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Data for Coronaviruses: COVID-19, MERS & SARS

PMIDDataArticle TitleCitationOrganizationFiles Download
32935104 12 Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19.BDB bioRxiv (2020) Pfizer Inc. 2D 3D
32803196 48 Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening.BDB bioRxiv (2020) National Institutes of Health 2D 3D
32747425 43 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.BDB Sci Transl Med 12: (2020) Wichita State University 2D 3D
32428392 7 Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.BDB ACS Infect Dis 6: 2099-2109 (2020) University of Georgia 2D 3D
32321856 4 Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.BDB Science 368: 1331-1335 (2020) Shanghai Institute of Materia Medica 2D 3D
32272481 9 Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors BDB Nature 582: 289-293 (2020) ShanghaiTech University 2D 3D
32198291 3 Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved ?-ketoamide inhibitors.BDB Science 368: 409-412 (2020) University of Lubeck 2D 3D
29544147 36 Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.EBI Eur J Med Chem 150: 334-346 (2018) Wichita State University 2D 3D
27240464 24 Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.EBI Bioorg Med Chem 24: 3035-3042 (2016) Academia Sinica 2D 3D
25746232 16 Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.BDB ACS Chem Biol 10: 1456-65 (2015) University of Illinois at Chicago 2D 3D
24332657 35 Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.EBI Bioorg Med Chem 22: 167-77 (2014) University of Illinois at Chicago 2D 3D
24316352 27 Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.EBI Bioorg Med Chem 22: 292-302 (2014) Tianjin University of Science and Technology 2D 3D
24125888 2 Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.EBI Bioorg Med Chem Lett 23: 6317-20 (2013) Kansas State University 2D 3D
23647823 27 Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.EBI Bioorg Med Chem 21: 3730-7 (2013) Korea Research Institute of Bioscience and Biotechnology 2D 3D
23323951 10 Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.BDB J Enzyme Inhib Med Chem 29: 59-63 (2014) Gyeongsang National University 2D 3D
23202846 4 Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.EBI Eur J Med Chem 59: 1-6 (2013) The Chinese University of Hong Kong 2D 3D
22884354 36 Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.EBI Bioorg Med Chem 20: 5928-35 (2012) Korea Research Institute of Bioscience and Biotechnology 2D 3D
21470860 9 Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation.EBI Bioorg Med Chem Lett 21: 3088-91 (2011) Chonnam National University 2D 3D
20947359 18 Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors.EBI Bioorg Med Chem 18: 7849-54 (2010) Academia Sinica 2D 3D
20934345 20 Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.EBI Bioorg Med Chem 18: 7940-7 (2010) Korea Research Institute of Bioscience and Biotechnology 2D 3D
20167482 10 SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.EBI Bioorg Med Chem Lett 20: 1873-6 (2010) Korea Research Institute of Bioscience and Biotechnology 2D 3D
19645480 24 Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease.BDB J Med Chem 52: 5228-40 (2009) Purdue University 2D 3D
19625187 22 Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.EBI Bioorg Med Chem Lett 19: 4538-41 (2009) Konkuk University 2D 3D
19540764 1 Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.EBI Bioorg Med Chem 17: 5139-45 (2009) National Human Genome Research Institute 2D 3D
19362479 15 New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.EBI Bioorg Med Chem Lett 19: 2722-7 (2009) Kyoto Pharmaceutical University 2D 3D
19233643 16 Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.EBI Bioorg Med Chem Lett 19: 1636-8 (2009) Konkuk University 2D 3D
19144641 8 Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.BDB J Biol Chem 284: 7646-55 (2009) National Yang-Ming University 2D 3D
18343121 2 Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits.BDB Bioorg Med Chem 16: 4138-49 (2008) University of Mississippi 2D 3D
17855091 7 Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.EBI Bioorg Med Chem Lett 17: 5876-80 (2007) Purdue University 2D 3D
17709464 8 Novel small-molecule inhibitors of transmissible gastroenteritis virus.EBI Antimicrob Agents Chemother 51: 3924-31 (2007) National Health Research Institute 2D 3D
17381079 8 Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.EBI J Med Chem 50: 1850-64 (2007) University of Alberta 2D 3D
16913704 21 Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.BDB J Med Chem 49: 5154-61 (2006) National Defense Medical Center 2D 3D
16884309 5 Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.BDB J Med Chem 49: 4971-80 (2006) TaiGen Biotechnology Co. 2D 3D
16759091 28 Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.BDB J Med Chem 49: 3485-95 (2006) National Tsing Hua University 2D 3D
16759084 12 Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.EBI J Med Chem 49: 3440-3 (2006) Peking University 2D 3D
16638531 16 Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.BDB Chem Biol 13: 261-8 (2006) Academia Sinica 2D 3D
16250632 2 Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.EBI J Med Chem 48: 6767-71 (2005) Purdue University 2D 3D
15994085 21 Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.BDB Bioorg Med Chem 13: 5240-52 (2005) National Taiwan University 2D 3D
15974598 9 Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease.BDB J Med Chem 48: 4469-73 (2005) National Taiwan University 2D 3D
15950190 10 Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease.BDB Biochem Biophys Res Commun 333: 194-9 (2005) National Taiwan University 2D 3D
15896959 14 Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.EBI Bioorg Med Chem Lett 15: 3058-62 (2005) Development Center for Biotechnology 2D 3D
  4 Discovery of potent inhibitors of PLproCoV2 by screening a library of selenium-containing compoundsBDB bioRxiv 1-12 (2020) University ofAmsterdam 2D 3D
WO2005113580A1101 Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesisBDB WIPO (2005) Pfizer Inc.
US9975885182 Broad-spectrum non-covalent coronavirus protease inhibitorsBDB US Patent US9975885 (2018) PURDUE RESEARCH FOUNDATION

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