BDBM50015214 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine::6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine::CHEMBL7568::N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine (Mepacrine)::N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine ; (mepacrine)::N-(4-Hydroxy-phenyl)-acetamide::cid_237::quinacrine
SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
InChI Key InChIKey=GPKJTRJOBQGKQK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50015214
Affinity DataKi: 6.70E+3nMAssay Description:Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
TargetTrypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plotsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.16E+6nMAssay Description:Inhibition of snake venom phospholipase A2 assessed as oxygen consumption for 3 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rabbit aldehyde oxidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of Equine serum BChE using butyrylthiocoline iodide as a substrate after 20 mins by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataKd: 264nMpH: 7.4Assay Description:Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Tested for its inhibitory activity against Phospholipase A2 (PLA2)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Tested for its inhibitory activity against 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of rat basophilic leukemia cell 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against polymorphonuclear cell phospholipase-A2 in ratMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+8nMAssay Description:In vitro inhibition of rat secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
Affinity DataIC50: 7.60E+7nMAssay Description:In vitro inhibition of human recombinant secretory Phospholipase A2 (group II).More data for this Ligand-Target Pair
TargetMajor prion protein(Homo sapiens (Human))
Institut F£R Molekularbiologie Und Biophysik
Curated by ChEMBL
Institut F£R Molekularbiologie Und Biophysik
Curated by ChEMBL
Affinity DataEC50: 300nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.26E+4nMAssay Description:Tested for its inhibitory activity against PGS (prostaglandin synthetase).More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
Affinity DataEC50: 1.44E+4nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.15E+6nMAssay Description:Inhibition of Naja Naja PLA2More data for this Ligand-Target Pair
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Kyoto Institute Of Technology
Curated by ChEMBL
Kyoto Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 2.92E+5nMAssay Description:Inhibition of Tween 20-induced beta-hematin formation by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of ovine seminal vesicle prostaglandin synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of human placental Monoamine oxidase A (competitive inhibition was observed)More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of cGAS (unknown origin) incubated for 1 hr by Typhoon imaging system analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of cGAS in human THP-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL21 (DE3) using TS2 and NADPH as...More data for this Ligand-Target Pair
TargetMajor prion protein(Mus musculus)
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)
Curated by ChEMBL
Scuola Internazionale Superiore Di Studi Avanzati (Sissa)
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysisMore data for this Ligand-Target Pair
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
University Of Cape Town
Curated by ChEMBL
University Of Cape Town
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory concentration of the compound against human Glutathione reductase was determinedMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Alma Mater Studiorum-Bologna University
Curated by ChEMBL
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibitory concentration of the compound against trypanothione reductase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation countingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay