Search by Compound Name
Compounds Sorted by Binding Targets per Compound
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 2930 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 73 74 75 76 77 79 81 84 86 89 95
96 100 108 109 120 124 130 137 143 154 156 168 186 224 240 259 276 278 284 303
304 310 315 323 339 369 370 371 372 373 374 375 376 377 378 380 381 383 384
385 386 388 389 390 391 392 393 394 395 397 398 401 403 404 406 408 418 427
429 443 447 515
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Binding Targets
Enz. Inhib. Data
ITC Data
Alternate Compound Names
- Acetylcholinesterase
- Acyl-CoA: cholesterol acyltransferase (ACAT)
- Carboxylesterase 1
- Caspase-3
- Cholinesterases
- Chorismate mutase (MTB CM)
- Factor XIIa
- Human rhinovirus A protease
- Transthyretin
- 1-methyl-2,3-dihydro-1H-indole-2,3-dione
- CHEMBL60569
- Isatin analog 8
- N‐methylindol‐2,3‐dione (Compound 2)
- Coagulation factor X
- Coagulation factor XI
- Complement C1r subcomponent
- Complement C1s
- Factor XIIa
- Plasma kallikrein
- Plasminogen
- Transcription initiation factor IIA
- Vitamin K-dependent protein C
10 Ki
- US8598206, Table 6, 24
- 72 kDa type IV collagenase
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Collagenase (ChC)
- Interstitial collagenase
- Matrix metalloproteinase 12
- Matrix metalloproteinase-9
- Neutrophil collagenase
- (2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide
- Hydroxamate 24
- N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate
- 72 kDa type IV collagenase
- Aldehyde dehydrogenase 1A1
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Collagenase (ChC)
- Interstitial collagenase
- Matrix metalloproteinase-9
- Neutrophil collagenase
- CHEMBL98328
- Hydroxysulfonamide 46
- N-hydroxymethanesulfonamide
- 72 kDa type IV collagenase
- Aldehyde dehydrogenase 1A1
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Collagenase (ChC)
- Interstitial collagenase
- Matrix metalloproteinase-9
- Neutrophil collagenase
- CHEMBL55310
- Hydroxysulfonamide 53
- N-hydroxybenzenesulfonamide
- β-Carbonic anhydrase 2 (CA 2)
- β-Carbonic anhydrase 3 (CA 3)
- Astrosclerin-3
- Carbonic Anhydrase (mtCA 1)
- Carbonic Anhydrase III
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Carbonic anhydrase 9
15 Ki
- β-CA inhibitor, 10
- 4-Amino-3,5-dibromobenzenesulfonamide
- 4-amino-3,5-dibromobenzene-1-sulfonamide
- CHEMBL306195
- halogenosulfanilamide deriv. 12
- MurA (E. coli)
- MurB (E. coli)
- MurB (S. aureus)
- MurC
- MurC (S. aureus)
- MurD
- MurD (S. aureus)
- MurE
- MurE (E. coli)
9 IC50
- MurA/B/C/D/E inhibitor (compound 67)
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C9
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
- MAP kinase ERK1
- Mitogen-activated protein kinase 1
- Potassium voltage-gated channel subfamily H member 2
- US8697715, 1
- US9259470, 1
- Cytochrome P450 1A
- Cytochrome P450 2A6
- Cytochrome P450 2B6
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 2E1
- Cytochrome P450 3A
- 3-(pyridin-3-yl)prop-2-yn-1-amine
- CHEMBL360541
- US8609708, 3
- nicotine 3-heteroaromatic analogue 3a
- Carbonic Anhydrase IV
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Carbonic anhydrase 9
- Cyclooxygenase
- Cyclooxygenase-1 (COX-1)
- Prostaglandin E synthase/G/H synthase 2
- Prostaglandin G/H synthase (Cyclooxygenase-2)
- Prostaglandin G/H synthase (cyclooxygenase)
23 IC50
- 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
- CHEMBL26915
- SC-560
- Carbonic Anhydrase III
- Carbonic Anhydrase XIV
- Carbonic anhydrase
- Carbonic anhydrase 1
- Carbonic anhydrase 13 (CA XIII)
- Carbonic anhydrase 2
- Carbonic anhydrase 6 (CA-VI)
- Carbonic anhydrase V
- Carbonic anhydrases; II & IX
- 2,4-dichloro-5-sulfamoylbenzoic acid
- 2000-01951
- Lasamide (Hsba)
- LeadQuest Compound 9
- Protein-Tyrosine Phosphatase 1B (PTP1B)
- Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (G117E)
- Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (L119V)
- Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (M114V)
- Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113I)
- Protein-Tyrosine Phosphatase 1B (PTP1B) Mutant (V113L/M114V)
- Protein-tyrosine phosphatase 1B
- T-Cell Protein-Tyrosine Phosphatase (TCPTP) Mutant (V121L)
- Tyrosine-protein phosphatase non-receptor type 2
10 IC50
- ({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(methoxycarbonyl)phenyl]-5-phenylpent-4-en-1-yl]phenyl}difluoromethyl)phosphonic acid
- benzotriazole phenyldifluoromethylphosphonic acid compound 1
- Coagulation factor X
- Hepsin
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin
- Trypsin-1
- Urokinase (uPA) Mutant (S190A)
- Urokinase-type plasminogen activator
14 Ki
- 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate
- 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE)
- APC-8696
- CA-04
- CRA-8696
- Coagulation factor X
- Hepsin
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin
- Trypsin-1
- Urokinase (uPA) Mutant (S190A)
- Urokinase-type plasminogen activator
14 Ki
- 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE
- APC-10302
- CA-14
- CRA-10302
- {amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium
- Coagulation factor X
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin
- Trypsin-1
- Tryptase
- Urokinase (uPA) Mutant (S190A)
- Urokinase-type plasminogen activator
12 Ki
- 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate
- CA-09
- CRA-10818
- Coagulation factor X
- Hepsin
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin-1
- Tryptase
- Urokinase (uPA) Mutant (S190A)
- Urokinase-type plasminogen activator
10 Ki
- 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-{[(1S,2S)-2-methylcyclohexyl]oxy}benzen-1-olate
- CA-11
- CRA-11092
- Coagulation factor X
- Hepsin
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin-1
- Tryptase
- Urokinase (uPA) Mutant (S190A)
- Urokinase-type plasminogen activator
10 Ki
- CA-22
- [amino({4-[(3-hydroxynaphthalene-2-)amido]phenyl}amino)methylidene]azanium
- Coagulation factor VII
- Coagulation factor X
- Plasma kallikrein
- Plasminogen
- Prothrombin
- Tissue-type plasminogen activator
- Trypsin
- Urokinase-type plasminogen activator
- Vitamin K-dependent protein C
10 Ki
- (2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimidoyl-3-hydroxyphenyl)amino]-2-(3,5-diethoxy-2-fluorophenyl)acetamide
- G17905
- R-4-[2-(3-aminobenzenesulfonylamino)-1-(3,5-diethoxy-2-fluorophenyl)-2-oxoethylamino]-2-hydroxy-benzamidine.TFA
- Beta-secretase 1
- Beta-secretase 2
- Cathepsin D
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- Potassium voltage-gated channel subfamily H member 2
11 IC50
- US8962616, 1
- Beta-secretase 1
- Beta-secretase 2
- Cathepsin D
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- Potassium voltage-gated channel subfamily H member 2
13 IC50
- US8962616, 22
- US8962616, 4
- Cereblon/Histone deacetylase 6
- Histone deacetylase
- Histone deacetylase 1
- Histone deacetylase 10
- Histone deacetylase 11
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 8
- Histone deacetylase 8 (HDAC8)
12 IC50
1 ΔG°
- Thiol-SAHA (t-SAHA)
- CDK2/CycE
- CDK7/Cyclin H/MNAT1
- Cyclin-Dependent Kinase 1 (CDK1)
- Cyclin-Dependent Kinase 2 (CDK2)
- Cyclin-Dependent Kinase 4 (CDK4)
- Cyclin-Dependent Kinase 5 (CDK5)
- Cyclin-Dependent Kinase 9 (CDK9)
- Cyclin-dependent kinase 2
- Serine/threonine-protein kinase TBK1
9 IC50
- Oxindole (Scaffold V)
- Chromobox protein homolog 7 (CBX7)
- E3 ubiquitin-protein ligase (UHRF1)
- Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
- Lysine-specific demethylase 5A
- MBT domain-containing protein 1 (MBTD1)
- Methyl-lysine binding protein (53BP1)
- PHD finger protein 1 (PHF1)
- PHD finger protein 19 (PHF19)
- PHD finger protein 23 (PHF23)
9 IC50
- 3-Bromo-N-(3-(dimethylamino)propyl)benzamide (2)
- Chromobox protein homolog 7 (CBX7)
- E3 ubiquitin-protein ligase (UHRF1)
- Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
- Lysine-specific demethylase 5A
- MBT domain-containing protein 1 (MBTD1)
- Methyl-lysine binding protein (53BP1)
- PHD finger protein 1 (PHF1)
- PHD finger protein 19 (PHF19)
- PHD finger protein 23 (PHF23)
9 IC50
- 3-Bromo-N-(3-(isopropylamino)propyl)benzamide (3)
- Chromobox protein homolog 7 (CBX7)
- E3 ubiquitin-protein ligase (UHRF1)
- Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
- Lysine-specific demethylase 5A
- MBT domain-containing protein 1 (MBTD1)
- Methyl-lysine binding protein (53BP1)
- PHD finger protein 1 (PHF1)
- PHD finger protein 19 (PHF19)
- PHD finger protein 23 (PHF23)
9 IC50
- 3-Bromo-N-(3-(tert-butyl(methyl)amino)propyl)benzamide (UNC2892, 4)
- Chromobox protein homolog 7 (CBX7)
- E3 ubiquitin-protein ligase (UHRF1)
- Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
- Lysine-specific demethylase 5A
- MBT domain-containing protein 1 (MBTD1)
- Methyl-lysine binding protein (53BP1)
- PHD finger protein 1 (PHF1)
- PHD finger protein 19 (PHF19)
- PHD finger protein 23 (PHF23)
9 IC50
- 3-Bromo-N-(3-(tert-butoxy)propyl)benzamide (5)
- Chromobox protein homolog 7 (CBX7)
- E3 ubiquitin-protein ligase (UHRF1)
- Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
- Lysine-specific demethylase 5A
- MBT domain-containing protein 1 (MBTD1)
- Methyl-lysine binding protein (53BP1)
- PHD finger protein 1 (PHF1)
- PHD finger protein 19 (PHF19)
- PHD finger protein 23 (PHF23)
9 IC50
- 3-Bromo-N-(3-(pyrrolidin-1-yl)propyl)benzamide (6)
- Cytochrome P450 1A
- Cytochrome P450 1A1
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 2D6 (2D6)
- H3K27me2
- H3K27me3
12 IC50
- US10098888, Compound 1
- US9006242, 1
- Cytochrome P450 1A
- Cytochrome P450 1A1
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 2D6 (2D6)
- H3K27me2
- H3K27me3
12 IC50
- US10098888, Compound 2
- US9006242, 2
- Acyl-protein thioesterase 1/2
- Dipeptidyl peptidase 2 (DPP II)
- Dipeptidyl peptidase 4
- Dipeptidyl peptidase 8/9
- Dipeptidyl peptidase 9
- Dipeptidyl peptidase VIII
- Dipeptidyl peptidase-IV (DDP-4)
- Fibroblast activation protein alpha
- Lysosomal phospholipase A1
- 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile
- 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile
- Alogliptin
- SYR-322
- Cytoplasmic tyrosine-protein kinase BMX
- Receptor protein-tyrosine kinase erbB-4
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase Lck
- Tyrosine-protein kinase TEC
- Tyrosine-protein kinase TXK
15 IC50
- US10604504, Example 5
- US9688629, 5
- US9802915, Example 22
- US9920031, Example 5
- Rhomboid protease (AaROM)
- Rhomboid protease (BsYqgP)
- Rhomboid protease (HiGlpG)
- Rhomboid protease (MmRHBDL1)
- Rhomboid protease (MmRHBDL3)
- Rhomboid protease (PhROM)
- Rhomboid protease (PsAarA)
- Rhomboid protease (TmROM)
- Rhomboid protease (VcROM)
9 IC50
- 4‐Chloro‐7‐nitro‐3‐[(5‐phenylpentyl)oxy]isochromen‐1‐one (21)
- Cytoplasmic tyrosine-protein kinase BMX
- Receptor protein-tyrosine kinase erbB-4
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase Lck
- Tyrosine-protein kinase TEC
- Tyrosine-protein kinase TXK
14 IC50
- US10604504, Example 34
- US9688629, 34
- US9802915, Example 34
- US9920031, Example 34
- ERK2(L114A)
- ERK2(L198A/L232A)
- ERK2(L198A/L235A)
- ERK2(L232A)
- ERK2(L235A)
- ERK2(L265A)
- ERK2(R275A)
- ERK2(Y191A)
- Mitogen-activated protein kinase 1
9 Kd
- US9115122, 2.3.2
- Cereblon/Histone deacetylase 6
- Histone deacetylase 1
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 8
- Histone deacetylase 9
- BRD2492
- Alkaline phosphatase, tissue-nonspecific isozyme
- Intestinal alkaline phosphatase
- Intestinal alkaline phosphatase (IAP)
- L-type amino acid transporter 1
- Large neutral amino acids transporter small subunit 1
- Phospholipase A-2-activating protein
- Tissue non-specific alkaline phosphatase (TNAP)
- Voltage-gated calcium channel alpha2/delta subunit 1
- X-linked inhibitor of apoptosis protein (XIAP)
2 ΔG°
- (2S)-2-amino-3-phenylpropanoic acid
- CHEMBL301523
- L-[2,3,4,5,6-3H]phenylalanine
- L-phenylalanine
- Phenylalanine
- β-galactosidase
- Acidic alpha-glucosidase
- Glucosylceramidase
- Lactase-glycosylceramidase
- Lysosomal acid glucosylceramidase
- Trehalase
- Uncharacterized protein
- alpha-Glucosidase (α-Glucosidase)
- alpha-Glucosidase (alpha-Glu)
- (2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol
- alpha-1-C-Butyl-DNJ
- Aminoacyl-tRNA synthetase
- Anthrax Lethal Factor (LF)
- Bile salt export pump
- Human immunodeficiency virus type 1 REV
- Phosphatidylcholine specific phospholipase C, PC-PLC
- Phosphatidylcholine-retinol O-acyltransferase
- Phosphoinositide specific phospholipase C, PI-PLC
- RNA(23-mer)
- Vascular endothelial growth factor receptor 2
9 ΔG°
- (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol
- KDR Kinase Inhibitor, 3
- Neomycin
- Neomycin B
- Cytochrome P450 1A
- Cytochrome P450 2B6
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 2E1
- Cytochrome P450 3A
- Cytochrome P450 3A5
9 IC50
- US9180183, SC12
- Nitric Oxide Synthase, brain Mutant (D597N)
- Nitric Oxide Synthase, endothelial
- Nitric Oxide Synthase, inducible
- Nitric oxide synthase mutant (nNOS M336V/D597N)
- Nitric oxide synthase, brain
- Nitric oxide synthase, endothelial
- Nitric oxide synthase, inducible
- Nitric-oxide synthase, brain
- Nitric-oxide synthase, endothelial
15 Ki
- US10759791, Compound 14g
- nNOS inhibitor, 3
- Nitric Oxide Synthase, brain Mutant (D597N)
- Nitric Oxide Synthase, endothelial
- Nitric Oxide Synthase, inducible
- Nitric oxide synthase mutant (nNOS M336V/D597N)
- Nitric oxide synthase, brain
- Nitric oxide synthase, endothelial
- Nitric oxide synthase, inducible
- Nitric-oxide synthase, brain
- Nitric-oxide synthase, endothelial
15 Ki
- US10759791, Compound 14h
- nNOS inhibitor, 4
- Nitric Oxide Synthase, brain Mutant (D597N)
- Nitric Oxide Synthase, endothelial
- Nitric Oxide Synthase, inducible
- Nitric oxide synthase mutant (nNOS M336V/D597N)
- Nitric oxide synthase, brain
- Nitric oxide synthase, endothelial
- Nitric oxide synthase, inducible
- Nitric-oxide synthase, brain
- Nitric-oxide synthase, endothelial
- US10759791, Compound 14j
- nNOS inhibitor, 5
- Nitric Oxide Synthase, brain Mutant (D597N)
- Nitric Oxide Synthase, endothelial
- Nitric Oxide Synthase, inducible
- Nitric oxide synthase mutant (nNOS M336V/D597N)
- Nitric oxide synthase, brain
- Nitric oxide synthase, endothelial
- Nitric oxide synthase, inducible
- Nitric-oxide synthase, brain
- Nitric-oxide synthase, endothelial
15 Ki
- US10759791, Compound 14k
- nNOS inhibitor, 6
- Bromodomain-containing protein 4
- Cereblon/Histone deacetylase 1
- Cereblon/Histone deacetylase 4
- Cereblon/Histone deacetylase 6
- Histone Deacetylase 6 (HDAC6)
- Histone deacetylase 1
- Histone deacetylase 2
- Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
- Histone deacetylase 4
15 IC50
- (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
- Antibiotic FR 901228
- CHEMBL343448
- Depsipeptide
- FK228
- Romidepsin
- Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
- Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
- Lysine-specific demethylase 5A (KDM5A(aa 1-739)ΔAP(2C-2S))
- Lysine-specific demethylase 5B
- Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
- Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
- Lysine-specific demethylase 5C
- Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
- Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
- 3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (N16)
- Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
- Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
- Lysine-specific demethylase 5A (KDM5A(aa 1-739)ΔAP(2C-2S))
- Lysine-specific demethylase 5B
- Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
- Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
- Lysine-specific demethylase 5C
- Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
- Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
- methyl 4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-4-carboxylate (N4)
- Acetate Operon Repressor (C-IclR)
- Acetate Operon Repressor (IclR)
- Alpha-ketoglutarate-dependent dioxygenase FTO
- C-terminal-binding protein 2
- Monocarboxylate transporter 2
- Prolyl 4-hydroxylase
- Prostaglandin Transporter
- Solute carrier family 22 member 20
- Solute carrier family 22 member 6
2 ΔG°
- 2-Oxopropanoate
- 2-oxopropanoic acid
- Pyruvate
- Cytochrome P450 1A
- Cytochrome P450 2B6
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Glutamate receptor ionotropic, NMDA 2B
- Melanin-concentrating hormone receptor 2/HERG
- US9221796, 46, P-4
- Liver X Receptor alpha (LXR-alpha)
- Liver X Receptor beta (LXR-beta)
- Nuclear receptor subfamily 1 group I member 2
- Oxysterols receptor LXR-alpha
- Oxysterols receptor LXR-beta
- Replicase polyprotein 1ab
- alpha-Glucosidase (alpha-Glu)
- lxralpha
- lxrbeta
- 2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-[2,2-di(phenyl)ethyl]amino]propoxy]phenyl]acetic acid
- 2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid
- CHEMBL59030
- GSK-3965
- GW3965
- US10543183, Compound GW3965
- US10669296, Compound GW3965
- Coagulation factor X
- Complement factor B (FB) catalytic domain
- Complement factor D
- Complement factor D (FD) catalytic domain (Human fD)
- Kalligrein-7 Y180R (KLK7)
- Kallikrein 5
- Kallikrein 7
- Leukocyte elastase
- Prothrombin
13 IC50
- Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carbamoyl)pyrrolidine-1-carboxamido)-methyl)benzoate (2)
- Adenosine Receptors A2a (A2a)
- Adenosine receptor
- Adenosine receptor A1
- Adenosine receptor A2a
- Adenosine receptor A2a and A3
- Adenosine receptor A2b
- Adenosine receptor A3
- Adenosine receptors; A2a & A2b
- D(2) dopamine receptor
- 4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol
- CHEMBL113142
- ZM 241385
- ZM241385
- [3H]-ZM241385
- Caseinolytic protein C1 (ClpC1 NTD E89A)
- Caseinolytic protein C1 (ClpC1 NTD E89Q)
- Caseinolytic protein C1 (ClpC1 NTD F2A)
- Caseinolytic protein C1 (ClpC1 NTD F2Y)
- Caseinolytic protein C1 (ClpC1 NTD F80A)
- Caseinolytic protein C1 (ClpC1 NTD F80Y)
- Caseinolytic protein C1 (ClpC1 NTD)
- Caseinolytic protein C1 (ClpC1 NTD-D1)
- Caseinolytic protein C1 (ClpC1)
9 Kd
9 ΔG°
- Cyclomarin A1 (CymA1)
- Cytochrome P450 2C9
- Cytochrome P450 3A
- Sodium channel alpha subunit
- Sodium channel alpha subunits; brain (Types I, II, III)
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel protein type 9 subunit alpha
- Sodium channel protein type IX alpha subunit
- Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
16 IC50
- US9212182, 672
- Neuronal acetylcholine receptor
- Neuronal acetylcholine receptor Alpha-2/Beta-4
- Neuronal acetylcholine receptor Alpha-3/Beta-2
- Neuronal acetylcholine receptor Alpha-3/Beta-4
- Neuronal acetylcholine receptor Alpha-4/Beta-2
- Neuronal acetylcholine receptor protein alpha-2/beta-2 subunit
- Neuronal acetylcholine receptor protein alpha-4/beta-4 subunit
- Neuronal acetylcholine receptor; alpha3/beta4
- nAChR alpha4 beta2 subtype
- US9284322, varenicline
- US9303017, Varenicline
- Bile salt export pump
- Canalicular multispecific organic anion transporter 1
- Canalicular multispecific organic anion transporter 2
- Caspase-1
- Caspase-3
- Caspase-4
- Caspase-5
- Caspase-9
- Multidrug resistance-associated protein 4
9 IC50
- Felbinac
- 12-Lipoxygenase (12-LOX)
- 5-Lipoxygenase
- Androgen Receptor
- Arachidonate 15-lipoxygenase
- Arachidonate 5-lipoxygenase
- Cyclooxygenase
- Cytochrome P450 19A1
- Insulin-like growth factor I receptor
- Lipoxygenase-1
- 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
- 4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol
- CHEMBL313972
- Masoprocol
- NDGA
- Nordihydroguaiaretic Acid
- 1,3-beta-glucan synthase component GLS2
- Baculoviral IAP repeat-containing protein 2/Estrogen receptor
- Estrogen receptor
- Estrogen-Related Receptor, gamma
- Estrogen-related receptor alpha
- Estrogen-related receptor beta
- Estrogen-related receptor gamma
- Steroid hormone receptor ERR2
- von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
21 IC50
- 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hydroxy-2-phenylpent-1-en-1-yl]phenol
- 4-hydroxytamoxifen (4-OHT) analog, 15
- GSK 5182
- Acetylcholinesterase
- Acyl-CoA: cholesterol acyltransferase (ACAT)
- Androgen receptor
- Carboxylesterase 1
- Cathepsin B
- Cholinesterases
- Factor XIIa
- Indoleamine 2,3-dioxygenase
- Papain
- Benzophenone
- CHEMBL90039
- diphenylmethanone
- ATP-citrate synthase
- Cell cycle histidine kinase CckA
- Heat Shock Protein 90 (Hsp90)
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- Heat-shock protein 90 (Hsp90)
- Virulence sensor histidine kinase PhoQ
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
- Radicicol
- Bile salt export pump
- Canalicular multispecific organic anion transporter 1
- Canalicular multispecific organic anion transporter 2
- Multidrug resistance-associated protein 4
- P-gp nanodisc·BD-verapamil
- P-gp nanodisc·BD-vinblastine
- Proteasome Macropain subunit
- Proteasome component C5
- Proteasome subunit beta type-1/beta type-5
13 IC50
- Vinblastine
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 D144A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 D145A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 I146A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 L94A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 M149A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 P82A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 W81A)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 WT)
- Bromodomain protein 4 bromodomain 1 (BRD4 BD1 Y139F)
9 Kd
- Histone H4 (1-25)
- MSGRGKGGKGLGKGGAKRHRKVLRD
- Acetylcholinesterase
- Acyl-CoA: cholesterol acyltransferase (ACAT)
- Aldehyde dehydrogenase 1A1 (ALDH1A1)
- Aldehyde dehydrogenase 3A1 (ALDH3A1)
- Aldehyde dehydrogenase, mitochondrial
- Carboxylesterase 1
- Cholinesterases
- Factor XIIa
- Muscarinic acetylcholine receptor M1
- 1-benzyl-2,3-dihydro-1H-indole-2,3-dione
- Isatin-based compound, 14
- Acetylcholinesterase
- Acyl-CoA: cholesterol acyltransferase (ACAT)
- Cholinesterases
- Factor XIIa
- MSRA protein
- Phospholipase C, gamma 1
- Phospholipase C-beta-3
- Trypanosoma brucei RNA editing ligase 1
- tyrosyl-DNA phosphodiesterase 2
- 1,2-Dione-Based Compound, 17
- 5,6-dihydro-1=10-phenantroline-5,6-dione
- cid_72810
- Carbonic anhydrase 1
- Carbonic anhydrase 12
- Carbonic anhydrase 2
- Carbonic anhydrase 9
- HIV-1 Integrase
- Hepatitis C virus NS5B RNA-dependent RNA polymerase
- Human immunodeficiency virus type 1 integrase
- Integrase
- Reverse transcriptase
- 4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-dioxobutanoic acid
- CHEMBL421353
- CHEMBL50605
- L-731988
- Beta-secretase 1
- Cathepsin D
- Cathepsin E
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- Plasmepsin 2
- Plasmepsin 4 (PM-IV)
11 IC50
- US9353089, 117
- Arachidonate 5-lipoxygenase
- Cyclooxygenase
- Cytochrome P450 1A
- Cytochrome P450 2A5
- Cytochrome P450 2A6
- DNA repair and recombination protein (RadA)
- MAP kinase-activated protein kinase 2
- Transcriptional Regulator TtgR
- Uridine-5'-diphosphoglucuronosyltransferase 1A1
2 ΔG°
- 1-Naphthalenol
- 1-Naphthol
- CHEMBL122617
- Naphth-1-ol, 9
- alpha-naphthol
- naphthalen-1-ol
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Serine/threonine-protein kinase PIM
- Serine/threonine-protein kinase pim-1
- Serine/threonine-protein kinase pim-2
- Serine/threonine-protein kinase pim-3
- US9394297, 450
- Alpha-1A adrenergic receptor
- Aminopeptidase N
- Bacterial leucyl aminopeptidase
- Cytosol aminopeptidase
- Leukotriene A4 hydrolase
- Phenylethanolamine N-methyltransferase
- Serotonin 2 (5-HT2) receptor
- Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
- Urokinase-type plasminogen activator
- (2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine
- 1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
- CHEMBL30294
- Tetrahydronaphthalen-2-amine, 3a
- Serine protease NS3-NS5B
- Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
- Serine protease NS5A (L28T)
- Serine protease NS5A (L31F)
- Serine protease NS5A (L31M)
- Serine protease NS5A (L31V)
- Serine protease NS5A (R30H)
- Serine protease NS5A (Y93C)
- Serine protease NS5A (Y93H)
19 EC50
- US9427428, 9
- US9433609, 9
- Serine protease NS3-NS5B
- Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
- Serine protease NS5A (L28T)
- Serine protease NS5A (L31F)
- Serine protease NS5A (L31M)
- Serine protease NS5A (L31V)
- Serine protease NS5A (R30H)
- Serine protease NS5A (Y93C)
- Serine protease NS5A (Y93H)
20 EC50
- US9427428, 3
- US9433609, 3
- Serine protease NS3-NS5B
- Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
- Serine protease NS5A (L28T)
- Serine protease NS5A (L31F)
- Serine protease NS5A (L31M)
- Serine protease NS5A (L31V)
- Serine protease NS5A (R30H)
- Serine protease NS5A (Y93C)
- Serine protease NS5A (Y93H)
20 EC50
- US9427428, 8
- US9433609, 8
- Serine protease NS3-NS5B
- Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
- Serine protease NS5A (L28T)
- Serine protease NS5A (L31F)
- Serine protease NS5A (L31M)
- Serine protease NS5A (L31V)
- Serine protease NS5A (R30H)
- Serine protease NS5A (Y93C)
- Serine protease NS5A (Y93H)
19 EC50
- US9427428, 13
- US9433609, 13
- Serine protease NS3-NS5B
- Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
- Serine protease NS5A (L28T)
- Serine protease NS5A (L31F)
- Serine protease NS5A (L31M)
- Serine protease NS5A (L31V)
- Serine protease NS5A (R30H)
- Serine protease NS5A (Y93C)
- Serine protease NS5A (Y93H)
19 EC50
- US9427428, 16
- US9433609, 16
- High affinity nerve growth factor receptor
- Mitogen-activated protein kinase kinase kinase 10
- Mitogen-activated protein kinase kinase kinase 11
- Mitogen-activated protein kinase kinase kinase 9
- Mitogen-activated protein kinase kinase kinase 9 (MLK1)
- Mixed Lineage Kinase 1 (MLK1)
- Mixed Lineage Kinase 3 (MLK3)
- Protein delta homolog 1
- Protein kinase C (PKC)
13 IC50
- CEP-1347
- CHEMBL290352
- methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)methyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate
- Cyclin-dependent kinase 2
- Dual-specificity tyrosine-phosphorylation regulated kinase 1A
- RAC-alpha serine/threonine-protein kinase
- Rho-associated protein kinase 1
- Rho-associated protein kinase 1 (ROCK I)
- Ribosomal protein S6 kinase (P70S6K)
- Ribosomal protein S6 kinase alpha 5
- Serine/threonine-protein kinase AKT
- Serine/threonine-protein kinase AKT2
10 IC50
- 4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine
- CHEMBL188434
- oxadiazole-containing compound, 9
- CDK2/Cyclin E/G1/S-specific cyclin E2
- Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
- Protein kinase C alpha type
- Vascular endothelial growth factor receptor 2
- p110α/p85α
19 IC50
- 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol
- 3-[4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-2-yl]phenol
- CHEMBL541643
- thieno[3,2-d]pyrimidine derivative, 1
- thienopyrimidine derivative, 1
- Cereblon/Histone deacetylase 6
- Histone Deacetylase 4 (HDAC4) Mutant (H976Y)
- Histone deacetylase 1
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 8
18 IC50
- 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide
- 4-phenylimidazole, 17
- CHEMBL407959
- Cereblon/Histone deacetylase 6
- Histone Deacetylase 4 (HDAC4) Mutant (H976Y)
- Histone deacetylase 1
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 8
- 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)nonyl]acetamide
- 4-phenylimidazole, 19
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C9
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- DNA-dependent protein kinase
- Potassium voltage-gated channel subfamily H member 2
- Serine/threonine-protein kinase mTOR
- p110α/p85α
9 IC50
- US9453031, 3
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C9
- Cytochrome P450 2D6 (2D6)
- Cytochrome P450 3A
- DNA-dependent protein kinase
- Potassium voltage-gated channel subfamily H member 2
- Serine/threonine-protein kinase mTOR
- p110α/p85α
9 IC50
- US9453031, 11
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 40
- US10150765, Example 40
- US10703749, Example 11
- US9464084, 40
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 74
- US10150765, Example 74
- US10703749, Example 74
- US9464084, 74
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 88
- US10150765, Example 88
- US10703749, Example 88
- US9464084, 88
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 148
- US10150765, Example 148
- US10703749, Example 148
- US9464084, 148
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Melanin-concentrating hormone receptor 2/HERG
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 220
- US10150765, Example 220
- US10703749, Example 220
- US9464084, 220
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Melanin-concentrating hormone receptor 2/HERG
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 228
- US10150765, Example 228
- US10703749, Example 228
- US9464084, 228
- 1,3-beta-glucan synthase component GLS2
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C8
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- P2X purinoceptor 7
- P2X purinoceptor 7 (P2X7)
- US10112937, Example 235
- US10150765, Example 235
- US10703749, Example 235
- US9464084, 235
- Aurora kinase A/Targeting protein for Xklp2
- Glucose 6-phosphate dehydrogenase (G6PD)
- MRCK alpha
- RAC-alpha serine/threonine-protein kinase
- Rho-associated protein kinase 1
- Rho-associated protein kinase 2
- Rho-kinase (ROCK II)
- cAMP-dependent protein kinase (PKA)
- glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
13 IC50
- N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
- cid_5056270
- pyridine-thiazole, 1
- Aromatic-L-amino-acid decarboxylase
- Bcl-2-like protein 1
- Cell division control protein 42 homolog
- Chain E, Fragment Double-D From Human Fibrin
- DNA Ligase I
- Group III secretory phopholipase A2
- Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1
- Regulator of G-protein signaling 17
- Reverse transcriptase
- 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium
- CHEMBL490129
- Pseudochelerythrine
- Veadent
- cid_5154
- sanguinarine
- sangvinarin
- ADRB2
- Beta-1 adrenergic receptor
- Beta-2 adrenergic receptor
- Beta-3 adrenergic receptor
- Beta-adrenergic receptor kinase 1
- Bile salt export pump
- Canalicular multispecific organic anion transporter 1
- Canalicular multispecific organic anion transporter 2
- Multidrug resistance-associated protein 4
- 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol
- 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol, 5
- Brethaire
- Brethine
- Bricanyl
- Terbutaline
- Terbutaline,(+/-)
- EGF-R Tyrosine Kinase Mutant (G719S)
- EGF-R Tyrosine Kinase Mutant (L858R)
- EGF-R Tyrosine Kinase Mutant (L858R/T790M)
- EGF-R Tyrosine Kinase Mutant (T790M)
- Epidermal growth factor receptor
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Tyrosine-protein kinase Yes
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 2
- 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- AEE788
- Beta-lactamase (TEM-1)
- Beta-lactamase AmpC
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
- Fatty-acid amide hydrolase 1
- Monoglyceride lipase
- Subtilisin
- beta-Carbonic Anhydrase
- (4-methoxyphenyl)boranediol
- CHEMBL21427
- Phenylboronic Acid, 12
- 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
- 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) Mutant (H222S)
- 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) Mutant (L306A)
- 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) Mutant (L308A)
- 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) Mutant (L54V)
- Aldehyde reductase
- Aldo-keto reductase family 1 member C1
- Aldo-keto reductase family 1 member C2
- Aldo-keto reductase family 1 member C4 (AK1C4)
- 3,5-dichloro-2-hydroxybenzoic acid
- 3,5-dichlorosalicylic acid
- CHEMBL449129
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
13 IC50
- (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide
- US10167276, Example 1
- US10654835, Example 1
- US9714236, 1
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
13 IC50
- (2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)propanamide
- US10167276, Example 10b
- US10654835, Example 10b
- US9714236, 10b
- 1,3-beta-glucan synthase component GLS2
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
13 IC50
- (2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7- yl)-2-(4-methylpiperazin-1- yl)propanamide
- US10167276, Example 25
- US10654835, Example 25
- US9714236, 25
- 1,3-beta-glucan synthase component GLS2
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
13 IC50
- (2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide
- US10167276, Example 34
- US10654835, Example 34
- US9714236, 34
- 1,3-beta-glucan synthase component GLS2
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
13 IC50
- (2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide
- US10167276, Example 37
- US10654835, Example 37
- US9714236, 37
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
13 IC50
- (2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}- 1H-indol-7-yl)-2- (4-methylpiperazin- 1-yl)butanamide
- US10167276, Example 49
- US10654835, Example 49
- US9714236, 49
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
13 IC50
- (2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide
- US10167276, Example 53
- US10654835, Example 53
- US9714236, 53
- JAK1 (aa 866-1154)
- JAK2 (aa 808-1132)
- JAK2 (aa 831-1132)
- JAK3 (aa 781-1124)
- JAK3 (aa 811-1124)
- Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase JAK1 (aa 866-1154)
- Tyrosine-protein kinase JAK2
- Tyrosine-protein kinase JAK3
13 IC50
- (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)butanamide
- US10167276, Example 62
- US10654835, Example 62
- US9714236, 62
- 12-Lipoxygenase (12-LOX)
- 15-Lipoxygenase-2 (15-LOX-2)
- Arachidonate 15-lipoxygenase
- Dipeptidyl peptidase 4
- Dipeptidyl peptidase III
- Enoyl-acyl-carrier protein reductase
- Multidrug resistance protein 1/Multidrug resistance associated protein 1
- Prolyl endopeptidase
- Serine/threonine-protein kinase pim-1
10 IC50
- 3,7-dihydroxy-2-phenyl-4H-chromen-4-one
- 3,7-dihydroxyflavone
- CHEMBL210276
- Abhydrolase Domain-Containing Protein 6
- Anandamide amidohydrolase
- Fatty-acid amide hydrolase 1
- KIAA1363
- Monoglyceride Lipase (MGL)
- Monoglyceride lipase
- Sn1-specific diacylglycerol lipase alpha
- Transient receptor potential cation channel subfamily A member 1
- Transient receptor potential cation channel subfamily V member 1
- CHEMBL509860
- LY2183240
- N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4-tetrazole-1-carboxamide
- Cytochrome P450 1A
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Sodium channel alpha subunit
- Sodium channel protein type 2 alpha subunit
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel protein type 9 subunit alpha
13 IC50
- N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazolo[4,3-a]-pyridin-3-yl)-cyclopropanesulfonamide
- US9550775, 1
- Cytochrome P450 1A
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- Sodium channel alpha subunit
- Sodium channel protein type 2 alpha subunit
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel protein type 9 subunit alpha
12 IC50
- N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]-triazolo[4,3-a]pyridin-3-yl)methanesulfonamide
- US9550775, 3
- Poly [ADP-ribose] polymerase 1
- Poly [ADP-ribose] polymerase 10
- Poly [ADP-ribose] polymerase 12
- Poly [ADP-ribose] polymerase 14
- Poly [ADP-ribose] polymerase 2
- Poly [ADP-ribose] polymerase 4
- Poly [ADP-ribose] polymerase tankyrase-1
- Poly [ADP-ribose] polymerase tankyrase-2
- Protein mono-ADP-ribosyltransferase PARP3
- 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
- VELIPARIB
- benzimidazole carboxamide, 3a
- Alpha-2A adrenergic receptor
- Alpha-2C adrenergic receptor
- HRH3
- Histamine H1 receptor
- Histamine H2 Receptor
- Histamine H3 receptor
- Histamine H4 receptor
- Histamine N-methyltransferase
- Serotonin (5-HT) receptor
- 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole
- CHEMBL14638
- CHEMBL1795025
- Ciproxifan
- 3',5'-cyclic phosphodiesterase
- 3-phosphoinositide dependent protein kinase-1
- Carbonic anhydrase
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- Carbonic anhydrase 9
- Poly [ADP-ribose] polymerase 1
- Purine nucleoside phosphorylase
- poly-ADP-ribose polymerase 2 (PARP2)
- 4-HQN
- 4-hydroxyquinazoline
- CHEMBL266540
- quinazolin-4-ol
- 72 kDa type IV collagenase
- Collagenase 3
- Interstitial collagenase
- Matrix metalloproteinase-12 (MMP12)
- Matrix metalloproteinase-14 (MMP14)
- Matrix metalloproteinase-7 (MMP7)
- Matrix metalloproteinase-9
- Neutrophil collagenase
- Stromelysin-1
9 IC50
- N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]methyl}-3,11,11-trioxo-8,1-dithia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-triene-5-carboxamide
- thiopyranothienopyrimidine, 1
- 72 kDa type IV collagenase
- Collagenase 3
- Interstitial collagenase
- Matrix metalloproteinase-12 (MMP12)
- Matrix metalloproteinase-14 (MMP14)
- Matrix metalloproteinase-7 (MMP7)
- Matrix metalloproteinase-9
- Neutrophil collagenase
- Stromelysin-1
25 IC50
- 13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),5-triene-5-carboxamide
- MMP Inhibitor, 7
- hexahydrobenzothienopyrimidine, 2
- Histone lysine demethylase PHF8
- Lysine-specific demethylase 2B
- Lysine-specific demethylase 3B
- Lysine-specific demethylase 4C
- Lysine-specific demethylase 5A
- Lysine-specific demethylase 5B
- Lysine-specific demethylase 5C
- Lysine-specific demethylase 6A
- Lysine-specific histone demethylase 1A
- US10022354, Example 29
- ADORA3
- Adenosine Receptors A2a (A2a)
- Adenosine receptor A1
- Met repressor
- Phenylethanolamine N-methyltransferase
- Phosphoehtnaolamine Methyltransferases 1 (PMT1)
- Protein-arginine N-methyltransferase 1
- Protein-beta-aspartate methyltransferase
- S-adenosylmethionine decarboxylase 1
9 ΔG°
- (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfanylium)butanoate
- AdoMet
- S-Adenosylmethionine
- S-adenosyl-L-[carboxy-14C]methionine
- [14COOH]AdoMet
- Anthrax Lethal Factor (LF)
- Botulinum Neurotoxin Type A
- Dual Specificity Protein Phosphatase 1
- Dual specificity protein phosphatase (VHR)
- Hematopoietic protein-tyrosine phosphatase (HEPTP)
- Leukocyte common antigen
- Low molecular weight phosphotyrosine protein phosphatase
- Protein-tyrosine phosphatase 1B
- phosphatase Cdc25
10 IC50
- 2-[(5Z)-5-[(3-{4-[(4-chlorophenyl)methoxy]phenyl}-1-phenyl-1H-pyrazol-4-yl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethane-1-sulfonic acid
- cid_4601225
- rhodanine derivative, 38
- 1,3-beta-glucan synthase component GLS2
- Cytoplasmic tyrosine-protein kinase BMX
- Epidermal growth factor receptor
- Receptor protein-tyrosine kinase erbB-4
- Receptor tyrosine-protein kinase erbB-2
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase TEC
- 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
- US10413562, Compound A250
- US9580449, Example A250
- US9580449, Example A39
- 1,3-beta-glucan synthase component GLS2
- CaM kinase II alpha/beta
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Calcium/calmodulin-dependent protein kinase type II subunit gamma
- Cytochrome P450 1A
- Cytochrome P450 2C19
- Cytochrome P450 2C9
- Cytochrome P450 2D6
- Cytochrome P450 3A
- (S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide
- US10100058, Example 141
- β-Carbonic anhydrase 2 (CA 2)
- Alpha carbonic anhydrase
- Carbonic Anhydrase (mtCA 1)
- Carbonic Anhydrase (mtCA 3)
- Carbonic Anhydrase 2 (Can2)
- Carbonic anhydrase
- Carbonic anhydrase 1
- Carbonic anhydrase 2
- beta-Carbonic Anhydrase
17 Ki
- CHEMBL451332
- sulfonamide, 3
- 5-hydroxytryptamine receptor 1A
- 5-hydroxytryptamine receptor 2A
- HTR6
- Norepinephrine Monoamine transporters
- Serotonin (5-HT) receptor
- Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
- Sodium-dependent dopamine transporter
- Sodium-dependent serotonin transporter
- Sphingosine 1-phosphate receptor 3
- 2-(1H-indol-3-yl)-N-methyl-ethanamine
- 2-(1H-indol-3-yl)-N-methylethanamine
- 2-(1H-indol-3-yl)ethyl-methyl-amine
- MLS000069493
- N-OMEGA-METHYLTRYPTAMINE
- N-methyltryptamine
- SMR000059062
- cid_6088
- 5-hydroxytryptamine receptor 1A
- Estradiol receptor beta (ERβ)
- Estrogen receptor
- Sphingosine 1-phosphate receptor 1
- Sphingosine 1-phosphate receptor 2
- Sphingosine 1-phosphate receptor 3
- dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
- lens epithelium-derived growth factor p75
- streptokinase A precursor
- MLS000049147
- N-(2-furanylmethyl)-7-hydroxy-2-oxo-1-benzopyran-3-carboxamide
- N-(2-furfuryl)-7-hydroxy-2-keto-chromene-3-carboxamide
- N-(2-furylmethyl)-7-hydroxy-2-oxo-2H-chromene-3-carboxamide
- N-(furan-2-ylmethyl)-7-hydroxy-2-oxochromene-3-carboxamide
- N-(furan-2-ylmethyl)-7-oxidanyl-2-oxidanylidene-chromene-3-carboxamide
- SMR000074483
- cid_5398663
- Epidermal growth factor receptor
- Fibroblast growth factor receptor 1
- Myelin transcription factor 1
- PDGFR-beta/Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor beta
- Proto-oncogene tyrosine-protein kinase Src
- Serine/threonine-protein kinase WEE1
- Tyrosine- and threonine-specific cdc2-inhibitory kinase
- Wee1-like protein kinase 2
- 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv.
- 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, Dihydrochloride
- 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
- CHEMBL49120
- PD166285
- PKC alpha and beta-2
- Protein kinase C (PKC)
- Protein kinase C alpha type
- Protein kinase C delta type
- Protein kinase C, epsilon
- Protein kinase C, eta
- Protein kinase C, gamma
- cAMP-Dependent Protein Kinase (PKA)
- cAMP-dependent protein kinase (PKA)
18 IC50
- 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzene)amido]cycloheptyl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid
- Balanol analog 2
- CHEMBL304549
- PKC alpha and beta-2
- Protein kinase C (PKC)
- Protein kinase C alpha type
- Protein kinase C delta type
- Protein kinase C, epsilon
- Protein kinase C, eta
- Protein kinase C, gamma
- cAMP-Dependent Protein Kinase (PKA)
- cAMP-dependent protein kinase (PKA)
18 IC50
- 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]piperidin-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid
- Balanol analog 3
- CHEMBL67442
- PKC alpha and beta-2
- Protein kinase C (PKC)
- Protein kinase C alpha type
- Protein kinase C delta type
- Protein kinase C, epsilon
- Protein kinase C, eta
- Protein kinase C, gamma
- cAMP-Dependent Protein Kinase (PKA)
- cAMP-dependent protein kinase (PKA)
57 IC50
- 2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid
- Balanol analog 4
- CHEMBL59828
- PKC alpha and beta-2
- Protein kinase C (PKC)
- Protein kinase C alpha type
- Protein kinase C delta type
- Protein kinase C, epsilon
- Protein kinase C, eta
- Protein kinase C, gamma
- cAMP-Dependent Protein Kinase (PKA)
- cAMP-dependent protein kinase (PKA)
61 IC50
- 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid
- Balanol analog 5
- CHEMBL52529
- Aurora kinase A/Targeting protein for Xklp2
- CDK2/Cyclin A/Cyclin A1
- CDK4/Cyclin D3
- CDK6/CycD3
- Cyclin-Dependent Kinase 2 (CDK2)
- Dual specificity protein kinase TTK
- Serine/threonine-protein kinase PLK1
- Serine/threonine-protein kinase PLK2
- Serine/threonine-protein kinase PLK3
14 IC50
- pyrazolo[4,3-h]quinazoline-3-carboxamide, 1
- PKC alpha and beta-2
- Protein kinase C (PKC)
- Protein kinase C alpha type
- Protein kinase C delta type
- Protein kinase C, epsilon
- Protein kinase C, eta
- Protein kinase C, gamma
- cAMP-Dependent Protein Kinase (PKA)
- cAMP-dependent protein kinase (PKA)
19 IC50
- 2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]bicyclo[2.2.1]heptan-2-yl}oxy)carbonyl]phenyl}carbonyl)-3-hydroxybenzoic acid
- Balanol analog 20
- Balanol analog 21