BindingDB logo
myBDB logout

593 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28319392 216 Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
28244748 119 The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.EBI Virginia Commonwealth University
28274674 93 Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors.EBI Chonnam National University
28089699 63 Investigation of piperazine benzamides as human▀EBI Merck& Co. Inc.
28041833 52 X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.EBI 3D-2drug, LLC
27876250 60 Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI Jagiellonian University Medical College
27939174 84 Challenges in the development of an MEBI Vanderbilt University Medical Center
27865645 62 Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HTEBI Sumitomo Dainippon Pharma Co., Ltd.
27537923 31 Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.EBI Universit£ Libre de Bruxelles
27839919 192 Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.EBI University of Kansas
27933960 122 Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.EBI National Institute on Drug Abuse
27280968 6 Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
27364609 230 Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.EBI Florida A&M University
27325446 42 Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.EBI Takeda Pharmaceutical Company Ltd
27312422 219 Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.EBI Florida A&M University
27160055 76 Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter.EBI Aarhus University
27080180 39 Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.EBI University of Arkansas for Medical Sciences
27041397 24 Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities.EBI Chonnam National University
26988801 55 Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI Jagiellonian University Medical College
26935940 23 Emerging targets and new small molecule therapies in Parkinson's disease treatment.EBI School of Medicine of University of Electronic Science and Technology of China
26704965 229 Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.EBI University of Illinois at Chicago
26709102 142 Discovery of Vibegron: A Potent and Selective▀3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.EBI Merck Research Laboratories
26748694 44 The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.EBI Gedeon Richter Plc
26739781 237 Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.EBI The Alexander Shulgin Research Institute
26372073 1 Reengineered tricyclic anti-cancer agents.EBI Icahn School of Medicine at Mt. Sinai
26337019 22 Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors.EBI Chonnam National University
26233799 15 Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.EBI Virginia Commonwealth University
25164761 41 Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors.EBI Shanghai Institute of Pharmaceutical Industry
26051602 51 Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.EBI Takeda Pharmaceutical Company Ltd
26153715 4 Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.EBI National Institute on Drug Abuse
25695425 62 Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.EBI City University of New York
25557493 109 Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.EBI Jagiellonian University Collegium Medicum
25593099 57 Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template.EBI Wayne State University
25461308 64 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4.EBI Medical University of Warsaw
25070422 126 Further evaluation of the tropane analogs of haloperidol.EBI Florida A&M University
25050161 112 Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.EBI AMRI
25017029 39 Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.EBI Takeda Pharmaceutical Company, Ltd
24974340 90 Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.EBI Korea University
24881566 140 Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI GlaxoSmithKline
25221656 116 Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-a-Oxyazetidine.EBI Korea University
25193229 102 Alpha-ethyltryptamines as dual dopamine-serotonin releasers.EBI Research Triangle Institute
24944732 37 Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.EBI RTI International
24944746 13 Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.EBI National Institute on Drug Abuse-Intramural Research Program
24805037 380 Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.EBI Adamed Ltd.
24942641 7 Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.EBI University of Barcelona
24717153 46 Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.EBI Gedeon Richter Plc
24900826 22 Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.EBI Therachem Research Medilab (India) Pvt. Ltd.
722762 2 Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms.EBI TBA
24559051 141 Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.EBI Intra-Cellular Therapies, Inc.
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
23581551 75 Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.EBI Universit£ Libre de Bruxelles
23477943 51 Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.EBI Bristol-Myers Squibb Company
23394318 1 Antidepressant abietane diterpenoids from Chinese eaglewood.EBI Chinese Academy of Medical Sciences and Peking Union Medical College
23385211 6 Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.EBI Trinity College
23253443 135 Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.EBI Bristol-Myers Squibb Research and Development
23168018 10 A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.EBI National Institute on Drug Abuse-Intramural Research Program
24900562 126 Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.EBI AstraZeneca
23279866 69 Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.EBI Jagiellonian University Medical College
23265880 8 A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol.EBI University of Pennsylvania
23061607 10 Organosilicon molecules with medicinal applications.EBI University of California-Davis
12372532 45 Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.EBI UCB Pharma SA
20951584 105 5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.EBI GlaxoSmithKline
19592243 66 Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.EBI Roche Palo Alto LLC
19286377 101 8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.EBI GlaxoSmithKline
18799312 84 6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.EBI GlaxoSmithKline
18829312 64 Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.EBI GlaxoSmithKline
18433113 124 Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.EBI GlaxoSmithKline
15745809 15 Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs).EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15261283 4 Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential.EBI Institute for Biological Research
12657274 109 Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.EBI Abbott Laboratories
11755367 38 First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.EBI UCB Pharma SA
23084899 102 4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.EBI AMRI
23043306 69 Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.EBI NeuroSearch Sweden AB
22959245 175 As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI The University of Sydney
22082561 9 Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.EBI Johannes Gutenberg University
21486038 177 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.EBI H. Lundbeck A/S
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
23006002 35 Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.EBI Suven Life Sciences Ltd.
22224640 53 Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.EBI Oxagen Ltd.
22938049 29 Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.EBI Korea Institute of Science and Technology
23022052 6 A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.EBI Universit£ degli Studi di Milano
22608762 25 Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.EBI Shanghai Institute of Pharmaceutical Industry
22749190 23 Wake-promoting agents: search for next generation modafinil: part IV.EBI Cephalon (France)
22520153 135 Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.EBI Florida A&M University
22607684 50 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.EBI The University of Sydney
22542010 31 Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.EBI Amgen San Francisco
22313242 146 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.EBI Pfizer Inc.
22313227 78 Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI National Institute of Mental Health
22398259 87 Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.EBI TUBITAK MAM Chemistry Institute P K 21 Gebze
21927645 1 NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor.EBI TBA
21859078 62 Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with highs1 receptor affinity.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
21726069 98 Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.EBI University of Namur
21058665 52 Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes.EBI Research Triangle Institute
21344069 43 Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues.EBI National Institute on Drug Abuse - Intramural Research Program
21207959 69 Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI National Institute of Mental Health
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20724153 31 Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.EBI Korea Institute of Science and Technology
20597489 17 Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.EBI Emory University
20471260 146 Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.EBI Pfizer Global Research and Development
20153188 44 Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.EBI Pfizer Global Research and Development
20036131 68 Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.EBI University of Kentucky
19963380 38 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI Hunter College and the Graduate Center of the City University of New York
19740668 48 Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression.EBI Human BioMolecular Research Institute
19896846 44 Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes.EBI University of New Orleans
19720528 54 Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.EBI Wyeth Research
19821575 47 Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
19523837 54 Synthesis and structure-activity relationship of 3beta-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3beta-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters.EBI Research Triangle Institute
19821577 178 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.EBI Research Triangle Institute
19722525 31 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.EBI Wyeth Research
19329313 50 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.EBI Wyeth Research
17846138 26 Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.EBI Veterans Affairs Medical Center
19201198 210 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.EBI Human BioMolecular Research Institute
18954038 62 Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.EBI Neurocrine Biosciences, Inc.
18774292 72 Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.EBI National Institute on Drug Abuse-Intramural Research Program
19159187 38 Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.EBI Universitat de Barcelona
18800760 96 Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.EBI Emory University
19067522 18 Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.EBI Emory University
19038547 62 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.EBI The State University of New York
19014888 52 Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression.EBI Human BioMolecular Research Institute
18951020 34 Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.EBI Wyeth Research
18847250 37 Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.EBI Virginia Commonwealth University
18834188 232 Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.EBI Wyeth Research
18771916 37 Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.EBI Wyeth Research
18760923 37 Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists.EBI Universit£ degli Studi di Perugia
18550369 82 Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).EBI Neurocrine Biosciences Inc.
18539031 126 Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.EBI Neurocrine Biosciences, Inc.
18672364 119 Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.EBI Neurocrine Biosciences, Inc.
18556210 75 Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.EBI Research Triangle Institute
18468904 48 High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.EBI Purdue University
18434164 42 Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.EBI Research Triangle Institute
18417343 62 Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.EBI Pfizer Inc.
18313294 68 [4-(Phenoxy)pyridin-3-yl]methylamines: a new class of selective noradrenaline reuptake inhibitors.EBI Pfizer Inc.
18249549 54 Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.EBI Wayne State University
18221879 13 Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.EBI Westf£lische Wilhelms-Universit£t M£nster
18278854 20 Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.EBI The University of Mississippi
18053732 26 The synthesis of bivalent 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters.EBI Organix Inc.
