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539 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28319392 216 Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
28244748 119 The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.EBI Virginia Commonwealth University
28274674 93 Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors.EBI Chonnam National University
27997171 48 Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.EBI The University of Newcastle
27876250 60 Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI Jagiellonian University Medical College
27939174 84 Challenges in the development of an MEBI Vanderbilt University Medical Center
27839919 192 Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.EBI University of Kansas
27933960 122 Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.EBI National Institute on Drug Abuse
27933810 166 Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HTEBI National Institute of Diabetes and Digestive and Kidney Diseases
27280968 6 Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
27490956 59 Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.EBI Merck KGaA
27325446 42 Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.EBI Takeda Pharmaceutical Company Ltd
27080180 39 Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.EBI University of Arkansas for Medical Sciences
26988801 55 Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI Jagiellonian University Medical College
26935940 23 Emerging targets and new small molecule therapies in Parkinson's disease treatment.EBI School of Medicine of University of Electronic Science and Technology of China
26709102 142 Discovery of Vibegron: A Potent and Selective▀3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.EBI Merck Research Laboratories
26739781 237 Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.EBI The Alexander Shulgin Research Institute
26475518 19 Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.EBI City University of New York
26233799 15 Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.EBI Virginia Commonwealth University
25164761 41 Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors.EBI Shanghai Institute of Pharmaceutical Industry
26051602 51 Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.EBI Takeda Pharmaceutical Company Ltd
25879485 60 Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.EBI Seragon Pharmaceuticals
25695425 62 Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.EBI City University of New York
25827402 54 3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.EBI Teva Global R&D.
25593099 57 Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template.EBI Wayne State University
25070422 126 Further evaluation of the tropane analogs of haloperidol.EBI Florida A&M University
25050161 112 Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.EBI AMRI
25037917 56 Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.EBI Lexicon Pharmaceuticals
25017029 39 Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.EBI Takeda Pharmaceutical Company, Ltd
24974340 90 Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.EBI Korea University
24967667 45 Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.EBI AstraZeneca
24901260 12 Recent developments in novel antidepressants targetinga4▀2-nicotinic acetylcholine receptors.EBI University of Illinois at Chicago
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
24786728 1 Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.EBI University of Utah
25221656 116 Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-a-Oxyazetidine.EBI Korea University
25193229 102 Alpha-ethyltryptamines as dual dopamine-serotonin releasers.EBI Research Triangle Institute
24944732 37 Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.EBI RTI International
24944746 13 Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.EBI National Institute on Drug Abuse-Intramural Research Program
1271416 10 Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes.EBI TBA
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
24332089 35 Imidazole-derived agonists for the neurotensin 1 receptor.EBI Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute
23477943 51 Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.EBI Bristol-Myers Squibb Company
23168018 10 A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.EBI National Institute on Drug Abuse-Intramural Research Program
24900687 3 Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.EBI Janssen Research and Development, LLC
24900562 126 Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.EBI AstraZeneca
23061607 10 Organosilicon molecules with medicinal applications.EBI University of California-Davis
19592243 66 Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.EBI Roche Palo Alto LLC
15808487 137 The role of QSAR in dopamine interactions.EBI Pomona College
12657274 109 Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.EBI Abbott Laboratories
23084899 102 4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.EBI AMRI
22992024 21 Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.EBI Janssen-Cilag S.A.
22959245 175 As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI The University of Sydney
22082561 9 Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.EBI Johannes Gutenberg University
21486038 177 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.EBI H. Lundbeck A/S
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
23641311 38 From a4▀2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.EBI TBA
23025719 32 Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.EBI Pfizer Inc.
23006002 35 Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.EBI Suven Life Sciences Ltd.
22938049 29 Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.EBI Korea Institute of Science and Technology
23022052 6 A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.EBI Universit£ degli Studi di Milano
22832315 85 Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.EBI AstraZeneca
23066448 8 Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (▒)-threo-Methylphenidate.EBI TBA
22658558 10 Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter.EBI Beijing Normal University
22608762 25 Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.EBI Shanghai Institute of Pharmaceutical Industry
22749190 23 Wake-promoting agents: search for next generation modafinil: part IV.EBI Cephalon (France)
22520153 135 Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.EBI Florida A&M University
22607684 50 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.EBI The University of Sydney
22546675 24 Wake promoting agents: search for next generation modafinil, lessons learned: part III.EBI Cephalon, Inc.
22313242 146 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.EBI Pfizer Inc.
22313227 78 Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI National Institute of Mental Health
22398259 87 Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.EBI TUBITAK MAM Chemistry Institute P K 21 Gebze
21726069 98 Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.EBI University of Namur
21634396 55 Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.EBI Cephalon, Inc.
21058665 52 Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes.EBI Research Triangle Institute
21344069 43 Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues.EBI National Institute on Drug Abuse - Intramural Research Program
21207959 69 Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI National Institute of Mental Health
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
20931963 112 Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI ASKA Pharmaceutical Co, Ltd
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20724153 31 Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.EBI Korea Institute of Science and Technology
20597489 17 Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.EBI Emory University
20471260 146 Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.EBI Pfizer Global Research and Development
20153188 44 Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.EBI Pfizer Global Research and Development
20036131 68 Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.EBI University of Kentucky
19963380 38 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI Hunter College and the Graduate Center of the City University of New York
19740668 48 Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression.EBI Human BioMolecular Research Institute
19896846 44 Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes.EBI University of New Orleans
19821575 47 Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
19523837 54 Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters.EBI Research Triangle Institute
19821577 178 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.EBI Research Triangle Institute
19722525 31 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.EBI Wyeth Research
19329313 50 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.EBI Wyeth Research
17846138 26 Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.EBI Veterans Affairs Medical Center
19201198 210 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.EBI Human BioMolecular Research Institute
18954038 62 Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.EBI Neurocrine Biosciences, Inc.
18774292 72 Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.EBI National Institute on Drug Abuse-Intramural Research Program
18800760 96 Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.EBI Emory University
19067522 18 Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.EBI Emory University
19038547 62 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.EBI The State University of New York
19014888 52 Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.EBI Human BioMolecular Research Institute
18951020 34 Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.EBI Wyeth Research
18550369 82 Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).EBI Neurocrine Biosciences Inc.
18539031 126 Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.EBI Neurocrine Biosciences, Inc.
18672364 119 Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.EBI Neurocrine Biosciences, Inc.
18556210 75 Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.EBI Research Triangle Institute
17255098 2 Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.EBI University of North Dakota School of Medicine and Health Sciences
18468904 48 High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.EBI Purdue University
18434164 42 Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.EBI Research Triangle Institute
18417343 62 Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.EBI Pfizer Inc.
18313294 68 [4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.EBI Pfizer Inc.
18249549 54 Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.EBI Wayne State University
18278854 20 Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.EBI The University of Mississippi
18053732 26 The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.EBI Organix Inc.
18207394 126 Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.EBI Neurocrine Bioscience, Inc.
18468895 102 Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.EBI Neurocrine Bioscience, Inc.
18445525 141 Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.EBI Neurocrine Bioscience, Inc.
17983754 21 Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.EBI Emory University
18240382 104 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.EBI Pfizer Inc.
18060777 158 Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson& Johnson Pharmaceutical Research& Development L.L.C.
17228858 236 Advances in development of dopaminergic aporphinoids.EBI Chinese Academy of Sciences
17766113 51 Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17446076 187 Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.EBI University of Aarhus
17399987 11 3-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-6-substituted-3,6-diazabicyclo[3.1.1]heptanes as novel potent dopamine uptake inhibitors.EBI Universit£ di Sassari
17489581 95 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.EBI School of Chemistry and Biochemistry
17407815 27 Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.EBI Johnson& Johnson Pharmaceutical Research& Development
16279803 59 Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.EBI Research Triangle Institute
15566309 69 Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.EBI Research Triangle Institute
17228864 328 Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.EBI Massachusetts College of Pharmacy and Health Sciences
17034144 72 Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.EBI National Institute on Drug Abuse-Intramural Research Program
16750359 58 N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.EBI Pfizer Global Research and Development
16750363 101 Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.EBI Pfizer Global Research and Development
16821765 29 Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction.EBI Chinese Academy of Sciences
16854064 65 Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.EBI Research Triangle Institute
16480278 279 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.EBI Organix Inc.
