
 50 Synthesis and evaluation of n-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives as potential anti-ischemic agentsEBI TBA
 29 Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profileEBI TBA
 17 C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT1A-receptorsEBI TBA
19425598 61 Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.EBI European Research Centre for Drug Discovery and Development
19072656 110 Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.EBI University of Siena
18995929 24 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.EBI Medical University of Warsaw
18835172 19 Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.EBI Chinese Academy of Sciences
18783955 35 N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.EBI Chinese Academy of Sciences
18644726 36 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.EBI Institut für Interdisziplinäre Isotopenforschung
18598015 53 Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.EBI Università di Catania
18585036 18 Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines.EBI Harvard Medical School
18562201 13 Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.EBI Chinese Academy of Sciences
18487050 36 Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.EBI Hadassah-Hebrew University Hospital
18486277 58 Synthesis and serotonin receptor activity of the arylpiperazine alkyl/propoxy derivatives of new azatricycloundecanes.EBI Institute of Pharmacology of the Polish Academy of Sciences
17900912 15 1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.EBI Università di Milano
17543523 17 R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.EBI Harvard Medical School
17419056 16 Novel aminoethylbiphenyls as 5-HT7 receptor ligands.EBI Université de Caen
17321139 48 Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.EBI Université Montpellier I et II
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16686532 27 NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.EBI Università degli Studi di Torino
16545955 16 New 4-(4-methyl-phenyl)phthalazin-1(2H)-one derivatives and their effects on alpha1-receptors.EBI Università degli Studi di Perugia
16513345 45 Vasorelaxant activity of phthalazinones and related compounds.EBI Universidad de Salamanca
16275073 16 Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids.EBI Universidad de Santiago de Compostela
16250661 13 11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.EBI University of Milano/Bicocca
16219465 82 Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.EBI Abbott GmbH & Co. KG
16107148 44 New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.EBI Università di Napoli "Federico II"
16055331 45 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.EBI Carlsson Research AB
16002287 9 Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.EBI Université de Caen
15801833 35 Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.EBI Università di Catania
15588097 95 Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.EBI Università degli Studi di Bari
15501057 20 The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.EBI Polish Academy of Sciences
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15341483 110 Indolebutylamines as selective 5-HT(1A) agonists.EBI Merck KGaA
15267230 50 Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists.EBI Uppsala University
15115407 8 New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.EBI Collegium Medicum of the Jagiellonian University
15055991 265 Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.EBI Recordati s.p.a.
12951088 22 Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.EBI Universidad Complutense
12877594 14 Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.EBI Università di Pisa
12668005 21 Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI Universidad Complutense
12570387 60 Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI Università degli Studi di Bari
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12482417 23 alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.EBI Università di Pisa
12238918 22 N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.EBI Abbott Laboratories
12213056 42 Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.EBI Universidad de Navarra
12166933 24 Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.EBI Università di Pisa
11934576 85 Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.EBI Université de Lille 2
11741489 45 Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.EBI Pharmacia
11728188 53 trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.EBI Università Bari
11689074 112 N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.EBI Merck Sharp & Dohme Research Laboratories
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI Universidad de Navarra
11384242 126 Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.EBI Abbott Laboratories
11354383 24 Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.EBI Polish Academy of Sciences
11229779 11 New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects.EBI Suntory Biomedical Research Limited
11212112 24 Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.EBI Uppsala University
11101361 37 Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.EBI Purdue University
10956192 31 Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor.EBI AstraZeneca R&D Södertälje
10956183 19 De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.EBI Synaptic Pharmaceutical Corporation
10853650 36 Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity.EBI Yoshitomi Pharmaceutical Industries, Ltd.
10843224 28 High potent and selective arylpiperazine derivatives as ligands for the 5-HT1A receptor.EBI Università di Catania
10780916 134 Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).EBI Abbott Laboratories
10753471 64 Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.EBI Uppsala University
10743959 48 N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.EBI Yoshitomi Pharmaceutical Industries, Ltd.
10737747 54 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.EBI Merck KGaA
10669578 44 New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.EBI University of Groningen
10669570 8 Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.EBI University of Groningen
10649982 54 A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.EBI Universitá di Bari
10636243 6 Synthesis and binding studies of some epibatidine analogues.EBI Institute of Pharmacy and Biochemistry
10585205 10 On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.EBI Polish Academy of Sciences
10476865 2 Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.EBI Universidad Complutense
10464021 59 N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI Knoll Pharmaceuticals
10386940 31 Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.EBI Uppsala University
10360740 35 N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.EBI POSTECH
10354409 131 New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.EBI Wyeth-Ayerst Research Laboratories
10090793 12 Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine.EBI Purdue University
9986719 39 1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.EBI Università di Bari
9986714 105 Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists.EBI Recordati S.p.A.