18207394 126 Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.EBI Neurocrine Bioscience, Inc.
18468895 102 Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.EBI Neurocrine Bioscience, Inc.
18445525 141 Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.EBI Neurocrine Bioscience, Inc.
17983754 21 Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.EBI Emory University
18242987 75 In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.EBI Sepracor Inc.
18240382 104 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.EBI Pfizer Inc.
18060777 158 Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson& Johnson Pharmaceutical Research& Development L.L.C.
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
17228858 236 Advances in development of dopaminergic aporphinoids.EBI Chinese Academy of Sciences
17766113 51 Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17446076 187 Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.EBI University of Aarhus
17489581 95 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.EBI School of Chemistry and Biochemistry
17407815 27 Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.EBI Johnson& Johnson Pharmaceutical Research& Development
17267226 46 Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity.EBI Taisho Pharmaceutical Co., Ltd
16279803 59 Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.EBI Research Triangle Institute
15566309 69 Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.EBI Research Triangle Institute
17228864 328 Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.EBI Massachusetts College of Pharmacy and Health Sciences
17034144 72 Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.EBI National Institute on Drug Abuse-Intramural Research Program
16750359 58 N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.EBI Pfizer Global Research and Development
16750363 101 Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.EBI Pfizer Global Research and Development
16854086 96 Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
16821765 29 Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction.EBI Chinese Academy of Sciences
16854064 65 Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.EBI Research Triangle Institute
16480278 279 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.EBI Organix Inc.
16257206 18 Derivatives of tramadol for increased duration of effect.EBI Sepracor Inc.
16213721 60 N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.EBI National Institute on Drug Abuse--Intramural Research Program
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
16162005 30 Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15857139 31 Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.EBI Universit£ di Ferrara
15828826 17 Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.EBI Medical University of South Carolina
15801844 25 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI Universidad Complutense
15743177 43 Synthesis and biological evaluation of meperidine analogues at monoamine transporters.EBI University of New Orleans
15916437 90 Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.EBI Research Triangle Institute
15537337 95 Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.EBI Acenta Discovery, Inc.
15456254 60 Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.EBI Wayne State University
15686927 39 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency.EBI Yale University
15546718 28 Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.EBI Organix Inc.
15163183 92 Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring.EBI University of Illinois at Chicago
15027858 35 Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives.EBI University of New Orleans
14711303 115 Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.EBI Research Triangle Institute
15189035 67 Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.EBI National Institute on Drug Abuse--Intramural Research Program
12672245 54 Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.EBI School of Chemistry and Biochemistry
12646032 30 High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.EBI Wayne State University
14640559 405 Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.EBI FAES FARMA S A
12954071 109 A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.EBI Alcon Research, Ltd.
12825932 61 Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporter.EBI National Institute on Drug Abuse
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI NIDA-IRP
12747792 12 Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.EBI Wayne State University
12723962 69 Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.EBI Georgetown University Medical Center
12723940 145 2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.EBI Research Triangle Institute
11960503 140 Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.EBI Georgetown University Medical Center
11806716 44 Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.EBI Wayne State University
12213053 117 Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
12190324 15 Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.EBI Research Triangle Institute
12109901 45 SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.EBI Georgetown University Medical Center
11300876 47 Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.EBI Wayne State University
11170654 72 Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.EBI National Institute on Drug Abuse-Intramural Research Program
11689080 43 Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11472216 89 Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.EBI Organix Inc.
11334571 79 Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.EBI Georgetown University Medical Center
10737754 30 Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
11150168 165 Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse.EBI Pharm-Eco Laboratories
11123996 21 Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11123994 72 Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
10649976 72 Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands.EBI Massachusetts General Hospital
10956207 43 2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.EBI Organix Inc.
10821718 69 Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.EBI Georgetown University Medical Center
10229626 66 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.EBI Universit£ di Siena
10579846 68 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.EBI School of Chemistry and Biochemistry
10543888 60 Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.EBI National Institute on Drug Abuse-Intramural Research Program
10479296 66 Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors.EBI Massachusetts General Hospital
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI Universit£ di Siena
9836615 106 Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters.EBI Georgetown University Medical Center
9804688 51 Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.EBI University of Minnesota
9804682 12 TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter.EBI Institut f£r Bioanorganische und Radiopharmazeutische Chemie
9457247 39 Synthesis and ligand binding of tropane ring analogues of paroxetine.EBI Research Triangle Institute
9632371 28 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies.EBI University of Oklahoma Health Sciences Center
9135033 36 Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compounds for the dopamine transporter.EBI INSERM
9111298 18 Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.EBI Research Triangle Institute
9397165 27 3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.EBI Research Triangle Institute
9276012 53 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.EBI Organix Inc.
8941383 146 Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).EBI National Institute of Diabetes and Digestive and Kidney Diseases
8863789 31 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.EBI Research Triangle Institute
8831768 65 Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.EBI Research Triangle Institute
8558525 60 N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.EBI Research Biochemicals International
8558504 43 2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.EBI Organix Inc
8709106 89 Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.EBI Research Triangle Institute
7830281 237 Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.EBI Research Triangle Institute
7658431 18 Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.EBI Research Triangle Institute
7629808 64 Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.EBI Universit£ di Siena
8176704 40 Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.EBI Wake Forest University
8164265 42 Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.EBI National Institute on Drug Abuse
8027983 16 The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.EBI Organix Inc.
8464040 21 Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.EBI Organix Inc.
8411004 48 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.EBI Research Triangle Institute
1619622 51 Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.EBI Research Triangle Institute
1920365 8 [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.EBI Research Biochemicals Inc.
1976813 83 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.EBI Wyeth-Ayerst Research
2903929 143 Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.EBI H. Lundbeck A/S
3039136 328 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
4032430 4 Molecular mechanism of action of 5,6-dihydroxytryptamine. Synthesis and biological evaluation of 4-methyl-, 7-methyl-, and 4,7-dimethyl-5,6-dihydroxytryptamines.EBI TBA
2999402 207 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.EBI TBA
6747993 69 Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.EBI TBA
6492080 195 Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.EBI TBA
6134833 91 Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.EBI TBA
7452682 76 3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.EBI TBA
15115403 48 Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15149693 56 The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.EBI National Institute on Drug Abuse--Intramural Research Program
15109634 129 SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis.EBI Eli Lilly and Co. Ltd
12699762 27 Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter.EBI Wayne State University
12565962 41 Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.EBI University of Michigan
14592523 42 Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.EBI Organix Inc.
14505672 78 Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors.EBI Georgetown University Medical Center
12798324 36 Bivalent biogenic amine reuptake inhibitors.EBI Human BioMolecular Research Institute
11909701 35 Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.EBI Georgetown University Medical Center
11859009 16 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.EBI Inha University
12127543 26 Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.EBI Southern Research Institute
12067559 34 Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.EBI University of Michigan
11354356 42 Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.EBI Georgetown University Medical Center
11277529 14 Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.EBI Universit£ di Ferrara
11720867 24 [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse - Intramural Research Program
11527726 15 Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.EBI Wayne State University
11514143 71 Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.EBI Georgetown University Medical Center
10698458 26 Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine.EBI Georgetown University Medical Center
11078197 65 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.EBI Research Triangle Institute
10937724 56 Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors.EBI Georgetown University Medical Center
10915050 14 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1.EBI Inha University
10888328 17 An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes.EBI Georgetown University Medical Center
10206550 28 Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.EBI Organix Inc
10612593 33 N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter.EBI Georgetown University Medical Center
10576696 32 Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.EBI Merck
9871604 114 Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.EBI Hong Kong University of Science and Technology
9934496 27 Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.EBI Research Triangle Institute
 28 Synthesis and evaluation of novel-N-[2-(bis-aryl-methoxy)ethyl-N-aralkyl-,-alkanediamines as potent and selective dopamine reuptake inhibitors: Seco analogs of GBR12935 and GBR12909EBI TBA
 8 Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining -2 antagonism with 5-HT uptake inhibitionEBI TBA
22341942 18 Wake-promoting agents: search for next generation modafinil: part II.EBI Cephalon, Inc.
22264475 10 Wake-promoting agents: search for next generation modafinil: part I.EBI Cephalon, Inc.
22309909 37 Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.EBI National Medicines Institute
22300887 8 QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).EBI INSERM
22123324 36 Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.EBI Amgen Inc.
22055716 45 Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters.EBI University of New Orleans
22037049 62 Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.EBI Research Triangle Institute
21458259 29 Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter.EBI Key Laboratory of Radiopharmaceuticals (Beijing Normal University)
21782428 61 Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.EBI Lundbeck Research USA, Inc.
21916421 68 Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).EBI Pfizer Inc.
21899931 27 Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.EBI The University of Mississippi
21823597 373 Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.EBI Green Cross Corporation
21469694 4 Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.EBI University of Navarra
21446715 43 Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.EBI Wayne State University
21319801 54 Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.EBI Research Triangle Institute
21398123 56 The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).EBI AstraZeneca Charnwood
21310612 99 Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc.
21310609 108 Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc.
21227702 9 Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.EBI Trinity College
21093118 32 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3.EBI Medical University of Warsaw
21095126 60 Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.EBI Sunovion Pharmaceuticals Inc
21093273 154 Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.EBI Sepracor Inc.
21146989 46 Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.EBI The University of Sydney
21146984 58 The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.EBI Organix Inc
21112782 80 The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.EBI MSD
21185183 111 Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.EBI Pfizer Inc.
20980153 83 Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.EBI University of New Orleans
20949929 63 Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.EBI Bristol Myers Squibb
20945906 33 Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.EBI Abbott Laboratories
20933409 50 Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.EBI Green Cross Corporation
20812727 157 Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.EBI National Institute of Mental Health
20801650 245 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics.EBI Pfizer Inc.
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20692833 41 N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.EBI CSIRO Molecular and Health Technologies
20672825 67 Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.EBI National Institute on Drug Abuse-Intramural Research Program
20637635 180 Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.EBI Green Cross Corporation
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
20509659 182 Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.EBI Barrow Neurological Institute
20466553 6 Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.EBI Trinity College
20529687 3 Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.EBI Columbia University
20462211 92 Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).EBI Pfizer Global Research& Development
20378347 27 Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.EBI Wyeth Research
20347298 28 Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.EBI Wyeth Research
20149649 133 Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.EBI Green Cross Corporation
20137933 218 Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.EBI Amgen Inc.
19717215 56 Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.EBI Trinity College
19647430 104 N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.EBI Pfizer Global Research and Development
20034793 31 Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.EBI Bristol-Myers Squibb
20031410 84 Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.EBI Pfizer Global Research and Development
20022503 15 Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056).EBI Institute of Pharmaceutical Industry
19926484 26 Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.EBI INSERM
20158204 136 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.EBI Research Triangle Institute
20131864 59 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.EBI Wyeth Research
20064720 44 Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
19932965 80 Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.EBI Wyeth Research
19646882 72 Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and the Informatics Institute of UMDNJ
19560930 69 An extended study of dimeric phenyl tropanes.EBI Aarhus University
19740658 73 Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.EBI Pfizer Global Research and Development
19665823 38 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.EBI Medical University of Warsaw
19640707 12 Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
19632110 29 Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.EBI Wyeth Research
19739674 39 Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.EBI Universitat de Barcelona
19713106 66 Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.EBI Wyeth Research
19854053 152 Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.EBI Pfizer Global Research and Development
19791802 21 Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.EBI Oregon State University
19616432 176 Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.EBI Pfizer Global Research and Development
19596193 72 Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.EBI Tsukuba Research Institute
19560923 20 Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.EBI Bristol-Myers SquibbPharmaceutical Research Institute
19719241 55 Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.EBI Wyeth Research
19359175 132 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.EBI Pfizer Global Research and Development
8496700 16 The Role of Receptor Binding in Drug DiscoveryEBI TBA
 49 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI TBA
 18 N-Phthalimidoalkyl derivatives of 2β-carbomethoxy-3β-(4′-iodophenyl)tropane (β-CIT): Brain monoamine transporter affinityEBI TBA
 34 Bivalent indoles exhibiting serotonergic binding affinityEBI TBA
19492813 56 Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.EBI GlaxoSmithKline
19445453 87 Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.EBI National Institute on Drug Abuse-Intramural Research Program
19329329 183 Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19284718 191 Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.EBI University of Illinois at Chicago
19282174 85 Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.EBI Pfizer Global Research and Development
19053782 18 Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.EBI Emory University
19053748 57 Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.EBI Research Triangle Institute
18995929 24 Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, part 1.EBI Medical University of Warsaw
18954985 111 Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.EBI Roche Palo Alto LLC
18954981 108 Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.EBI Neurocrine Biosciences, Inc.
18948001 179 Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities.EBI Pfizer Global Research and Development
18793858 27 Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging.EBI INSERM
18783208 11 Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.EBI National Institute of Mental Health
18782666 34 Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.EBI Pfizer Global Research and Development
18762424 4 New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.EBI University of Glasgow
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18667309 123 Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.EBI Neurocrine Biosciences, Inc.
18644726 36 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination.EBI Institut für Interdisziplinäre Isotopenforschung
18625557 60 N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.EBI Pfizer Global Research and Development
18621528 133 Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.EBI Pfizer Global Research and Development
18595716 142 Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.EBI Florida A&M University
18571421 78 Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.EBI Wyeth Research
18571404 132 Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.EBI Pfizer Global Research and Development
18557608 108 Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.EBI Wyeth Research
18487050 36 Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.EBI Hadassah-Hebrew University Hospital
18461921 65 Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions.EBI University of Maryland
17698848 4 Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.EBI Yale University
18085744 12 Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.EBI Emory University
18052090 39 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents.EBI University of Pennsylvania
17900912 15 1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.EBI Università di Milano
17869101 60 High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors.EBI University of Aarhus
17766114 2 Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): a high affinity SERT ligand for conjugation to quantum dots.EBI Vanderbilt University
17765543 56 Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17705359 3 Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.EBI Emory University
17690258 2 LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.EBI New York University School of Medicine
17658253 23 New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET.EBI Institut für Interdisziplinäre Isotopenforschung
17616397 107 Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development LLC
17583504 51 Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
17571866 49 Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI National Institute of Mental Health
17446069 15 Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.EBI Emory University
17434731 51 Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.EBI Lilly SA
17418570 141 CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17412583 81 Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.EBI Johnson & Johnson Pharmaceutical Research & Development
17407811 34 Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor.EBI Wyeth Research
17391962 27 Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17376695 7 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.EBI Inha University
17350257 54 Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters.EBI University of Oslo
17328523 36 Novel sigma receptor ligands: synthesis and biological profile.EBI University of Catania
17317177 69 Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17307358 81 Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.EBI Johnson & Johnson Pharmaceutical Research & Development L.L.C.
17267217 76 N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.EBI Pfizer Global Research and Development
17234422 118 Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor.EBI Taisho Pharmaceutical Co., Ltd
17154506 6 Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.EBI Emory University
17127069 96 DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.EBI University Heights
17127059 96 Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
17107798 90 Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
17095215 25 Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.EBI Institute for Degenerative Diseases
17064081 10 Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.EBI National Institute on Drug Abuse-Intramural Research Program
16931001 93 2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
16908151 24 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.EBI Yale University
16905316 42 Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.EBI University of Kentucky
16821783 60 Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and noEBI Wayne State University
16784855 22 Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.EBI Emory University
16753296 25 Discovery of potent CRTh2 (DP2) receptor antagonists.EBI AstraZeneca R&D Charnwood
16722655 28 Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.EBI Pfizer Global Research & Development
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16513343 3 (R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis.EBI Paradigm Therapeutics Ltd
16509591 75 Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.EBI NIDDK
16497500 128 N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.EBI Eli Lilly and Company
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16451060 3 Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.EBI Emory University
16392816 113 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.EBI Alcon Research, Ltd.
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
16361098 70 Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.EBI F. Hoffmann-La Roche Ltd
16337793 39 Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.EBI INSERM
16335921 99 Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.EBI University of Illinois at Chicago
16332439 58 Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.EBI Wyeth Research
16314097 113 Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.EBI Pfizer Global Research and Development
16302792 19 Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
16298130 32 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5.EBI Lilly Research Laboratories
16250644 66 Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition.EBI Solvay Pharma
16236497 48 Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.EBI Yale University
16202585 30 Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes.EBI University of Illinois at Chicago
16183285 4 Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots.EBI Vanderbilt University
16137883 84 1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.EBI Eli Lilly and Company Ltd
16033275 7 Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.EBI Wayne State University
16033253 27 Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.EBI Schering-Plough Research Institute
15974579 36 Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.EBI Emory University
15863297 57 Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants.EBI Acenta Discovery, Inc.
15801845 45 Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.EBI Columbia University College of Physicians and Surgeons
15771448 187 Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.EBI Johnson & Johnson Pharmaceutical Research & Development
15686885 28 Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.EBI Wyeth Research
15482938 45 Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents.EBI Harvard Medical School
15456270 24 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.EBI University of Pennsylvania
15454211 19 Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity.EBI Wyeth Research
15357973 24 Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15239661 120 Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.EBI Wyeth Research
15177457 39 Synthesis and biological activity of some known and putative duloxetine metabolites.EBI Lilly Research Laboratories
15125959 72 Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety.EBI Johnson & Johnson Pharmaceutical Research & Development
15109671 29 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4.EBI Lilly Research Laboratories
15081025 23 Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).EBI Virginia Commonwealth University
15080991 38 Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).EBI Yale School of Medicine
15026075 51 Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
14971892 32 Synthesis, radiosynthesis, and biological evaluation of carbon-11 and iodine-123 labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-haloethenyl)phenyl]tropanes: candidate radioligands for in vivo imaging of the serotonin transporter.EBI Emory University
14698193 43 Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane.EBI Wyeth Research
14643350 38 Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.EBI Lilly Research Laboratories
14643338 124 Binding of beta-carbolines at 5-HT(2) serotonin receptors.EBI Virginia Commonwealth University
14592479 60 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.EBI Lilly Research Laboratories
12951108 63 Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.EBI Lilly Research Centre
12877586 40 A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.EBI Organix Inc.
12873501 110 Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and alpha(2)-adrenoceptor antagonistic activities: a novel series of potential antidepressants.EBI Johnson & Johnson Pharmaceutical Research & Development
12824042 64 Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT(1A) receptor antagonism/SSRI activities. Part 2.EBI Lilly Research Laboratories
12749894 48 Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1.EBI Lilly Research Laboratories
12672246 68 Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.EBI NIDDK
12668005 21 Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.EBI Universidad Complutense
12657288 102 Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.EBI NIDDK
12639545 37 Synthesis of dopamine transporter selective 3-[2-(diarylmethoxyethylidene)]-8-alkylaryl-8-azabicyclo[3.2.1]octanes.EBI University of New Orleans
12620070 24 Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.EBI Emory University
12565970 44 Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
12565939 38 SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition.EBI Solvay Pharma
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12443787 2 Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.EBI Institutet
12372513 102 Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.EBI Neurogen Corporation
12361398 19 New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).EBI University of Pennsylvania
12213078 31 Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.EBI NIDDK
12213056 42 Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.EBI Universidad de Navarra
12213054 38 Benzo- and cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI University Center for Pharmacy
11965364 36 Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.EBI National Institute on Drug Abuse-Intramural Research Program
11958976 30 Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.EBI State University of New York
11882001 34 Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11881994 42 Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.EBI INSERM
11814784 53 Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.EBI Wyeth-Ayerst Research Laboratories
11714608 30 Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.EBI Alcohol and Drug Abuse Research Center
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI Universidad de Navarra
11459653 31 Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.EBI Wyeth-Ayerst Research Laboratories
11334561 63 Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.EBI State University of New York
11229754 28 Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.EBI State University of New York
11133081 33 A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.EBI Georgetown University Medical Center
11128642 5 Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine.EBI Central Washington University
10969967 34 Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.EBI Yale University
10956218 12 Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines.EBI Centre for Addiction and Mental Health
10782691 1 Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics.EBI Laboratoires UPSA
10715164 57 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.EBI Virginia Commonwealth University
10691690 6 Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.EBI Emory University
10669578 44 New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.EBI University of Groningen
10669562 29 Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.EBI Georgetown University Medical Center
10612583 27 Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine.EBI University of New Orleans
10585212 138 Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.EBI National Institute of Diabetes and Digestive and Kidney Diseases
10576690 13 Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine.EBI Georgetown University Medical Center
9986702 11 A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.EBI University of Pennsylvania
9871666 4 Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons.EBI Novartis Pharma Inc.
9719604 11 Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.EBI Hokkaido University
9703474 21 Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.EBI Organix Inc.
9526575 14 Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).EBI Purdue University
9513598 20 Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues.EBI Organix Inc.
9435902 60 Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.EBI National Institute on Drug Abuse
9397171 81 N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.EBI University of Minnesota
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
9191960 21 A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.EBI Organix Inc.
9089327 58 Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities.EBI Abbott Park
9057857 169 Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9016326 38 Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.EBI Organix Inc.
9016323 2 Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.EBI University of Pennsylvania
8960553 60 Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI Drew University
8941398 17 Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.EBI Hokkaido University
8691453 42 Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.EBI State University of New York
8576918 38 Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.EBI Organix Inc.
8515428 2 Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.EBI Northeastern University
8515426 12 Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.EBI University of Toledo
8487257 57 New indole derivatives as potent and selective serotonin uptake inhibitors.EBI Centre de Recherches de Vitry-Alfortville
6716399 2 Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.EBI TBA
6458703 72 Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.EBI TBA
3735309 50 Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2,3-dihydroindoles.EBI TBA
1967651 2 Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).EBI Purdue University
28135235 71 An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.BDB Novartis Institutes for BioMedical Research
23574807 12 Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.BDB University of Troms£
18387300 90 Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.BDB Pfizer Global Research and Development
16675639 28 Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.BDB Wyeth Research
15999145 62 Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex.BDB Case Western Reserve University
15356216 48 Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.BDB Farmaceutiche e Farmacologiche
15169827 3 Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.BDB University of Texas at Austin
15121762 11 Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.BDB University of Kentucky
14744476 35 Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.BDB Emory University
14573386 17 Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats.BDB Lilly Research Laboratories
12954796 58 In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.BDB National Institute on Drug Abuse
12761331 97 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.BDB Case Western Reserve University
12649362 8 Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.BDB Georgetown University
12649361 779 L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.BDB Case Western Reserve University
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
12232544 79 [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine].BDB Emory University
12110997 380 In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.BDB Westfälische Wilhelms-Universitä Muenster,
12023542 23 Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats.BDB Harvard University
11961053 26 Biochemical and behavioral characterization of novel methylphenidate analogs.BDB Mercer University
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
11714872 14 The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.BDB AstraZeneca R&D
11512051 80 The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor.BDB Case Western Reserve University
11454918 90 S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.BDB Institut de Recherches Servier
11071707 71 Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.BDB NIH
10611634 78 Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.BDB Institut de Recherches Servier, Centre de Recherches de Croissy
10379421 134 Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.BDB TBA
10340630 3 Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites.BDB McGill University
10336510 53 Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.BDB Virginia Commonwealth University
9669506 12 Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.BDB McGill University
9537821 119 Pharmacological profile of antidepressants and related compounds at human monoamine transporters.BDB Mayo Clinic Jacksonville
9400006 184 Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.BDB Emory University
9223589 17 N-(3-lodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(3',4'-dichloro phenyl)nortropane (beta-CDIT), a tropane derivative: pharmacological characterization as a specific ligand for the dopamine transporter in the rodent brain.BDB INSERM U316
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Janssen Research Foundation
8876023 52 Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.BDB University of Turku
8424846 7 LY248686, a new inhibitor of serotonin and norepinephrine uptake.BDB Eli Lilly and Company
8413837 45 [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.BDB Boots Pharmaceuticals
7562497 127 Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.BDB R.W. Johnson Pharmaceutical Research Institute
6310078 55 Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.BDB Pfizer Inc.,
6123593 24 A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.BDB Eli Lilly and Company
3790168 23 Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.BDB Wyeth Laboratories, Inc.
3419539 56 Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers.BDB Organon International
2970277 11 Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine.BDB Veterans Administration Medical Center
2905001 64 McN-5652: a highly potent inhibitor of serotonin uptake.BDB McNeil Pharmaceutical
2580950 69 Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin.BDB Lundbeck AIS
2530094 94 The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.BDB Novo Industri A/S
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
19256502 38 Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.BDB Human BioMolecular Research Institute
18812261 8 The molecular interactions of buspirone analogues with the serotonin transporter.BDB National Medicines Institute
17602602 117 Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.BDB Research Triangle Institute
18393401 70 Design and Synthesis of 2- and 3-Substituted-3-phenylpropyl Analogs of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of Amino, Fluoro, Hydroxyl, Methoxyl, Methyl, Methylene, and Oxo Substituents on Affinity fBDB National Taiwan University