16213721 60 N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.EBI National Institute on Drug Abuse--Intramural Research Program
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
16162005 30 Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
16165350 11 The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines.EBI Wake Forest University Health Sciences
15857139 31 Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.EBI Universit£ di Ferrara
15828826 17 Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.EBI Medical University of South Carolina
15743177 43 Synthesis and biological evaluation of meperidine analogues at monoamine transporters.EBI University of New Orleans
15916437 90 Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.EBI Research Triangle Institute
15537337 95 Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.EBI Acenta Discovery, Inc.
15456254 60 Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.EBI Wayne State University
15686927 39 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency.EBI Yale University
15546718 28 Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.EBI Organix Inc.
15163183 92 Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.EBI University of Illinois at Chicago
15027858 35 Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives.EBI University of New Orleans
14711303 115 Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.EBI Research Triangle Institute
15189035 67 Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.EBI National Institute on Drug Abuse--Intramural Research Program
12672245 54 Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.EBI School of Chemistry and Biochemistry
12646032 30 High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.EBI Wayne State University
14640559 405 Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.EBI FAES FARMA S A
12825932 61 Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.EBI National Institute on Drug Abuse
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI NIDA-IRP
12747792 12 Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.EBI Wayne State University
12723962 69 Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.EBI Georgetown University Medical Center
12723940 145 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.EBI Research Triangle Institute
11960503 140 Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.EBI Georgetown University Medical Center
11881989 7 Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters.EBI University of New Orleans
11806716 44 Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.EBI Wayne State University
12213053 117 Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
12190324 15 Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.EBI Research Triangle Institute
12109901 45 SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.EBI Georgetown University Medical Center
11300876 47 Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.EBI Wayne State University
11170654 72 Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.EBI National Institute on Drug Abuse-Intramural Research Program
11728190 10 Novel tropane-based irreversible ligands for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
11689080 43 Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI F-59000 Lille
11472216 89 Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.EBI Organix Inc.
11334571 79 Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.EBI Georgetown University Medical Center
10737754 30 Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
10737741 50 Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis.EBI National Institute on Drug Abuse-Intramural Research Program
11150168 165 Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse.EBI Pharm-Eco Laboratories
11123996 21 Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.EBI National Institute of Diabetes and Digestive and Kidney Diseases
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10649976 72 Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands.EBI Massachusetts General Hospital
10966747 7 Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects.EBI Georgetown University Medical Center
10956207 43 2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.EBI Organix Inc.
10821718 69 Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.EBI Georgetown University Medical Center
10072685 82 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors.EBI School of Chemistry and Biochemistry
10579846 68 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.EBI School of Chemistry and Biochemistry
10543888 60 Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.EBI National Institute on Drug Abuse-Intramural Research Program
10479296 66 Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors.EBI Massachusetts General Hospital
10479283 74 CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.EBI National Institute on Drug Abuse - Intramural Research Program
9526561 22 (-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake.EBI University of Maryland
9836615 106 Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters.EBI Georgetown University Medical Center
9804688 51 Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.EBI University of Minnesota
9804682 12 TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.EBI Institut f£r Bioanorganische und Radiopharmazeutische Chemie
9748351 16 New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.EBI Universita' di Siena
9457247 39 Synthesis and ligand binding of tropane ring analogues of paroxetine.EBI Research Triangle Institute
9632375 8 Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane.EBI University of New Orleans
9632371 28 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies.EBI University of Oklahoma Health Sciences Center
9599245 23 Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton.EBI Georgetown University Medical Center
9135033 36 Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter.EBI INSERM
9111298 18 Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.EBI Research Triangle Institute
9083474 12 Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives.EBI University of New Orleans
9083473 33 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.EBI National Institutes of Health
9435910 23 Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives.EBI University of New Orleans
9435903 14 Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
9397165 27 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.EBI Research Triangle Institute
9276012 53 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.EBI Organix Inc.
9258354 10 Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter.EBI University of Oklahoma
8691489 12 Synthesis and ligand binding of eta(6)-(2beta-carbomethoxy-3beta-phenyltropane) transition metal complexes.EBI University of New Orleans
8632426 62 Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs.EBI School of Chemistry and Biochemistry
8941387 10 Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives.EBI University of New Orleans
8941383 146 Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
8863789 31 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.EBI Research Triangle Institute
8831768 65 Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.EBI Research Triangle Institute
8558525 60 N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.EBI Research Biochemicals International
8558504 43 2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.EBI Organix Inc
8709106 89 Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.EBI Research Triangle Institute
7562926 81 Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.EBI National Institutes of Health
7830281 237 Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.EBI Research Triangle Institute
7658431 18 Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.EBI Research Triangle Institute
7636872 24 Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position.EBI Mayo Foundation for Medical Education and Research
8176704 40 Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.EBI Wake Forest University
8164265 42 Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.EBI National Institute on Drug Abuse
7966147 14 Synthesis, cocaine receptor affinity, and dopamine uptake inhibition of several new 2 beta-substituted 3 beta-phenyltropanes.EBI University of New Orleans
7932572 7 Structure-activity relationship studies of N-sulfonyl analogs of cocaine: role of ionic interaction in cocaine binding.EBI Trophix Pharmaceuticals, Inc.
8071935 25 Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.EBI Research Triangle Institute
8057273 9 Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.EBI National Institutes of Health
8035432 5 Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter.EBI University of Maryland
8027983 16 The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.EBI Organix Inc.
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8182712 14 Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.EBI University of Tennessee Medical Center at Knoxville 37920.
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8464040 21 Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.EBI Organix Inc.
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8246225 20 Analysis of cocaine receptor site ligand binding by three-dimensional Voronoi site modeling approach.EBI University of Michigan
8411004 48 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.EBI Research Triangle Institute
1552510 178 Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.EBI Research Triangle Institute
1469704 5 Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue.EBI Mayo Foundation for Education and Research
1619622 51 Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.EBI Research Triangle Institute
1588560 19 Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.EBI Research Triangle Institute
1732521 12 N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor.EBI Research Triangle Institute
1732520 21 2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.EBI Research Triangle Institute
1895292 16 Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.EBI Research Triangle Institute
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1833546 47 Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.EBI Abbott Laboratories
2903929 143 Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.EBI H. Lundbeck A/S
3039136 328 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
2999402 207 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.EBI TBA
6747993 69 Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.EBI TBA
6492080 195 Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.EBI TBA
6134833 91 Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.EBI TBA
7452682 76 3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.EBI TBA
15115403 48 Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15149693 56 The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.EBI National Institute on Drug Abuse--Intramural Research Program
12699762 27 Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.EBI Wayne State University
12565962 41 Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.EBI University of Michigan
14592523 42 Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.EBI Organix Inc.
14505672 78 Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors.EBI Georgetown University Medical Center
12798324 36 Bivalent biogenic amine reuptake inhibitors.EBI Human BioMolecular Research Institute
11909701 35 Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
12161139 11 Synthesis and dopamine transporter binding affinities of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes.EBI University of New Orleans
12127543 26 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.EBI Southern Research Institute
12067559 34 Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.EBI University of Michigan
11354356 42 Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.EBI Georgetown University Medical Center
11277529 14 Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.EBI Universit£ di Ferrara
11720867 24 [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse - Intramural Research Program
11714614 11 Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)-3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies.EBI Inha University
11527726 15 Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.EBI Wayne State University
11514143 71 Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.EBI Georgetown University Medical Center
10698458 26 Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine.EBI Georgetown University Medical Center
11078197 65 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.EBI Research Triangle Institute
10937724 56 Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors.EBI Georgetown University Medical Center
10888328 17 An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes.EBI Georgetown University Medical Center
10612593 33 N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter.EBI Georgetown University Medical Center
10406650 18 Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity.EBI Georgetown University Medical Center
9871604 114 Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.EBI Hong Kong University of Science and Technology
9934496 27 Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.EBI Research Triangle Institute
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 8 Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogenEBI TBA
 26 SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potencyEBI TBA
22341942 18 Wake-promoting agents: search for next generation modafinil: part II.EBI Cephalon, Inc.
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22226656 75 Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.EBI Cephalon, Inc.
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22055716 45 Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters.EBI University of New Orleans
22037049 62 Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.EBI Research Triangle Institute
21777010 26 Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging.EBI Janssen-Cilag SA
21458259 29 Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter.EBI Key Laboratory of Radiopharmaceuticals (Beijing Normal University)
21916421 68 Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).EBI Pfizer Inc.
21907583 48 CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.EBI University of South Florida
21899931 27 Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.EBI The University of Mississippi
21446715 43 Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.EBI Wayne State University
21319801 54 Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.EBI Research Triangle Institute
21310612 99 Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc.
21310609 108 Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc.
21095126 60 Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc
21093273 154 Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.EBI Sepracor Inc.
21146989 46 Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.EBI The University of Sydney
21146984 58 The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.EBI Organix Inc
21129986 18 Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.EBI Duquesne University Mylan School of Pharmacy
21112782 80 The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.EBI MSD
21185183 111 Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.EBI Pfizer Inc.
20980153 83 Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.EBI University of New Orleans
20971650 26 Discovery and synthesis of novel luteolin derivatives as DAT agonists.EBI Zhengzhou University
20949929 63 Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.EBI Bristol Myers Squibb
20812727 157 Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.EBI National Institute of Mental Health
20846865 80 Quantitative structure-activity relationship studies of threo-methylphenidate analogs.EBI Institute of Technology
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20692833 41 N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.EBI CSIRO Molecular and Health Technologies
20672825 67 Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.EBI National Institute on Drug Abuse-Intramural Research Program
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
20509659 182 Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.EBI Barrow Neurological Institute
20466553 6 Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.EBI Trinity College
20462211 92 Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).EBI Pfizer Global Research& Development
20378347 27 Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.EBI Wyeth Research
20137933 218 Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.EBI Amgen Inc.
19717215 56 Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.EBI Trinity College
19647430 104 N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.EBI Pfizer Global Research and Development
20034793 31 Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.EBI Bristol-Myers Squibb
20031410 84 Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.EBI Pfizer Global Research and Development
20022503 15 Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056).EBI Institute of Pharmaceutical Industry
19926484 26 Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.EBI INSERM
20158204 136 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.EBI Research Triangle Institute
20131864 59 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.EBI Wyeth Research
19954972 14 Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.EBI University of Sydney
19646882 72 Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and the Informatics Institute of UMDNJ
19560930 69 An extended study of dimeric phenyl tropanes.EBI Aarhus University
19740658 73 Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.EBI Pfizer Global Research and Development
19640707 12 Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
19854053 152 Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.EBI Pfizer Global Research and Development
19791802 21 Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.EBI Oregon State University
19616432 176 Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.EBI Pfizer Global Research and Development
19577467 2 Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter.EBI Institutet
19525112 1 [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies.EBI Brookhaven National Laboratory
19560923 20 Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.EBI Bristol-Myers SquibbPharmaceutical Research Institute
19359175 132 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.EBI Pfizer Global Research and Development
19442525 10 A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.EBI Duquesne University Mylan School of Pharmacy
8676127 40 Effects of Various Isoquinoline Alkaloids on In Vitro 3H-Dopamine Uptake by Rat Striatal SynaptosomesEBI TBA
8496700 16 The Role of Receptor Binding in Drug DiscoveryEBI TBA
 18 N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinityEBI TBA
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19492813 56 Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
19445453 87 Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.EBI National Institute on Drug Abuse-Intramural Research Program
19329329 183 Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19284718 191 Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.EBI University of Illinois at Chicago
19282174 85 Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.EBI Pfizer Global Research and Development
19053782 18 Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.EBI Emory University
19053748 57 Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.EBI Research Triangle Institute
18954985 111 Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.EBI Roche Palo Alto LLC
18954981 108 Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.EBI Neurocrine Biosciences, Inc.
18793858 27 Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.EBI INSERM
18782666 34 Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.EBI Pfizer Global Research and Development
18762424 4 New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18667309 123 Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.EBI Neurocrine Biosciences, Inc.
18644726 36 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.EBI Institut für Interdisziplinäre Isotopenforschung
18625557 60 N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.EBI Pfizer Global Research and Development
18621528 133 Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.EBI Pfizer Global Research and Development
18595716 142 Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.EBI Florida A&M University
18571404 132 Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.EBI Pfizer Global Research and Development
18557608 108 Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.EBI Wyeth Research
18487050 36 Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.EBI Hadassah-Hebrew University Hospital
18461921 65 Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions.EBI University of Maryland
17925440 2 A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.EBI Harvard Medical School
18085744 12 Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.EBI Emory University
18052090 39 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents.EBI University of Pennsylvania
17869101 60 High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors.EBI University of Aarhus
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17705359 3 Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.EBI Emory University
17690258 2 LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.EBI New York University School of Medicine
17658253 23 New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.EBI Institut für Interdisziplinäre Isotopenforschung
17616397 107 Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development LLC
17583504 51 Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
17571866 49 Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI National Institute of Mental Health
17517511 4 QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter.EBI University of Aarhus
17446069 15 Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.EBI Emory University
17418570 141 CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17391962 27 Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17350257 54 Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters.EBI University of Oslo
17328523 36 Novel sigma receptor ligands: synthesis and biological profile.EBI University of Catania
17267217 76 N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.EBI Pfizer Global Research and Development
17154506 6 Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.EBI Emory University
17127069 96 DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.EBI University Heights
17127059 96 Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17095215 25 Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.EBI Institute for Degenerative Diseases
17064081 10 Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.EBI National Institute on Drug Abuse-Intramural Research Program
16931001 93 2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
16908151 24 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.EBI Yale University
16905316 42 Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.EBI University of Kentucky
16821783 60 Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and noEBI Wayne State University
16784855 22 Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.EBI Emory University
16784853 5 High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots.EBI Vanderbilt University
16722655 28 Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.EBI Pfizer Global Research & Development
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16513343 3 (R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis.EBI Paradigm Therapeutics Ltd
16509591 75 Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.EBI NIDDK
16497500 128 N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.EBI Eli Lilly and Company
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16451060 3 Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.EBI Emory University
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
16361098 70 Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.EBI F. Hoffmann-La Roche Ltd
16337793 39 Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.EBI INSERM
16335921 99 Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.EBI University of Illinois at Chicago
16314097 113 Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.EBI Pfizer Global Research and Development
16302792 19 Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
16236497 48 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.EBI Yale University
16202585 30 Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes.EBI University of Illinois at Chicago
16137883 84 1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.EBI Eli Lilly and Company Ltd
16134937 154 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.EBI 7TM Pharma A/S
16033275 7 Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.EBI Wayne State University
15974579 36 Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.EBI Emory University
15863297 57 Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants.EBI Acenta Discovery, Inc.
15801845 45 Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.EBI Columbia University College of Physicians and Surgeons
15771448 187 Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.EBI Johnson & Johnson Pharmaceutical Research & Development
15566284 12 Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter.EBI National Institute on Drug Abuse
15482938 45 Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.EBI Harvard Medical School
15456270 24 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.EBI University of Pennsylvania
15177457 39 Synthesis and biological activity of some known and putative duloxetine metabolites.EBI Lilly Research Laboratories
15080991 38 Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).EBI Yale School of Medicine
15026075 51 Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
15012999 166 Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.EBI Merck Research Laboratories
14971892 32 Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.EBI Emory University
14643350 38 Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.EBI Lilly Research Laboratories
12951108 63 Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.EBI Lilly Research Centre
12877586 40 A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.EBI Organix Inc.
12672255 18 Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate.EBI Organix Inc.
12672246 68 Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.EBI NIDDK
12657288 102 Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.EBI NIDDK
12639545 37 Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes.EBI University of New Orleans
12620070 24 Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.EBI Emory University
12565970 44 Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
12361398 19 New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).EBI University of Pennsylvania
12213078 31 Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.EBI NIDDK
12213055 71 Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program/NIH
12213054 38 Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
11965364 36 Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
11958976 30 Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.EBI State University of New York
11882001 34 Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11881994 42 Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.EBI INSERM
11714608 30 Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.EBI Alcohol and Drug Abuse Research Center
11425531 2 [3H]MFZ 2-12: a novel radioligand for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
11356113 18 Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines.EBI Universidad de Valencia
11334561 63 Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
11229754 28 Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.EBI State University of New York
11133081 33 A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.EBI Georgetown University Medical Center
10969967 34 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.EBI Yale University
10956218 12 Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines.EBI Centre for Addiction and Mental Health
10937721 9 Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity.EBI University of Tokyo
10691690 6 Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.EBI Emory University
10669562 29 Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.EBI Georgetown University Medical Center
10612583 27 Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine.EBI University of New Orleans
10585212 138 Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10576690 13 Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine.EBI Georgetown University Medical Center
10425082 1 Pharmacotherapies for treatment of cocaine abuse: preclinical aspects.EBI Research Triangle Institute
9986702 11 A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.EBI University of Pennsylvania
9871666 4 Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons.EBI Novartis Pharma Inc.
