BDBM101090 US10189794, Compound I-246::US10618902, Compound I-246::US10774052, Compound I-246::US9695132, I-246
SMILES CN1C(=O)N(Cc2cnc(NC3COCC3NC(=O)C=C)nc12)c1cc(ccc1Cl)C(=O)Nc1cccc(c1)C(C)(C)C#N
InChI Key InChIKey=FSBMVFGCNYKLOZ-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 101090
Affinity DataIC50: 251nMpH: 7.5Assay Description:Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:For MDA-MB-453 cells signaling, cells were grown in 96-well poly-D-lysine plates (BD Bioscience, San Jose, Calif.) to 90% confluence, and were then i...More data for this Ligand-Target Pair
Affinity DataIC50: 2.75E+3nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 7, was prepared as described below...More data for this Ligand-Target Pair