BDBM50384998 CVD-0019905::XANTHOHUMOL

SMILES [#6]-[#8]-c1cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c(-[#8])c1-[#6](=O)\[#6]=[#6]\c1ccc(-[#8])cc1

InChI Key InChIKey=ORXQGKIUCDPEAJ-YRNVUSSQSA-N

Data  7 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50384998   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human PKC alpha assessed as inhibition of [33P] incorporation into substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 3(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLymphocyte antigen 96(Homo sapiens (Human))
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataKd:  4.60E+5nMAssay Description:Binding affinity to recombinant human MD2 (17 to 160 residues) expressed in Escherichia coli BL21(DE3) cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli MV1190 cells preincubated for 10 mins followed by addition of arachidonic acid as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50:  9.95E+4nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human PDK1 assessed as inhibition of [33P] incorporation into substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human PKC theta assessed as inhibition of [33P] incorporation into substrate after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataKd:  1.20E+4nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM50384998(CVD-0019905 | XANTHOHUMOL)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes preincubated for 10 mins followed by addition of arachidonic acid as substrate measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed