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Report error Found 970 of affinity data for UniProtKB/TrEMBL: P48147
TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135637(1-{(S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-car...)
Affinity DataKi:  0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50431227(CHEMBL2333024)
Affinity DataKi:  0.730nMAssay Description:Competitive inhibition of human PREP using Suc-GP-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  0.75nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataKi:  0.970nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  1nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POP using Z-Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200728((R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-ylboron...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200726((R)-1-(2-(cyclopentanecarboxamido)acetyl)pyrrolidi...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200721((R)-1-(2-(cyclohexanecarboxamido)acetyl)pyrrolidin...)
Affinity DataKi:  2.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200723((R)-1-(2-(1-oxoisoindolin-2-yl)acetyl)pyrrolidin-2...)
Affinity DataKi:  2.80nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50508977(CHEMBL4451993)
Affinity DataKi:  3.5nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:Inhibition of human prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50508977(CHEMBL4451993)
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of prolyl oligopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200720((R)-1-(2-(2,6-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  4.40nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200732((R)-1-(2-isobutyramidoacetyl)pyrrolidin-2-ylboroni...)
Affinity DataKi:  4.5nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50504804(CHEMBL4559324)
Affinity DataKi:  6nMAssay Description:Inhibition of recombinant human N-terminal His-tagged POP (2 to 710 residues) expressed in SF21 cells using Z-Gly-Pro-AMC as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50374364(CHEMBL273161)
Affinity DataKi:  6nMAssay Description:Inhibition of human prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200725((R)-1-(2-(N-methylbenzamido)acetyl)pyrrolidin-2-yl...)
Affinity DataKi:  7.40nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135636((S)-2-[(S)-2-(5-Cyano-isoxazole-3-carbonyl)-pyrrol...)
Affinity DataKi:  7.5nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50504801(CHEMBL4576969)
Affinity DataKi:  9nMAssay Description:Inhibition of recombinant human N-terminal His-tagged POP (2 to 710 residues) expressed in SF21 cells using Z-Gly-Pro-AMC as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50180664(CHEMBL3818013)
Affinity DataKi:  10nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200733((R)-1-(2-(N-methylisobutyramido)acetyl)pyrrolidin-...)
Affinity DataKi:  13nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:Inhibition of human prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; Moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50374289(CHEMBL269822)
Affinity DataKi:  16nMAssay Description:Inhibition of human prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  16nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  19nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50508977(CHEMBL4451993)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50508979(CHEMBL4558566)
Affinity DataKi:  22nMAssay Description:Inhibition of recombinant human POP pre-incubated for 2 hrs before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProlyl endopeptidase(Human)
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50393843(CHEMBL2159748)
Affinity DataKi:  23nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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