BDBM10348 5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione::5-{[(2S)-2-[(pyridin-3-yloxy)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione::IST-1::Pyridine Analogue 20

SMILES O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCC[C@H]1COc1cccnc1

InChI Key InChIKey=ZQDAIIUFJKGWON-LBPRGKRZSA-N

Data  1 KI  6 IC50  1 EC50  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 10348   

TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataKi:  16.1nMAssay Description:Enzyme activities with or without inhibitors were measured using a fluorescence assay. The formation of the cleavage product AFC was monitored for 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50:  215nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Washington University

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50:  58.9nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataEC50:  1.83E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50:  58.3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 10348   

CellCaspase-3(Homo sapiens (Human))
Wyeth Research

SyringePNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
ITC DataΔG°: -10.3kcal/mole −TΔS°: 1.74kcal/mole ΔH°: -12.0kcal/mole logk: 3.57E+7
pH: 7.2 T: 25.00°C 
In DepthDetails ArticlePubMed