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67 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27159637 8 Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa.EBI TBA
25850459 46 Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).EBI TBA
24794110 36 a-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists.EBI Seoul National University
23981530 46 The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.EBI Seoul National University
22796184 53 The SAR analysis of TRPV1 agonists with thea-methylated B-region.EBI Seoul National University
22169633 47 N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region.EBI Seoul National University
22546668 30 Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism.EBI Seoul National University
21111618 20 Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands.EBI Seoul National University
20356305 151 Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.EBI Ferrara University
20307063 24 Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.EBI Neurogen Corporation
19135377 31 Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists.EBI Seoul National University
18299195 24 4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.EBI Amgen Inc.
16759115 168 Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.EBI Amgen Inc.
12672252 104 Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.EBI Universidad Complutense
11741470 40 Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.EBI Universidad Complutense
8759633 20 Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity.EBI Institute
8709128 11 Similarities and differences in the structure-activity relationships of capsaicin and resiniferatoxin analogues.EBI Institute for Medical Research
10571146 19 3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.EBI Seoul National University
22227463 90 2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.EBI Shenyang Pharmaceutical University
21950613 31 Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.EBI Institut de Qu£mica Avan£ada de Catalunya
21531136 69 Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence.EBI Bayer Yakuhin, Ltd
20932750 65 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.EBI Johnson& Johnson Pharmaceutical Research and Development LLC
20947352 57 Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development LLC
20937561 67 Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.EBI Seoul National University
20615696 28 Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.EBI Neurogen Corporation
20457518 22 Discovery of TRPV1 antagonist ABT-116.EBI Abbott Laboratories
19931463 20 Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.EBI Sookmyung Women's University
19897373 27 Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists.EBI Seoul National University
19398205 29 Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.EBI Seoul National University
19038548 119 Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
18809334 21 Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).EBI National Institute of Diabetes and Digestive and Kidney Diseases
18809327 6 Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.EBI GlaxoSmithKline
18722778 32 Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.EBI Abbott Laboratories
18722118 22 Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.EBI Amgen Inc.
18662872 43 Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.EBI Neurogen Corporation
18406014 16 Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.EBI Seoul National University
18386885 52 Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.EBI Amgen, Inc.
18243423 1 Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents.EBI Central Drug Research Institute
18155908 89 Synthesis of benzamide derivatives as TRPV1 antagonists.EBI Pfizer Global Research & Development
17985859 16 Design and synthesis of indole-based peptoids as potent noncompetitive antagonists of transient receptor potential vanilloid 1.EBI University of Barcelona
17937985 54 Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.EBI Amgen Inc.
17851073 36 Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.EBI Amgen Inc.
17489570 39 The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.EBI GlaxoSmithKline
17035013 70 Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.EBI Seoul National University
16870426 126 From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.EBI Neurogen Corporation
16563760 24 The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.EBI Merck Sharp & Dohme
16420034 28 Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.EBI Novartis Institutes for Biomedical Research
16134949 50 Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.EBI Seoul National University
16005215 39 Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.EBI Seoul National University
15993063 50 Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.EBI Seoul National University
15771431 85 Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.EBI Johnson & Johnson Pharmaceutical Research and Development L.L.C.
15664827 18 Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands.EBI Seoul National University
15081027 38 Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.EBI Seoul National University
14505681 63 4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.EBI Purdue Pharma L.P.
12825950 43 N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.EBI Seoul National University
12438527 3 Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.BDB Merck Sharp and Dohme
12237342 2 High affinity antagonists of the vanilloid receptor.BDB National Cancer Institute
17585751 48 Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.BDB Amgen
17585750 63 Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.BDB Amgen
17585749 56 Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.BDB Amgen
15689158 21 Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.BDB Abbott Laboratories
17629487 20 Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.BDB Seoul National University
18072720 30 Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-Benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues.BDB Seoul National University