9934472 12 Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors.EBI University of Vigo
9888842 21 Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.EBI Università di Milano
9888831 83 Synthesis and structure-activity relationships of a new model of arylpiperazines. 4. 1-[omega-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene) - 2, 5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2, 5-pyrrolidinediones: study of the steric requirements of the terminal amide fragment on 5-HT1A aEBI Universidad Complutense
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI Centro de Investigación Grupo Ferrer
9873563 67 Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.EBI Merck & Co.
9871719 144 Serotonergic ergoline derivatives.EBI Pharmacia & Upjohn S.p.A.-CNS Research
9871564 60 1-[omega-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5- pyrrolidinediones as 5-HT1A receptor ligands: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.EBI Universidad Complutense
9836624 64 Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding.EBI Virginia Commonwealth University
9836617 30 Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives.EBI Purdue University
9822559 47 N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.EBI Universitá di Bari
9667967 65 Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.EBI Yamanouchi Pharmaceutical Company, Ltd.
9622555 25 Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.EBI Purdue University
9548811 55 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.EBI Merck & Co.
9513604 76 Aminopyrimidines with high affinity for both serotonin and dopamine receptors.EBI Warner-Lambert Company
9457239 18 Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands.EBI University of Pennsylvania
9379432 36 Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prEBI Abbott Laboratories
9301661 32 Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.EBI Purdue University
9276014 62 Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.EBI Warner-Lambert Company
9258372 40 Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment on 5-HT1A affinity/selectivity.EBI Universidad Complutense
9046348 45 [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.EBI Università di Catania
9022796 57 5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.EBI Solvay Pharma
8893838 106 Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.EBI Universidad Complutense
8893836 50 Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.EBI Uppsala University
8863806 68 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]EBI Université d'Orléans
8784448 63 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.EBI Uppsala University
8784447 63 10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.EBI Uppsala University
8759640 61 Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.EBI Warner-Lambert Company
8709129 18 Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.EBI Purdue University
8709107 99 Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.EBI Yamanouchi Pharmaceutical Company Limited
8691438 48 (S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.EBI Pharmacia & Upjohn
8676348 10 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone.EBI Polish Academy of Sciences
8667368 42 Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.EBI University of Camerino
8568802 42 Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.EBI Glaxo Wellcome Inc.
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8496920 14 (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.EBI Wyeth Research (UK)
8410989 58 Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents.EBI Solvay Duphar Research Laboratories
8355253 74 Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.EBI Virginia Commonwealth University
8340910 32 (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.EBI University of Göteborg
8289207 30 Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships.EBI Università di Bari
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8064802 9 Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.EBI Polish Academy of Sciences
8057297 24 5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.EBI Pfizer Inc
7996545 3 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.EBI Purdue University
7990123 30 Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors.EBI University of Pennsylvania
7932553 42 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists.EBI Göteborg University
7914539 36 Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.EBI Burroughs Wellcome Company
7914536 96 Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.EBI Hoechst-Roussel Pharmaceuticals, Inc.
7909336 27 A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.EBI R. W. Johnson Pharmaceutical Research Institute
7861420 62 C-9 and N-substituted analogs of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3- propyl-1H-benz[e]indole-9-carboxamide: 5-HT1A receptor agonists with various degrees of metabolic stability.EBI Upjohn Laboratories
7861413 11 (R)-11-hydroxy- and (R)-11-hydroxy-10-methylaporphine: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.EBI Uppsala University
7783152 170 Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.EBI Göteborg University
7783126 29 N4-unsubstituted N1-arylpiperazines as high-affinity 5-HT1A receptor ligands.EBI Solvay Duphar Research Laboratories
7752194 5 Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.EBI Pharmaceutical Research Institute
7731013 32 New (2-methoxyphenyl)piperazine derivatives as 5-HT1A receptor ligands with reduced alpha 1-adrenergic activity. Synthesis and structure-affinity relationships.EBI FAES, S.A.
7699712 20 Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.EBI Purdue University
7699710 84 High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.EBI Università di Bari
7658428 94 Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.EBI SmithKline Beecham Pharmaceuticals
7530773 31 Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.EBI Uppsala University
7506312 36 Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.EBI Uppsala University
3172131 23 Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands.EBI Virginia Commonwealth University
2965244 32 N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.EBI Virginia Commonwealth University
2902227 10 Serotonergic properties of spiroxatrine enantiomers.EBI University of Arizona
2795604 3 (R)- and (S)-5,6,7,8-tetrahydro-1-hydroxy-N,N-dipropyl-9H-benzocyclohepten- 8-ylamine. Stereoselective interactions with 5-HT1A receptors in the brain.EBI University of Uppsala
2754715 24 N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites?EBI Virginia Commonwealth University
2565400 132 Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.EBI McNeil Pharmaceutical and Janssen Research Foundation Worldwide
2537429 61 2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.EBI CIBA-GEIGY Corporation
2522991 8 Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.EBI University of Uppsala
2521252 15 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites.EBI Virginia Commonwealth University
2374139 50 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.EBI Pfizer Inc.
2299641 24 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin.EBI Virginia Commonwealth University
2213830 30 Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region.EBI Virginia Commonwealth University
2140413 6 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.EBI TBA
2137880 7 Novel [(diazomethyl)carbonyl]-1,2,3,4-tetrahydronaphthalene derivatives as potential photoaffinity ligands for the 5-HT1A receptor.EBI Mount Sinai School of Medicine
1977911 1 Potent anticonflict activity and lessening of memory impairment with a series of novel [1]benzothieno[2,3-c]pyridines and 1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines.EBI Asahi Chemical Industry Company, Ltd.
1732537 3 Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane.EBI Purdue University
1683407 32 Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
1676427 21 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.EBI Pfizer, Inc.
1652026 43 Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.EBI Virginia Commonwealth University
1652023 179 Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.EBI Abbott Laboratories
1648138 33 Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.EBI Universitá di Catania
1535661 24 Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.EBI Polish Academy of Sciences
1534585 8 Benzofuran bioisosteres of hallucinogenic tryptamines.EBI Purdue University
1433207 22 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists.EBI University of Göteborg
1433172 30 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.EBI Pfizer, Inc.
1353116 10 3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.EBI Hoechst-Roussel Pharmaceuticals, Inc.
19874209 11 New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.BDB University of Orléans
 6 Synthesis and pharmacological evaluation of 4-[2- hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4- azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dioneBDB The Medical University of Warsaw
11714892 4 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract.BDB Recordati S.p.A.
11714872 14 The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.BDB AstraZeneca R&D
10869410 62 S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.BDB Centre de Recherches de Croissy
10611634 78 Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.BDB Institut de Recherches Servier, Centre de Recherches de Croissy
10379421 134 Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.BDB TBA
9430133 176 Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence.BDB H. Lundbeck A/S
9400006 184 Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.BDB Emory University
9336327 37 The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299.BDB Preclinical R & D, Astra Arcus AB
9225287 174 RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist.BDB Roche Bioscience
9103528 17 PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.BDB Pharmacia & Upjohn, Inc.
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Janssen Research Foundation
8822531 111 Radioreceptor binding profile of the atypical antipsychotic olanzapine.BDB Lilly Research Laboratories
8788493 64 Novel discriminatory ligands for 5-HT2B receptors.BDB SmithKline Beecham Pharmaceuticals
8584042 40 BIMT 17, a 5-HT2A receptor antagonist and 5-HT1A receptor full agonist in rat cerebral cortex.BDB Boehringer Ingelheim Italia
8564266 77 Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed.BDB Vrije Universiteit
8564196 35 Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.BDB Syntex Discovery Research
8398139 29 A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms.BDB The Scripps Research Institute
8301575 55 Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.BDB Institut de Recherches Servier
7910212 34 Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.BDB Yamanouchi Pharmaceutical Co. Ltd.
6225026 45 Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.BDB INSERM U. 114
2869639 166 Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.BDB Astra Läkemedel AB
2583244 35 Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study.BDB Virginia Commonwealth University
2530094 94 The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.BDB Novo Industri A/S
1982626 30 Neurochemical profile of eltoprazine.BDB Duphar B.V.
1930610 41 Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors.BDB Eli Lilly and Company
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
17825569 48 The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.BDB Polish Academy of Science
19237285 44 Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.BDB CNRS