BDBM50038879 (S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester::CHEMBL79993::JTP-4819::Z-PRO-PROLINAL

SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1

InChI Key InChIKey=ORZXYSPOAVJYRU-HOTGVXAUSA-N

Data  8 KI  7 IC50

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50038879   

TargetProlyl endopeptidase(Bos taurus)
McGill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Bos taurus)
McGill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrateMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Mus musculus)
McGill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
McGill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of prolyl oligopeptidaseMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  51.6nMAssay Description:Inhibition of Flavobacterium meningosepticum PEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
McGill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  1.27nMAssay Description:Inhibition of Flavobacterium meningosepticum propyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  0.330nMAssay Description:In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressedMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  0.330nMpH: 7.0Assay Description:In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...More data for this Ligand-Target Pair