BDBM103290 US8546404, 412

SMILES COC[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1

InChI Key InChIKey=DPZYBMURJGUYOT-DIPNUNPCSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 103290   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM103290(US8546404, 412)Copy SMILESCopy InChI

Affinity DataIC50:  41nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent

LigandBDBM103290(US8546404, 412)Copy SMILESCopy InChI

Affinity DataIC50:  38.5nMAssay Description:Activated ERK2 activity was determined in the IMAP assay format.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI