BDBM50089194 (R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide::(R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide::ACTINONIN::CHEMBL308333::N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide::N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide
SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
InChI Key InChIKey=XJLATMLVMSFZBN-VYDXJSESSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50089194
Affinity DataKi: 0.300nMAssay Description:Binding affinity of the compound towards Peptide deformylaseMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by ChEMBL
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by ChEMBL
Fraunhofer Institute For Cell Therapy And Immunology Izi
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+5nMAssay Description:Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 minMore data for this Ligand-Target Pair
Affinity DataKi: 3.90E+5nMAssay Description:Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 minMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human mitochondrial PDFMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibitory concentration required against peptide deformylase (PDF)More data for this Ligand-Target Pair
TargetPeptide deformylase(Staphylococcus aureus)
Korea Research Institute Of Bioscience And Biotechnology
Curated by ChEMBL
Korea Research Institute Of Bioscience And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Staphylococcus aureus peptide deformylase using N-formylmethionine-alanine-serine as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetPeptide deformylase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureusMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 830nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
Affinity DataIC50: >2.59E+5nMAssay Description:Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human PDF using N-formylated peptide as substrate in presence of NAD+ by formate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human PDF expressed in Escherichia coli BL21 pLysS using formyl-Met-Ala-His-Ala peptide as substrate measured after 1 hr by fluorescami...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of Escherichia coli peptide deformylase using fMAHA as substrate after 1 hr by FLUO assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human peptide deformylase after 1 hr by fluorescence polarization based competition assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
British Biotech Pharmaceuticals
Curated by ChEMBL
British Biotech Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was tested for its inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antibacterial activity of the compound against E. coli Peptide deformylase. NiMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
British Biotech Pharmaceuticals
Curated by ChEMBL
British Biotech Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:The compound was evaluated in vitro for the inhibition of Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
TargetPeptide deformylase 1A, chloroplastic/mitochondrial(Arabidopsis thaliana)
Centre National De La Recherche Scientifique
Curated by ChEMBL
Centre National De La Recherche Scientifique
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of Arabidopsis thaliana mitochondrial PDF1AMore data for this Ligand-Target Pair