BDBM15296 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile::6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile::CHEMBL189::Milrinone::Primacor::US9242982, Milrinone::US9249139, Milrinone

SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N

InChI Key InChIKey=PZRHRDRVRGEVNW-UHFFFAOYSA-N

Data  7 KI  52 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 15296   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi:  150nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi:  4.67E+3nMAssay Description:Inhibition of Cavia porcellus (guinea pig) PDE3 isolated from heart using [3H]cAMP as substrate by two-step methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University Of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University Of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of full length human Mps1 using fluorescence-labeled H236 peptide as substrate after 60 to 90 mins in presence of ATP by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of full length N-terminal His-tagged Aurora A (unknown origin) using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.20E+5nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  740nMAssay Description:Inhibitory activity against cGMP-phosphodiesterase from porcine aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.20E+5nMAssay Description:Inhibition of cAMP-phosphodiesterase PDE 2 from guinea pig, range 140-300More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed as cAMP hydrolysis after 60 mins by fluorescence polarization assay using fluorescein-tagged cAMP as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of thrombin-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human platelet phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant PDE3A assessed as cGMP hydrolysis after 60 mins by fluorescence polarization assay using tetramethylrhodamine-tagged ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 10.4-16.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of phosphodiesterase 2 (PDE2) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50: >1.00E+5nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Sus scrofa)
Eisai

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  843nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 0.581-1.23More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory concentration against cGMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.40E+5nMAssay Description:Inhibitory concentration against cGMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory concentration against cGMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibitory concentration against cAMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of cAMP PDE I enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.40E+5nMAssay Description:Inhibition cGMP PDE I enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of cAMP PDE III enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.20E+5nMAssay Description:Inhibition of cAMP PDE II enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of canine Phosphodiesterase III (PDE 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.98E+5nMAssay Description:Inhibition of canine PDE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of phosphodiesterase 1 (PDE I)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  860nMAssay Description:In vivo inhibition of cyclic AMP phosphodiesterase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.40E+5nMAssay Description:Inhibition of cGMP phosphodiesterase PDE 1 from guinea pig, range 170-510More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of cAMP-phosphodiesterase PDE 3 from guinea pig, range 1.9-3.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of cAMP-phosphodiesterase PDE 1 from guinea pig, range 190-430More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of cGMP phosphodiesterase PDE 2 from guinea pig, range 120-290More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of canine cardiac cAMP phosphodiesterase (cAMP-PDE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  1.20E+4nMAssay Description:Cardiotonic effect by inhibition of cAMP phosphodiesterase (PDE III)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  360nMAssay Description:Inhibition of cAMP Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  860nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of fraction III of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  360nMAssay Description:In vitro inhibitory activity against cAMP phosphodiesterase III in dog aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  730nMAssay Description:Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  730nMAssay Description:Inhibition of guinea pig ventricular Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human platelet PDE3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 59 total ) | Next | Last >>