9703474 21 Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.EBI Organix Inc.
9513598 20 Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.EBI Organix Inc.
9484494 2 Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging agents.EBI University of Pennsylvania
9435902 60 Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.EBI National Institute on Drug Abuse
9406593 5 1-[1-2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vitro: synthesis, identification from rat liver microsome extracts, and affinity for the neuronal dopamine transporter.EBI INSERM
9397171 81 N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.EBI University of Minnesota
9057857 169 Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9016326 38 Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.EBI Organix Inc.
8960553 60 Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
8691453 42 Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.EBI State University of New York
8576918 38 Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.EBI Organix Inc.
8515428 2 Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.EBI Northeastern University
8515426 12 Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.EBI University of Toledo
7562944 16 In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.EBI University of Oklahoma
3735309 50 Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.EBI TBA
1613745 1 Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography.EBI Brookhaven National Laboratory
28135235 71 An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.BDB Novartis Institutes for BioMedical Research
19337725 43 Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.BDB Case Western Reserve University
18387300 90 Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.BDB Pfizer Global Research and Development
16675639 28 Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.BDB Wyeth Research
16352709 44 Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.BDB McGill University
16339913 6 Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter.BDB Univ. Tours
15999145 62 Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex.BDB Case Western Reserve University
15879005 27 Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.BDB Duquesne University
15121762 11 Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.BDB University of Kentucky
14744476 35 Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.BDB Emory University
14573386 17 Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats.BDB Lilly Research Laboratories
12954796 58 In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.BDB National Institute on Drug Abuse
12784105 53 Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.BDB Case Western Reserve University
12761331 97 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.BDB Case Western Reserve University
12721338 61 N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.BDB Pudue Pharma Discovery Research
12649362 8 Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.BDB Georgetown University
12649361 779 L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.BDB Case Western Reserve University
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
12232544 79 [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine].BDB Emory University
12023542 23 Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats.BDB Harvard University
11961053 26 Biochemical and behavioral characterization of novel methylphenidate analogs.BDB Mercer University
11750183 29 Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders.BDB Novartis Pharma
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
11454918 90 S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.BDB Institut de Recherches Servier
11438309 51 The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.BDB Janssen Research Foundation
11082453 77 ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.BDB Abbott Laboratories
11071707 71 Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.BDB NIH
10773045 45 Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain.BDB Wake Forest University
10755640 2 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.BDB Emory University
10611634 78 Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.BDB Institut de Recherches Servier, Centre de Recherches de Croissy
10379421 134 Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.BDB TBA
10336510 53 Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.BDB Virginia Commonwealth University
9537821 119 Pharmacological profile of antidepressants and related compounds at human monoamine transporters.BDB Mayo Clinic Jacksonville
9223589 17 N-(3-lodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichloro phenyl)nortropane (beta-CDIT), a tropane derivative: pharmacological characterization as a specific ligand for the dopamine transporter in the rodent brain.BDB INSERM U316
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Janssen Research Foundation
8887981 72 A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.BDB Abbott Laboratories
8424846 7 LY248686, a new inhibitor of serotonin and norepinephrine uptake.BDB Eli Lilly and Company
8302271 63 Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.BDB University of Toronto
7518514 46 (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.BDB Abbott Laboratories
6310078 55 Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.BDB Pfizer Inc.,
6123593 24 A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.BDB Eli Lilly and Company
3790168 23 Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.BDB Wyeth Laboratories, Inc.
3419539 56 Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers.BDB Organon International
2905001 64 McN-5652: a highly potent inhibitor of serotonin uptake.BDB McNeil Pharmaceutical
2580950 69 Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.BDB Lundbeck AIS
2531826 24 [125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor.BDB NIDA Addiction Research Center
2530094 94 The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.BDB Novo Industri A/S
19256502 38 Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.BDB Human BioMolecular Research Institute
17602602 117 Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.BDB Research Triangle Institute
18393401 70 Design and Synthesis of 2- and 3-Substituted-3-phenylpropyl Analogs of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of Amino, Fluoro, Hydroxyl, Methoxyl, Methyl, Methylene, and Oxo Substituents on Affinity fBDB National Taiwan University