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130 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28523109 79 Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.EBI GlaxoSmithKline
27964995 42 Synthesis and optimization of novela-phenylglycinamides as selective TRPM8 antagonists.EBI Kissei Pharmaceutical Co., Ltd.
27637151 35 Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.EBI Shionogi& Co., Ltd.
27317643 24 Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.EBI Seoul National University
26942860 101 Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.EBI Amgen, Inc.
26850005 89 Arylboronic acids as dual-action FAAH and TRPV1 ligands.EBI Sapienza Universit£ di Roma
26860926 46 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.EBI Seoul National University
26750258 67 TRPA1 channels as targets for resveratrol and related stilbenoids.EBI Sapienza Universit£ di Roma
26474664 76 Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.EBI Seoul National University
26235950 41 Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.EBI Renovis, Inc.
25666822 19 Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.EBI Universit£ del Piemonte Orientale
26263397 22 Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard.EBI University of Shizuoka
25937016 29 a-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.EBI Seoul National University
25850459 46 Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).EBI TBA
25935641 88 Structure-activity relationships of the prototypical TRPM8 agonist icilin.EBI National Research Council
25659771 36 Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.EBI Seoul National University
25597011 16 6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.EBI Shenyang Pharmaceutical University
25100568 68 Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.EBI AbbVie Inc.
25065940 77 Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.EBI Universit£ degli Studi di Siena
25011915 34 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.EBI Seoul National University
24948568 41 2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.EBI Seoul National University
25052206 43 Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.EBI University of Shizuoka
25467164 20 Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.EBI Roseman University of Health Sciences
25455494 172 Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.EBI Sapienza Universit£ di Roma
24884675 70 Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.EBI Genomics Institute of the Novartis Research Foundation
24835202 68 Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.EBI AstraZeneca
23865723 338 Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.EBI Arena Pharmaceuticals
24484240 19 Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.EBI University of Shizuoka
24321344 16 Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands.EBI Seoul National University
24055075 42 Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.EBI Glenmark Pharmaceuticals Ltd.
24035514 59 TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.EBI Seoul National University
23981530 46 The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.EBI Seoul National University
23886683 54 The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.EBI GlaxoSmithKline
23685943 123 2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.EBI Seoul National University
23632270 17 Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.EBI Toray Industries, Inc.
23474898 161 Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.EBI Sapienza Universit£ di Roma
23384387 4 Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic pro-opiomelanocortin (POMC) and/or decreased neuropeptide Y (NPY).EBI Hebrew University of Jerusalem
23206861 113 Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.EBI Sapienza Universit£ di Roma
21723725 31 Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.EBI Merck Research Laboratories
21435873 23 Identification of potent, soluble, and orally active TRPV1 antagonists.EBI MSD
20381363 13 In vitro TRPV1 activity of piperine derived amides.EBI Universidad de Antioquia
22957803 156 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.EBI Seoul National University
23058884 27 Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists.EBI AstraZeneca
22939234 31 Potent and orally efficacious benzothiazole amides as TRPV1 antagonists.EBI AstraZeneca
22169633 47 N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region.EBI Seoul National University
22525313 30 Tetrahydro-naphthols as orally available TRPV1 inhibitors.EBI Bayer Yakuhin, Ltd
20570528 34 Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.EBI Abbott Laboratories
20356305 151 Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.EBI Ferrara University
20307063 24 Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.EBI Neurogen Corporation
19951840 10 Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.EBI Universit£ del Piemonte Orientale
18424134 114 New tetrazole-based selective anandamide uptake inhibitors.EBI Sapienza Universit£ di Roma
18359227 68 N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).EBI Johnson& Johnson Pharmaceutical Research and Development
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18299195 24 4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.EBI Amgen Inc.
17046253 13 Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.EBI Universit£ del Piemonte Orientale
8759633 20 Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity.EBI Institute
11934585 8 Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.EBI Johnson& Johnson Pharmaceutical Research and Development
22257892 60 Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.EBI Sapienza Universit£ di Roma
22172309 12 Novel bioactive metabolites of dipyrone (metamizol).EBI Philipps-Universit£t
21902175 24 Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).EBI Universita` del Piemonte Orientale
21524089 8 Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria.EBI University of Utah
21531136 69 Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence.EBI Bayer Yakuhin, Ltd
21315587 35 Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.EBI Abbott Laboratories
21236666 32 Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists.EBI Department of Chemistry, MSD, Newhouse, Lanarkshire, UK. ronnie.palin@gmail.com
20932750 65 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.EBI Johnson& Johnson Pharmaceutical Research and Development LLC
20947352 57 Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development LLC
20855211 91 Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.EBI Abbott Laboratories
20615696 28 Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.EBI Neurogen Corporation
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
20457518 22 Discovery of TRPV1 antagonist ABT-116.EBI Abbott Laboratories
20378345 72 (-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.EBI Sapienza Universit£ di Roma
19875281 73 Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.EBI Sapienza Universit£ di Roma
 3 Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptorEBI TBA
19114307 19 Spiro-piperidine azetidinones as potent TRPV1 antagonists.EBI Schering-Plough Research Institute
19038548 119 Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
18809334 21 Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).EBI National Institute of Diabetes and Digestive and Kidney Diseases
18809327 6 Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.EBI GlaxoSmithKline
18722778 32 Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.EBI Abbott Laboratories
18662879 54 Discovery of piperidine carboxamide TRPV1 antagonists.EBI Johnson & Johnson Pharmaceutical Research and Development
18662872 43 Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.EBI Neurogen Corporation
18386885 52 Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.EBI Amgen, Inc.
14987072 1 Biologically active compounds from Aphyllophorales (polypore) fungi.EBI The University of Mississippi
18183945 39 Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.EBI Abbott Laboratories
18155908 89 Synthesis of benzamide derivatives as TRPV1 antagonists.EBI Pfizer Global Research & Development
17919904 5 Synthesis of aromatic compounds containing a 1,1-dialkyl-2-trifluoromethyl group, a bioisostere of the tert-alkyl moiety.EBI Pfizer Global Research & Development
17892935 56 Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.EBI Johnson & Johnson Pharmaceutical Research and Development
17489570 39 The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.EBI GlaxoSmithKline
16870426 126 From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.EBI Neurogen Corporation
16806913 6 N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.EBI GlaxoSmithKline
16570929 29 Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.EBI Farmaceutiche
16563760 24 The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.EBI Merck Sharp & Dohme
16420034 28 Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.EBI Novartis Institutes for Biomedical Research
16134949 50 Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.EBI Seoul National University
16000002 22 The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.EBI Farmaceutiche
15771431 85 Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
15664844 27 4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists.EBI Purdue Pharma LP
15634002 126 Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.EBI Amgen Inc.
15482915 104 Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.EBI Purdue Pharma L.P.
15149643 57 N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.EBI Johnson & Johnson Pharmaceutical Research and Development
14698197 35 7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1.EBI Johnson & Johnson Pharmaceutical Research and Development
12438527 3 Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.BDB Merck Sharp and Dohme
19361197 54 Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.BDB Universita del Piemonte Orientale
18027904 78 New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.BDB University of Rome La Sapienza
17585750 63 Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.BDB Amgen
17585749 56 Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.BDB Amgen
16580202 21 Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.BDB GSK
15203132 23 Discovery of small molecule antagonists of TRPV1.BDB GSK
17660385 13 [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.BDB Abbott Laboratories
16621571 29 Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.BDB Abbott Laboratories
15689158 21 Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.BDB Abbott Laboratories
17507218 28 Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.BDB Abbott Laboratories
17583335 49 In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.BDB Abbott Laboratories